Activity of Compound Agrimony Enteritis Capsules against invasive candidiasis: Exploring the differences between traditional Chinese medicine prescriptions and its main components in the treatment of diseases

Li, Jun; Jin, Zehua; Li, Jiasheng; Su, Liu-Yan; Wang, Ying-Xian; Zhang, Yi; Qin, Dingmei; Rao, G. Venkata; Wang, Ruirui

doi:10.1016/j.jep.2021.114201

Cited by 6 publications

(2 citation statements)

References 36 publications

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“…TCM has been widely used in the treatment of diseases, and research has also found that Xiaoyaosan can increase the abundance of Bacteroides to treat colorectal cancer (Zhao et al, 2021 ). Compound Agrimony Enteritis Capsules can increase the relative abundance of probiotics in Bacteroides and inhibit IL‐6 production (Li et al, 2021 ). In addition, the TCM Gui‐fu‐di‐huang‐wan can increase the abundance of Bacteroides in the body and regulate the microbiota structure and metabolite levels (Jing et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

Baogong decoction treats endometritis in mice by regulating uterine microbiota structure and metabolites

Wang

et al. 2022

Microbial Biotechnology

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Endometritis is persistent inflammation caused by bacteria, which can lead to infertility. Although traditional Chinese medicine (TCM) has been used to treat endometritis, the underlying mechanism is still unclear. Here, Baogong Decoction (BGD), a TCM compound, was used to treat mouse endometritis induced by Escherichia coli (E. coli), and then 16S rRNA sequencing and non-targeted metabolomics were used to investigate the change of uterine microbiota and metabolomes in serum and uterine after BGD treatment.Finally, the therapeutic effect of potential metabolites for treating mouse endometritis screened by combined omics analyses was verified using pathological model. The results showed that BGD treatment could effectively treat endometritis associated with the increasing relative abundance of Firmicutes, Bacteroides, Lactobacillus and Lactococcus, and the decreasing relative abundance of Cupriavidus and Proteobacteria. 133 and 130 metabolites were found to be potential biomarkers in serum and uterine tissue respectively.In serum and tissues, dehydroepiandrosterone (DHEA) and catechol were significantly increased in the BGD treatment versus the inflammation group.Results of combined omics analyses demonstrated that DHEA was positively correlated with changes in microbiota. Results of pathological model demonstrated that DHEA could cure endometritis effectively associated with the decreasing infiltration of inflammatory cells and expression of inflammatory factors in the uterus. In summary, our results demonstrated that BGD could cure endometritis in mice by modulating the structure of the uterine microbiota and its metabolites, in which DHEA may be one of the main components of the therapeutic effect of BGD.

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Section: Discussionmentioning

confidence: 99%

Baogong decoction treats endometritis in mice by regulating uterine microbiota structure and metabolites

Wang

et al. 2022

Microbial Biotechnology

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“…These agents have a fungicidal action against most Candida strains and can be used in the treatment of invasive candidiasis (Fig. 1) [15].…”

Section: Developmentmentioning

confidence: 99%

Frontiers in the search for new antimicrobials: new perspectives

Silva¹,

Martins²,

Evangelho³

et al. 2023

Braz. J. Develop.

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Infections caused by bacteria and fungi resistant to antimicrobials are one of the main public health problems in the world. These microorganisms are associated with high rates of morbidity and mortality and also with high hospital costs. Their emergence and spread are closely related to the excessive and inappropriate use of antimicrobials in medical and veterinary practices and in animal production. For the treatment of Candida spp. there are few classes of antifungals available for treatment, the classes being: azole derivatives, polyenes and echinocandins. The class of azoles includes imidazole derivatives (ketoconazole, miconazole, clotrimazole), triazole derivatives (fluconazole, itraconazole and voriconazole) and posaconazole. These drugs can be used for topical us as well as in the treatment and prophylaxis of invasive infections. The wide use of these drugs has led to a strong selection of strains resistant to them, which is increasingly growing. The need to produce new antimicrobial drugs requires different strategies, among which we highlight the importance of bioprospecting for secondary metabolites of environmental bacteria and fungi with potential antimicrobial activity.

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Therapy of traditional Chinese medicine in Candida spp. and Candida associated infections: A comprehensive review

Liu,

Shao

2024

Fitoterapia

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Activity of Compound Agrimony Enteritis Capsules against invasive candidiasis: Exploring the differences between traditional Chinese medicine prescriptions and its main components in the treatment of diseases

Cited by 6 publications

References 36 publications

Baogong decoction treats endometritis in mice by regulating uterine microbiota structure and metabolites

Baogong decoction treats endometritis in mice by regulating uterine microbiota structure and metabolites

Frontiers in the search for new antimicrobials: new perspectives

Therapy of traditional Chinese medicine in Candida spp. and Candida associated infections: A comprehensive review

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