Activity of plant flavonoids against antibiotic-resistant bacteria

Xu, Hong‐Xi; Lee, Song F.

doi:10.1002/1099-1573(200102)15:1<39::aid-ptr684>3.0.co;2-r

Cited by 228 publications

(134 citation statements)

References 17 publications

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“…Os produtos naturais são uma alternativa extremamente viável, uma vez que sempre foram importantes para o descobrimento de novas drogas, sendo fornecedoras de princípio ativo e por ser também uma alternativa mais econômica no controle de doenças para países em desenvolvimento, onde a maioria das drogas é importada (Xu;Lee, 2001). Segundo Cowan (1999), atualmente um quarto da metade de todos os fármacos comercializados são originários de plantas, porém nenhum destes é usado como antimicrobiano, a grande maioria é usada como suplementos vitamícos e dietéticos.…”

Section: Discussionunclassified

Atividade antimicrobiana do extrato de Anacardium occidentale Linn. em amostras multiresistentes de Staphylococcus aureus

Silva¹,

Souza²,

Higino³

et al. 2007

Rev. bras. farmacogn.

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RESUMO:Plantas medicinais com propriedades terapêuticas são de grande relevância em todo o mundo, principalmente em países em desenvolvimento. A planta Anacardium occidentale Linn. é largamente usada na medicina tradicional na nossa região, como antidiarréico, para amigdalite, bronquites, artrites, e antiifl amatório. No presente estudo avaliou-se a ação antimicrobiana do extrato hidroalcóolico da casca do caule do cajueiro frente a amostras de Staphylococcus aureus resistentes e sensíveis à meticilina, obtidas a partir de pacientes internados do Hospital Universitário/Universidade Federal da Paraíba. A atividade antimicrobiana foi determinada pelo método de difusão em meio sólido para a determinação da Concentração Inibitória Mínima do extrato, e foi observada no total de 30 amostras, pela presença ou não do halo de inibição. Todas as amostras ensaiadas mostraram-se sensíveis à ação do extrato do cajueiro, com diâmetros dos halos de inibição variando de 10 a 20 mm, demonstrando grande efi cácia do cajueiro. Assim, o uso desta planta na nossa região pode inferir uma alternativa terapêutica efi ciente e de baixo custo, contra infecções bacterianas causadas por Staphylococcus aureus.Unitermos: Anacardiaceae, Anacardium occidentale, Staphylococcus aureus, atividade antimicrobiana.ABSTRACT: "Antimicrobial activity of the hydroalcoholic extract of Anacardium occidentale Linn. against multi-drug resistant strains of Staphylococcus aureus". Medicinal plants with therapeutical properties are of great signifi cance in the whole world, especially in developing countries. Anacardium occidentale Linn. is a plant widely used in the traditional medicine in our region against diarrhea, tonsillitis, bronchitis, arthritis, and infl ammation. In this paper, the antimicrobial activity of the hydroalcoholic extract of the cashew tree stem was evaluated against samples of meticillin-resistant and meticillin-sensible Staphylococcus aureus, attained from patients interned at Hospital Universitário/Universidade Federal da Paraíba. The antimicrobial activity was determined by the diffusion method in solid milieu to determine the Minimum Inhibitory Concentration (MIC) of the extract, and it was observed in 30 samples the presence or not of inhibition zone. All the assayed samples proved to be sensible to the activity of the extract of the cashew tree, with inhibition zones diameter of 10 to 20 mm, displaying consequently great effectiveness of the extract of the cashew tree stem. Thus, the use of this plant in our region can infer a low cost and effi cient therapeutical alternative against bacterial infections caused by Staphylococcus aureus.

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Section: Discussionunclassified

Atividade antimicrobiana do extrato de Anacardium occidentale Linn. em amostras multiresistentes de Staphylococcus aureus

Silva¹,

Souza²,

Higino³

et al. 2007

Rev. bras. farmacogn.

