Activity of Melaleuca alternifolia (tea tree) oil on Influenza virus A/PR/8: Study on the mechanism of action

Garozzo, A; Timpanaro, R.; Stivala, Aldo; Bisignano, Carlo; Castro, A.

doi:10.1016/j.antiviral.2010.11.010

Cited by 118 publications

(74 citation statements)

References 27 publications

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“…The exposure of the enveloped viruses such as HSV-1, HSV-2 and dengue viruses to the antiviral components prior to cell infection resulted in prevention of cell infection [3]. On the other hand, in a few studies, the plant antiviral ingredients showed to be effective against the intracellular steps of enveloped viruses such as HSV-1, bovine herpesvirus type 2, human immunodeficiency virus type 1, influenza A virus, influenza B virus, and human respiratory syncytial virus [11,12,16,19].…”

Section: Discussionmentioning

confidence: 99%

Antiviral activity of the oseltamivir and Melissa officinalis L. essential oil against avian influenza A virus (H9N2)

et al. 2016

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Lemon balm derivatives are going to acquire a novelty as natural and potent remedy for treatment of viral infections since the influenza viruses are developing resistance to the current antivirals widely. Oseltamivir, Melissa officinalis essential oil (MOEO) and their synergistic efficacy against avian influenza virus (AIV) subtype H9N2 were evaluated in vitro in MDCK cells at different time exposure by using TCID50, HA, Real Time PCR and HI assay. The results showed that MOEO could inhibit replication of AVI through the different virus replication phase (P B 0.05). Also the highest antiviral activity of MOEO was seen when AIV incubated with MOEO before cell infection. The TCID50/ml was reduced 1.3-2.1, 2.3-2.8, 3.7-4.5 log 10 than control group (5.6 log 10), HAU/50 ll was decreased 85-94, 71.4-94, 71.4-94 % and viral genome copy number/ll was brought down 68-95, 90-100, 89.6-99.9 % at pre-infection, post-infection and simultaneous stage, respectively. Hemagglutination inhibition result showed the MOEO was not able to inhibit agglutination of the chicken red blood cell (cRBC). Replication of the AVI was suppressed by the different concentration of oseltamivir completely or near 100 %. Also oseltamivir showed a synergistic activity with MOEO especially when oseltamivir concentration reduced under 0.005 mg/ml. The chemical composition was examined by GC-MS analysis and Its main constituents were identified as monoterpenaldehydes citral a, citral b. In conclusion, the findings of the study showed that lemon balm essential oil could inhibit influenza virus replication through different replication cycle steps especially throughout the direct interaction with the virus particles.

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Section: Discussionmentioning

confidence: 99%

Antiviral activity of the oseltamivir and Melissa officinalis L. essential oil against avian influenza A virus (H9N2)

et al. 2016

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“…The antiviral activity of tea tree oil is attributed to its main compounds: terpinen-4-ol, terpineol and terpinolene [45]. Although single selected monoterpenes showed high antiviral activity (α-pinen and α-terpinen), the mixture of them in natural tea tree essential oils was ten-fold more effective [45]. Unlike the antibacterial effect, the antiviral activity of monoterpenes does not equally contribute to the antiviral effect of a given essential oil.…”

Section: Composition and Mechanism Of Antimicrobial Action Of Essentimentioning

confidence: 99%

“…A specific inhibition of CMV early gene expression was observed after the treatment with Euonymus sesquiterpenes [39] or inhibited glucosylation of viral proteins as an effect of monoterpenes activity [38]. The antiviral activity of tea tree oil is attributed to its main compounds: terpinen-4-ol, terpineol and terpinolene [45]. Although single selected monoterpenes showed high antiviral activity (α-pinen and α-terpinen), the mixture of them in natural tea tree essential oils was ten-fold more effective [45].…”

Section: Composition and Mechanism Of Antimicrobial Action Of Essentimentioning

confidence: 99%

Application of essential oils as natural cosmetic preservatives

Dreger

Wielgus

2013

Herba Polonica

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S u m m a r yNowadays, safety of chemical preservatives has been questioned by a big number of consumers. Traditionally used preservatives often cause skin irritation and lead to allergenic reactions. Growing demands for more natural and preservative-free cosmetics promoted an idea of the replacement of synthetic preservatives with essential oils (EOs) of antimicrobial properties. The antimicrobial effect of essential oil depends on content, concentration and interactions between the main active compounds. Effective preservatives should be characterized by a broad spectrum of antimicrobial activity at a minimum concentration. Formulations containing both types of preservatives: essential oil and a synthetic one have been tested and proposed as a compromise that allows for reducing concentration of both components due to their synergistic activity. Although most essential oils are regarded as safe, some of them may cause risk of contact allergy or phototoxic reaction. A well balanced risk-benefit assessment of essential oils is one of the great challenges for scientists or health policy authorities. This paper presents current state of knowledge on essential oils focused on their antimicrobial properties, the assessment of their efficacy and safety as cosmetic preservatives.

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“…One possible approach is to determine whether bioactive compounds from natural products and traditional medicinal plants, which have strong bactericidal activity against MRSA, either show synergistic interaction with antibiotics or enhance the susceptibility level of resistant S. aureus to methicillin (Aiyegoro et al 2011). Thus, such peptides represent promising foundations for developing a new generation of antimicrobial agents (Wang 2010).The EOs usually possess antimicrobial activity not only against bacteria, but also against fungi (Tyagi & Malik 2010), protozoans (Monzote et al 2007) and viruses (Garozzo et al 2011) which is especially important in mixed infections. Furthermore, EOs also have antiinflammatory (Miguel 2010), immune modulatory (Sadlon & Lamson 2010), antioxidant (Miguel 2010;Serrano et al 2011) and regenerative activities, which make them promising agents in the treatment of different infections.…”

Section: Methicillin-resistant S Aureusmentioning

confidence: 99%

Inhibition of methicillin-resistant Staphylococcus aureus (MRSA) by antimicrobial peptides (AMPs) and plant essential oils

Zouhir

Jridi

Nefzi

et al. 2016

Pharmaceutical Biology

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Activity of Melaleuca alternifolia (tea tree) oil on Influenza virus A/PR/8: Study on the mechanism of action

Cited by 118 publications

References 27 publications

Antiviral activity of the oseltamivir and Melissa officinalis L. essential oil against avian influenza A virus (H9N2)

Antiviral activity of the oseltamivir and Melissa officinalis L. essential oil against avian influenza A virus (H9N2)

Application of essential oils as natural cosmetic preservatives

Inhibition of methicillin-resistant Staphylococcus aureus (MRSA) by antimicrobial peptides (AMPs) and plant essential oils

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