Activity of Human Hippocampal Formation and Amygdala Neurons During Sleep

Ravagnati, L.; Halgren, Eric; Babb, Thomas L.; Crandall, Paul H.

doi:10.1093/sleep/2.2.161

Cited by 28 publications

(12 citation statements)

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“…However, pyramidal cell discharges decreased during the periods when rodents show robust RSA associated with REM sleep and ambulatory behavior (Suzuki and Smith, 1987;Chrobak and Buzsaki, 1996). Similar sleep-related changes in firing rate were found in our human hippocampal single neuron recordings, as well as in two previous studies, one in the rodent (Suzuki and Smith, 1985a) and the other in human recordings of multi-unit hippocampal activity (Ravagnati et al, 1979). In contrast, human functional neuroimaging studies during sleep have revealed a deactivation of the hippocampal formation during SWS (Maquet et al, 1997) and activation during REM sleep (Nofzinger et al, 1997).…”

Section: Firing Ratesupporting

confidence: 88%

Single neuron burst firing in the human hippocampus during sleep

et al. 2002

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Although there are numerous non-primate studies of the single neuron correlates of sleep-related hippocampal EEG patterns, very limited hippocampal neuronal data are available for correlation with human sleep. We recorded human hippocampal single neuron activity in subjects implanted with depth electrodes required for medical diagnosis and quantitatively evaluated discharge activity from each neuron during episodes of wakefulness (Aw), combined stage 3 and 4 slow-wave sleep (SWS), and rapid eye movement (REM) sleep. The mean firing rate of the population of single neurons was significantly higher during SWS and Aw compared with REM sleep (p = 0.002; p < 0.0001). In addition, burst firing was significantly greater during SWS compared with Aw (p = 0.001) and REM sleep (p < 0.0001). The synchronized state of SWS and associated high-frequency burst discharge found in human hippocampus may subserve functions similar to those reported in non-primate hippocampus that require burst firing to induce synaptic modifications in hippocampal circuitry and in hippocampal projections to neocortical targets that participate in memory consolidation.

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Section: Firing Ratesupporting

confidence: 88%

Single neuron burst firing in the human hippocampus during sleep

et al. 2002

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“…During dream states there is a specific pattern of neuronal activity in the hippocampus and amygdala (Ravagnati, Halgren, Babb, and Crandall, 1977), suggesting again that limbic structures are involved in experi ential mental phenomena.…”

Section: Discussionmentioning

confidence: 97%

A neurobiological model for near-death experiences

Saavedra-Aguilar

Gómez-Jeria

1989

J Near-Death Stud

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ABSTRACT:The authors present a neurobiological model for near-death experiences (NDEs) in an attempt to correlate the biological and psychological domains. This model is based on temporal lobe dysfunction, hypoxialischemia, stress, and neuropeptide/neurotransmitter imbalance. They describe and dis cuss the fundamental contribution of the language system in the construction of verbal reports of NDEs. This model could be seen as a complement to other explanatory domains.The phenomenology of near-death experiences (NDEs) has been de scribed by several authors (Greyson, 1981(Greyson, , 1983a(Greyson, , 1983b(Greyson, , 1985

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“…This may be due to their method of analyzing electrical activity or because the activity of the lateral, as opposed to the basal, amygdaloid nucleus does not reveal changes during rapid eye movements. Ravagnati et al (51) reported that in man the unit activities of the hippocampus gyrus and of the amygdala show an increase in their discharge frequency during REM sleep, these frequencies being greater than those observed during slow wave sleep or wakefulness. Velluti and Monti (52) found that in the cat there was a direct relation between the activity of the reticularis pontis caudalis nucleus and that of the basal nucleus of the amygdala during the rapid eye movements of REM when they recorded the changes in P0 2 in those structures.…”

Section: Discussionmentioning

confidence: 99%

Phasic Activity of the Basolateral Amygdala, Cingulate Gyrus, and Hippocampus During REM Sleep in the Cat

Calvo

Fernández-Guardiola

1984

Sleep

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Summary: We analyzed the electrical activity of the basolateral amygdala (BLA), anterior and posterior regions of the cingulate gyrus (A-CG and P-CG) , the dorsal hippocampus (DH) , the anterior ventral thalamic nucleus (AVTN), and the sensory motor cortex during the rapid eye movements and ponto-geniculo-occipital (PGO) activity of REM sleep in cats in chronic preparation. Polygraphic recordings and computational peri event averages using the phasic contractions of the lateral rectus muscle (LR) of the eyeball as the triggering signal of the analysis were performed. We observed biphasic potentials (200--300 ms) of variable amplitude, related to the phasic phenomena of REM sleep, in the BLA, A-CG, P-CG, DH, and AVTN. The latencies of the potentials of these regions were always greater than those of the geniculate PGO activities. We propose that the recorded limbic potentials resulted from propagation of PGO activity and that this phenomenon may reflect the limbic structure of the hallucinatory, vegetative, and emotional components of REM sleep. Key Words: Sleep--Amygdala-Hippocampus-Gyrus cinguli-REM sleep--Ponto-geniculo-occipital activity.Jouvet and Michel (1) demonstrated the existence of monophasic spikes in cats at the level of the pons during REM sleep. This electrical activity is propagated from the pontine region (2,3) to the cortical and subcortical structures of the visual system (4--6). Jeannerod et al. (7) were the first to call the phenomenon ponto-geniculo-occipital (PGO) activity. Ponto-geniculo-occipital activity has been studied thoroughly in the oculomotor system (8-12).In man emotional changes, mnestic phenomena of a personal and conceptual type and vegetative changes accompany the rapid eye movements of REM sleep. Jouvet et al. (13), Snyder et al. (14), Baust and Bohenert (15), Welch and Richardson (16), and FernandezGuardiola et al. (17) have described variations in the frequency of both cardiac and respiratory rates related to rapid eye movements.The functions related to emotional and vegetative changes are integrated in the limbic system and in the hypothalamus. Electrical stimulation of these structures elicits emotional

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Activity of Human Hippocampal Formation and Amygdala Neurons During Sleep

Cited by 28 publications

References 0 publications

Single neuron burst firing in the human hippocampus during sleep

Single neuron burst firing in the human hippocampus during sleep

A neurobiological model for near-death experiences

Phasic Activity of the Basolateral Amygdala, Cingulate Gyrus, and Hippocampus During REM Sleep in the Cat

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