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“…Flavonoids, which are chemically defined as benzo-γ-pyrone derivatives and consist of phenolic and pyran rings (Heim, Tagliaferro, & Bobilya, 2002), are in fact associated with potential bioactive properties (Heim et al, 2002;Ross & Kasum, 2002;FernandezPanchon, Villano, Troncoso, & Garcia-Parrilla, 2008). Their efficient use as natural colourings has been demonstrated a number of times (Bridle & Timberlake, 1997;Espin, Soler-Rivas, Wichers, & Garcia-Viguera, 2000), food antioxidants (Kranl et al, 2005;Capitani, Carvalho, Rivelli, Barros, & Castro, 2009), and antimicrobial agents (Xu & Lee, 2001;Cushnie & Lamb, 2005). In these terms, conventional and emerging technologies such as supercritical and subcritical, microwave-and ultrasound-assisted extraction can be used to develop a tailored-made process of extracting and purifying flavonoids from date seeds; however, more studies are needed to identify the most efficient, environmentally friendly and economically feasible method.…”

Section: Tac (Orac)mentioning

confidence: 99%

Determination of the antioxidant capacity, total phenolic and flavonoid contents of seeds from three commercial varieties of culinary dates

Mistrello¹,

Sirisena²,

Ghavami

et al. 2014

Int. J. Food Stud.

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Date seeds are a major waste product of the date industry that could offer potentially valuable material for the production of useful food ingredients. The aim of the present study was to investigate the seeds of three date varieties of the UK market (Deglet Nour, Khouat Allig, and Zahidi) for their proximate composition, total phenolic (TPC), total flavonoid (TFC) contents and total antioxidant capacity (TAC) with a view to their eventual industrial application. Carbohydrates were present in the highest concentrations varying between 74.13 and 76.54 g 100 g −1 of date seed powder (DSP) on dry weight (DW) basis, followed in descending order by fats (7.64-8.84 g 100 g −1 ) and proteins (4.35-5.51 g 100 g −1 ). Potassium was found in high amounts with values ranging between 280.55 and 293.13 mg 100 g −1 . The majority of the total phenolic content (2058-2984 mg GAE 100 g −1 ) was assumed to be composed of flavonoids (1271-1932 mg CAE 100 g −1 ). These families of dietary phenolics may be the major ones responsible for the high antioxidant capacity reported in date seeds, which varied from 12540 and 27699 µmol TE 100 g −1 . These results suggest that date seeds can be considered a potential raw material for natural, active ingredients for food applications as well as an unexplored source of novel nutraceuticals and dietary supplements.

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“…''Natural'' and ''traditional'' foods, processed without any added chemical preservative, are becoming more and more attractive [42]. When chemical preservatives are used, the low levels used to avoid health implications expose the food-makers to a risk of poor stability and microbial contamination of the final products, since several microorganisms (pathogens and spoilage agents) may acquire a resistance [47]. In particular, the emergence of pathogens, which are resistant to classical preservatives, has determined an urgent necessity for alternative antimicrobial agents.…”

Section: Introductionmentioning

confidence: 99%

Chemical Composition and Antibacterial Potential of Artemisia arborescens L. Essential Oil

et al. 2010

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This study was undertaken to characterize the essential oil (EO) of Artemisia arborescens growing wild in Sicily. EO, extracted by steam distillation, was examined for its chemical composition and for its capability to inhibit some food-borne pathogen bacteria. A total of 43 compounds (13 monoterpene hydrocarbons, 14 oxygenated monoterpenes, 10 sesquiterpene hydrocarbons, three oxygenated sesquiterpenes and less amount of other three compounds), which account 93.73% of the total oil, were identified by gas chromatography and gas chromatography-mass spectrometry. Oxygenated monoterpenes (57.32%) constituted the main fraction, with b-thujone as the main compound (45.04%), followed by the sesquiterpene hydrocarbon chamazulene (22.71%). Undiluted EO showed a large inhibition spectrum against strains of Listeria monocytogenes (34 out of 44), whilst it was ineffective against enterobacteria and salmonellas. The minimum inhibition concentration (MIC) was evaluated for the two most sensitive strains (L. monocytogenes 186 and 7BO) at two cellular concentrations (10 6 and 10 7 CFU ml -1 ). The lowest MIC (0.625 ll ml -1 , dilution of oil with acetone) was found for strain L. monocytogenes 186 at 10 6 CFU ml -1 .

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Activity of plant flavonoids against antibiotic-resistant bacteria

Cited by 228 publications

References 17 publications

Atividade antimicrobiana do extrato de Anacardium occidentale Linn. em amostras multiresistentes de Staphylococcus aureus

Atividade antimicrobiana do extrato de Anacardium occidentale Linn. em amostras multiresistentes de Staphylococcus aureus

Determination of the antioxidant capacity, total phenolic and flavonoid contents of seeds from three commercial varieties of culinary dates

Chemical Composition and Antibacterial Potential of Artemisia arborescens L. Essential Oil

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