Activity measurements of the radionuclides ^99mTc, ¹⁸F and ⁶⁴Cu for the POLATOM, Poland, in the ongoing comparisons BIPM.RI(II)-K4 series and KCRV update in the corresponding BIPM.RI(II)-K1 comparison

Abstract

Main text In 2016, comparisons of activity measurements of 99mTc, 18F and 64Cu using the Transfer Instrument of the International Reference System (SIRTI) took place at the National Centre for Nuclear Research, Radioisotope Centre (POLATOM, Poland). Ampoules containing about 33 kBq of 99mTc, 28 kBq of 18F and 110 kBq of 64Cu solutions were measured in the SIRTI for about 3, 5 and 1.5 half-lives, respectively. The POLATOM standardized the activity in the ampoules by 4(LS) coincidence measurements. The comparisons, identifiers BIPM.RI(II)-K4.Tc-99m, BIPM.RI(II)-K4.F-18 and BIPM.RI(II)-K4.Cu-64, are linked to the corresponding BIPM.RI(II)-K1.Tc-99m, BIPM.RI(II)-K1.F-18 and BIPM.RI(II)-K1.Cu-64 comparisons. The BIPM.RI(II)-K1 99mTc and 18F key comparison reference values have been updated to include the latest BIPM.RI(II)-K4 linked results and degrees of equivalence for both comparison series have been evaluated. To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database https://www.bipm.org/kcdb/. The final report has been peer-reviewed and approved for publication by the CCRI, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).

Data reconciliation connected to guard bands to set specification limits related to risk assessment for radiopharmaceutical activity

“…For Tc-99 m, the supplier and receiver measurements were 25.0 mCi and 24.4 mCi (no correction in time), respectively, considering a time difference between them of - 10 min and a typical standard uncertainty (k = 1) of 0.72 % [ 75 ]. Based on the connected approaches of DR and guard band, the consumer risk for the supplier, receiver and reconciled measurements were, respectively, 20.2 % (not conforming to the specification), 6.15 % (not conforming to the specification) and 4.64 % (24.8 mCi–24.9 mCi, considering a standard deviation, conforming to the specification), generating reliable specification limits of 24.6 mCi–25.2 mCi, Fig.…”

News from the BIPM laboratories—2022

“…This remote mode has been used successfully for SIRTI comparisons in 2021 at the PTB (Germany) and in 2022 at the KRISS (Republic of Korea). One comparison report was published [18] and a second produced. The SIRTI has already been linked to the SIR for 18 F, 64 Cu and 99m Tc by carrying out measurements at the BIPM Headquarters in the two systems.…”

“…One comparison report was published [18] and a second produced. The SIRTI has already been linked to the SIR for 18 F, 64 Cu and 99m Tc by carrying out measurements at the BIPM Headquarters in the two systems. In 2019 and 2021-2022, further links to the SIR were measured for 123 I and 153 Sm at the BIPM Headquarters and at the PTB in remote mode, respectively.…”