Activity of biogenic silver nanoparticles against isolates of Prototheca species from bovine mastitis

Ely, Valessa Lunkes; Pereira, Daniela Isabel Brayer; Costa, Mateus Matiuzzi da; Panagio, Luciano Aparecido; Nakasato, Gerson; Reis, Guilherme Fonseca; Cargnelutti, Juliana Felipetto; Sangioni, Luís Antônio; Botton, Sônia de Ávila

doi:10.1111/lam.13696

Cited by 3 publications

(1 citation statement)

References 19 publications

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“…In parallel, new preparations continue to be tested for their anti- Prototheca activity. Recent studies have shown various chemical substances as new, promising options for the treatment of protothecosis, including iodine-containing carbamates ( 15 ), antimicrobial peptides ( 41 ), and silver nanoparticles ( 42 , 43 ). In this study, EFZ, having shown the highest activity against the Prototheca algae, should be considered to be a potential therapeutic alternative for human protothecosis.…”

Section: Methodsmentioning

confidence: 99%

Drug Susceptibility Profiling of Prototheca Species Isolated from Cases of Human Protothecosis

Proskurnicka

Żupnik

Bakuła

et al. 2023

Antimicrob Agents Chemother

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Section: Methodsmentioning

confidence: 99%

Drug Susceptibility Profiling of Prototheca Species Isolated from Cases of Human Protothecosis

Proskurnicka

Żupnik

Bakuła

et al. 2023

Antimicrob Agents Chemother

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Protothecosis in Veterinary Medicine: a minireview

Ely

Espíndola

Barasuol

et al. 2023

Letters in Applied Microbiology

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Protothecosis is an important infection caused by Prototheca spp., an alga that affect humans and animals. Prototheca spp. infections determine losses of production and quality of life for the affected animals. In this disease, prevention and early diagnosis are essential to avoid the spread of the agent to susceptible hosts. This review aimed to assemble the reported cases of protothecosis in Veterinary Medicine, highlighting Prototheca species involved in the infections, the main animal species affected, as well as the clinical manifestations, diagnosis, and treatment. Our findings showed that protothecosis has been reported in various domestic and wild animal species, presenting diverse clinical manifestations, including mastitis in cows, respiratory manifestations in goats and cats, and a wide range of clinical signs in dogs. The clinical diagnosis and treatment of Prototheca spp. infections are difficult and infected animals are frequently discarded or euthanized. Due to the importance of this infection, protothecosis must be considered an important differential diagnosis in routine clinical Veterinary Medicine.

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Prototheca spp. in Bovine Infections

Nardoni,

Mancianti

2023

Encyclopedia

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Prototheca microalgae, although still considered uncommon etiologic agents, represent an insidious intruder, threatening cattle herd health and determining productive losses. Increasing numbers of clinical cases globally identified would indicate these microalgae as emerging pathogens. They can be isolated from a wide variety of environmental and non-environmental sources, due also to their ability to produce biofilm. This ability to spread and contaminate a huge variety of substrates, as well as the high resistance to elevated temperatures, renders Prototheca prevention a very hard task. In addition, early infection signs are subtle and difficult to detect. The poor response to conventional antimycotic drugs represents an additional challenge when facing this infection. Although it would seem unrealistic to completely eradicate the exposure risk of cows to these microalgae, the adoption of proper on-farm protocols and management, with the highest attention to hygiene measures, would be beneficial in reducing the magnitude of this problem. Keeping the attention focused on early diagnosis, together with the development of new, alternative, and effective agents and formulations, would be strongly advised to prevent, treat, and control Prototheca infections.

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Activity of biogenic silver nanoparticles against isolates of Prototheca species from bovine mastitis

Cited by 3 publications

References 19 publications

Drug Susceptibility Profiling of Prototheca Species Isolated from Cases of Human Protothecosis

Drug Susceptibility Profiling of Prototheca Species Isolated from Cases of Human Protothecosis

Protothecosis in Veterinary Medicine: a minireview

Prototheca spp. in Bovine Infections

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