Activity of Alkanediol Alkanoates against Pathogenic Plant Fungi Rhizoctonia solani and Sclerotium rolfsii

Abstract

Thirty known dialkanoates of ethylene, propylene and diethylene glycols were synthesized by reacting the glycols with acyl chlorides and their structures confirmed by IR, NMR and mass spectral analyses. They exhibited significant antifungal activity against two phytopathogenic fungi Rhizoctonia solani Kuehn and Sclerotium rolfsii Sacc in a dose dependent manner. Propylene glycol dipentanoate was the most active against R. solani. followed by diethylene glycol dibutanoate and ethylene glycol dibutanoate. Against S. rolfsii ethylene glycol diheptanoate was found to be most active followed by diethylene glycol diisobutanoate As compared to the standard reference benomyl (EC 50 5.16 µg/mL), the potential alkanediol dialkanoates showed EC 50 in the range of 33-60 µg/mL.

Antifungal and phytotoxic activity of essential oil from root of Senecio amplexicaulis Kunth. (Asteraceae) growing wild in high altitude-Himalayan region

“…The antifungal activity of the compounds was evaluated in Vitro by poisoned food technique against against five phytopathogenic fungi, Sclerotium rolfsii (ITCC 6263), Macrophomina phaseolina (ITCC 6267), Rhizoctonia solani (ITCC 4502), Pythium debaryanum (ITCC 95) and Fusarium oxysporum (ITCC 6246) (Shukla et al, 2012). Briefly, the ready-made PDA medium (39 g) was suspended in 1000 ml of distilled water and heated to boiling to completely dissolve the medium.…”

Synthesis, Antifungal Activity and Structure-Activity Relationships of Vanillin Oxime-N-O-Alkanoates

“…The products were further purified by either CC over silica gel using n-hexane and nhexane/acetone as the eluting solvent or by prep-TLC. Antifungal activity of the compounds was carried out employing the poisoned food technique using 4% PDA medium by the macrodilution method [17]. A stock solution of each compound was prepared by dissolving 130 mg in 2 mL acetone.…”