2007
DOI: 10.1016/j.brainres.2007.06.017
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Activity of mannitol and hypertonic saline therapy on the oxidant and antioxidant system during the acute term after traumatic brain injury in the rats

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Cited by 34 publications
(24 citation statements)
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“…Cordycepin and cordycepic acid (D-mannitol) have been used generally as a marker for quality control in the medicinal value of Cordyceps (Li et al, 2006;Das et al, 2010;Xiao et al, 2010). Yilmaz et al (2007) pointed out that cordycepic acid could be used to decrease intracranial pressure in rats, increase the content of peroxidase and glutathione peroxidase in rat blood and reduce the formation of malondialdehyde, a marker for oxidative stress, thereby reducing cell damage. In a normal functional state, a dynamic balance is achieved Wang et al: Cordyceps Militaris Waster Medium as Additive through the interactions between an organism's antioxidant system and the formation of free radicals or active oxygen products.…”
Section: Discussionmentioning
confidence: 99%
“…Cordycepin and cordycepic acid (D-mannitol) have been used generally as a marker for quality control in the medicinal value of Cordyceps (Li et al, 2006;Das et al, 2010;Xiao et al, 2010). Yilmaz et al (2007) pointed out that cordycepic acid could be used to decrease intracranial pressure in rats, increase the content of peroxidase and glutathione peroxidase in rat blood and reduce the formation of malondialdehyde, a marker for oxidative stress, thereby reducing cell damage. In a normal functional state, a dynamic balance is achieved Wang et al: Cordyceps Militaris Waster Medium as Additive through the interactions between an organism's antioxidant system and the formation of free radicals or active oxygen products.…”
Section: Discussionmentioning
confidence: 99%
“…The 50% inhibitory concentration (IC 50 ) value of mannitol is about 9.6 mM. The antioxidant experiments testify that complex 1 (IC 50 ¼ 4 mM) and complex 2 (IC 50 ¼ 5 mM) represent very excellent antioxidant (OH ) activities which are much better than that of standard antioxidants like mannitol and Vitamin C [44]. Fig.…”
Section: Viscosity Measurementmentioning
confidence: 98%
“…Kogan et al [11] demonstrated antioxidant properties of CMG in the lipid peroxidation model induced by • OH radicals produced by Fenton's reagent and microwave irradiation [50]. Its radical scavenging activity was compared to that of water-soluble d-mannitol, frequently considered as a reference for carbohydrate-type antioxidants [71]. For (1→3)-␤-d-glucan derivative the scavenging activity was much stronger than that for d-mannitol [50,71].…”
Section: Discussionmentioning
confidence: 99%
“…Its radical scavenging activity was compared to that of water-soluble d-mannitol, frequently considered as a reference for carbohydrate-type antioxidants [71]. For (1→3)-␤-d-glucan derivative the scavenging activity was much stronger than that for d-mannitol [50,71]. These findings suggest that the increased antioxidant activity of polysaccharides in comparison with monosaccharides is due to the fact that polysaccharides contain multiple anomeric hydrogen atoms, which are primarily abstracted by the active free radicals, while monosaccharides possess only one such anomeric hydrogen [50].…”
Section: Discussionmentioning
confidence: 99%