Activity of Cytochrome <i>c</i> Oxidase in the Right and Left Ventricular Myocardium of Male and Female Rats Exposed To Intermittent High Altitude Hypoxia<sup>a</sup>

Stieglerová, A; Drahota, Z; Houštěk, Josef; Milerová, Marie; Pelouch, V.; Ošťádal, B

doi:10.1111/j.1749-6632.1999.tb09242.x

Cited by 9 publications

(3 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The effect of hypoxic stresses on cardiac cytochrome c oxidase activity is still controversial. Hypoxia/ischemia appears to lead to an acute reversible inhibition of cytochrome oxidase activity [16,17], but in some other studies, cytochrome c oxidase activities in the right ventricles of rats after chronic highaltitude hypoxia were not affected by hypoxia [18]. In the current study, 4 weeks intermittent hypoxia had no effect on cytochrome c oxidase activities whereas 8 weeks intermittent hypoxia proceed in the inhibition of cytochrome c oxidase activity.…”

Section: Changes Of Component Protein Levels Of Mitochondriadependentcontrasting

confidence: 66%

Effects of long-term intermittent hypoxia on mitochondrial and Fas death receptor dependent apoptotic pathways in rat hearts

Lee

Kuo

Lin

et al. 2007

International Journal of Cardiology

View full text Add to dashboard Cite

Section: Changes Of Component Protein Levels Of Mitochondriadependentcontrasting

confidence: 66%

Effects of long-term intermittent hypoxia on mitochondrial and Fas death receptor dependent apoptotic pathways in rat hearts

Lee

Kuo

Lin

et al. 2007

International Journal of Cardiology

View full text Add to dashboard Cite

“…It was proposed that COX might function as an oxygen sensor in the intact cells. This concept is supported by studies of intermittent high altitude hypoxia in rats (Stieglerova et al 1999). Hypoxia induced an increase of the total activity of COX in the right ventricle compared with the left ventricle.…”

Section: Discussionmentioning

confidence: 93%

Mitochondrial abnormalities in dermatomyositis: characteristic pattern of neuropathology

et al. 2004

View full text Add to dashboard Cite

The objective of the work described in this paper was to evaluate mitochondrial abnormalities in perifascicular atrophic fibers in muscle biopsies from patients with dermatomyositis (DM). We localized cytochrome c oxidase (COX) and succinate dehydrogenase (SDH) histochemically in muscle biopsies of 12 patients with DM, and 12 control patients with neurogenic atrophy. These two histochemical techniques were also combined on single tissue sections in order to accentuate any COX-negative fibers. Eleven out of 12 patients (91.6%) with DM showed histochemical evidence of mitochondrial dysfunction in perifascicular distribution. Similar abnormalities in histochemical staining were not seen in comparably sized myofibers that were atrophic due to denervation. It is concluded that abnormal SDH and COX histochemical activities in atrophic perifascicular fibers are characteristic of dermatomyositis. These abnormal staining characteristics could not be accounted for solely by myofiber atrophy, or by generalized abnormalities in histochemical staining.

show abstract

“…Moreover, this increase in COX-2 protein and activity is accompanied by an increase in tissue PGE 2 levels and neurobehavioral deficits in the acquisition and retention of a spatial task in the water maze. Also, the total cytochrome-c oxidase activity has been reported to increase in the right ventricular myocardium of adult rats exposed to intermittent high-altitude hypoxia (5,000 m, 8 h/day for a total of 32 exposures), suggesting that IH induces an increase in the capacity of the oxidative metabolism (82).…”

Section: Stress-related Proteinsmentioning

confidence: 99%

Analysis of expression and posttranslational modification of proteins during hypoxia

Kumar

Klein²

2004

Journal of Applied Physiology

View full text Add to dashboard Cite

The cellular responses to hypoxia are complex and characterized by alterations in the expression of a number of genes, including stress-related genes and corresponding proteins that are necessary to maintain homeostasis. The purpose of this article is to review previous and recent studies that have examined the changes in the expression and posttranslational modification of proteins in response to chronic sustained and intermittent forms of hypoxia. A large number of studies focused on the analysis of either the single protein or a subset of related proteins using one-dimensional gel electrophoresis to separate a complex set of proteins from solubilized tissues or cell extracts, followed by immunostaining of proteins using antibodies that are specific to either native or posttranslationally modified forms. On the other hand, only a limited number of studies have examined the global perturbations on protein expression by hypoxia using proteomics approach involving two-dimensional electrophoresis coupled with mass spectrometry. Results derived from specific protein analysis of a variety of tissues and cells showed that hypoxia, depending on the duration and severity of the stimulus, affects the level and the state of posttranslational modification of a subset of proteins that are associated with energy metabolism, stress response, cell injury, development, and apoptosis. Some of these earlier findings are further corroborated by recent studies that utilize a global proteomics approach, and, more importantly, results from these proteomics investigations on the effects of hypoxia provide new protein targets for further functional analysis. The anticipated new information stems from the analysis of expression, and posttranslational modification of these novel protein targets, along with gene expression profiles, offers exciting new opportunities to further define the mechanisms of cellular responses to hypoxia and to control more effectively the clinical consequences of prolonged or periodic lack of oxygen.

show abstract

Activity of Cytochrome c Oxidase in the Right and Left Ventricular Myocardium of Male and Female Rats Exposed To Intermittent High Altitude Hypoxia^a

Cited by 9 publications

References 27 publications

Effects of long-term intermittent hypoxia on mitochondrial and Fas death receptor dependent apoptotic pathways in rat hearts

Effects of long-term intermittent hypoxia on mitochondrial and Fas death receptor dependent apoptotic pathways in rat hearts

Mitochondrial abnormalities in dermatomyositis: characteristic pattern of neuropathology

Analysis of expression and posttranslational modification of proteins during hypoxia

Contact Info

Product

Resources

About

Activity of Cytochrome c Oxidase in the Right and Left Ventricular Myocardium of Male and Female Rats Exposed To Intermittent High Altitude Hypoxiaa

Cited by 9 publications

References 27 publications

Effects of long-term intermittent hypoxia on mitochondrial and Fas death receptor dependent apoptotic pathways in rat hearts

Effects of long-term intermittent hypoxia on mitochondrial and Fas death receptor dependent apoptotic pathways in rat hearts

Mitochondrial abnormalities in dermatomyositis: characteristic pattern of neuropathology

Analysis of expression and posttranslational modification of proteins during hypoxia

Contact Info

Product

Resources

About

Activity of Cytochrome c Oxidase in the Right and Left Ventricular Myocardium of Male and Female Rats Exposed To Intermittent High Altitude Hypoxia^a