Activity of elaeochytrin A from Ferula elaeochytris on leukemia cell lines

In vitro screening of tumoricidal properties of international medicinal herbs: part II

“…& DR. contains a compound called lapiferin which is responsible for cytotoxic effects on human MCF-7 breast cancer cells (Gamal-Eldeen and Hegazy, 2010). Extracts derived from the roots of F. elaeochytris Korovin contain 6-anthraniloyljaeschkeanadiol which exerts cytotoxic properties on K562R imatinib-resistant human chronic myeloid leukemia and a dasatinib-resistant mouse leukemia cell line (Alkhatib et al , 2008). Similarly, F. szowitsiana DC (umbelliprenin) exerts tumoricidal effects on malignant melanoma, cell lung carcinoma and prostate carcinoma (Barthomeuf et al , 2008), where F. szowitziana DC contains conferone, a sesquiterpene coumarin known to inhibit protein transporter P-glycoprotein indicating potential in treating multidrug resistant carcinoma (Barthomeuf et al , 2006).…”

Natural daucane esters induces apoptosis in leukaemic cells through ROS production

“…The activity of the isolated compounds are reported in Table 1 and some preliminary evaluation of structure activity relationships can be traced considering the measured GI 50 values and comparing the values with the one obtained in our previous work (Dall 'Acqua et al, 2011). Other authors reported the antileukemic activity of other daucane derivatives, and the 6-anthraniloyljaeschkeanadiol (elaeochytrin A), isolated from Ferula elaeochytris was active against K562R (imatinib-resistant) human chronic myeloid leukaemia and DA1-3b/M2(BCR-ABL) (dasatinib-resistant) mouse leukemia cell line, and HL-60 cell line and was non toxic against normal peripheral blood mononuclear cells (Alkhatib et al, 2008).…”

Novel thermosensitive poly (N-isopropylacrylamide-co-vinylpyrrolidone-co-methacrylic acid) nanosystems for delivery of natural products.

“…The collapsed shell might induce the deformation of the core-shell structure, exposing Farnesiferol C molecules to the external in vitro release medium and thus accelerating drug release. Solubilities and other physicochemical properties of nanoparticles are essential requirements for drug advancement from pharmaceutical technology towards clinical trials and applications [25,26,27]. Given the integration of nanomaterials with herbal medicine for providing more efficient medications, we focused on exploitation of bioactive derivatives from plant resources that provide huge potential for novel biologically active compounds such as antiinflammatory, anticancer, antiviral, antibacterial, and antioxidant agents.…”