Activity in Functional Cortical Networks Temporally Associated with Postural Instability

Varghese, Jessy Parokaran; Staines, Richard; McIlroy, William E.

doi:10.1016/j.neuroscience.2019.01.008

Cited by 40 publications

(62 citation statements)

References 65 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…We observed greater modulation of sensorimotor beta oscillations evoked by larger, more challenging balance perturbations, and in individuals with lower balance ability. In contrast to prior studies that have observed beta power modulation beginning prior to the onset of unpredictable balance perturbations (Nakamura et al, 2020;Peterson & Ferris, 2018Solis-Escalante et al, 2019;Varghese et al, 2014Varghese et al, , 2019, we found modulation of beta power occurred ~50 ms after the onset of perturbations. Further the time course of evoked beta power was similar to that of evoked balance-correcting muscle activity.…”

Section: Discussioncontrasting

confidence: 99%

“…In contrast to the transient N1 potential that reflects more general neural features of attention (C. E. Little & Woollacott, 2015;Quant et al, 2004) or threat perception (Adkin et al, 2008;Mochizuki et al, 2010), cortical beta power has greater potential for involvement in balance-correcting behavior because it remains elevated throughout balance recovery with a time course comparable to the balance-correcting motor response. Prior studies have shown beta power modulation beginning prior to the onset of unpredictable balance perturbations (Nakamura et al, 2020;Peterson & Ferris, 2018Solis-Escalante et al, 2019;Varghese et al, 2014Varghese et al, , 2019, making it unclear whether the modulation was occurring in anticipation of, rather than in response to, the balance perturbations. The apparent modulation of beta power prior to perturbation onset in these cases may have resulted from the loss of temporal resolution that occurs with the use of larger sliding time windows that are necessary for the inclusion of lower oscillatory frequencies (e.g.…”

Section: Increased Cortical Recruitment With Increasing Balance Diffimentioning

confidence: 99%

“…While beta oscillations have been linked to sensorimotor information processing and motor control, beta oscillatory activity in the context of balance-correcting behavior and associations with balance ability are poorly understood. Previous studies have consistently demonstrated that cortical beta activity over central midline scalp regions is modulated during standing balance recovery (Nakamura et al, 2020;Peterson & Ferris, 2018Solis-Escalante et al, 2019;Varghese et al, 2014Varghese et al, , 2019, though there is some discrepancy regarding the directionality of change that may originate from differences in the perturbation and analysis methodologies.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Cortical beta oscillatory activity evoked during reactive balance recovery scales with perturbation difficulty and individual balance ability

Ghosn

Palmer

Borich

et al. 2020

Preprint

View full text Add to dashboard Cite

I.AbstractCortical beta oscillations (13-30 Hz) reflect sensorimotor cortical activity, but have not been fully investigated in balance recovery behavior. We hypothesized that more challenging balance conditions would lead to greater recruitment of cortical sensorimotor brain regions for balance recovery. We predicted that beta power would be enhanced when balance recovery is more challenging, either due to more difficult perturbations or due to lower intrinsic balance ability. In 19 young adults, we measured beta power evoked over motor cortical areas (Cz electrode) during 3 magnitudes of backward support-surface translational perturbations using electroencephalography. Peak beta power was measured during early (50-150 ms), late (150-250 ms), and overall (0-400 ms) time bins, and wavelet-based analyses quantified the time course of evoked beta power and agonist and antagonist ankle muscle activity. We further assessed the relationship between individual balance ability measured in a challenging beam walking task and perturbation-evoked beta power within each time bin. In balance perturbations, cortical beta power increased ∼50 ms after perturbation onset, demonstrating greater increases with increasing perturbation magnitude. Balance ability was negatively associated with peak beta power in only the late (150-250 ms) time bin, with higher beta power in individuals who performed worse in the beam walking task. Additionally, the time course of cortical beta power followed a similar waveform as the evoked muscle activity, suggesting these evoked responses may be initially evoked by shared underlying mechanisms. These findings support the active role of sensorimotor cortex in balance recovery behavior, with greater recruitment of cortical resources under more challenging balance conditions. Cortical beta power may therefore provide a biomarker for engagement of sensorimotor cortical resources during reactive balance recovery and reflect the individual level of balance challenge.

show abstract

Section: Discussioncontrasting

confidence: 99%

Section: Increased Cortical Recruitment With Increasing Balance Diffimentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Cortical beta oscillatory activity evoked during reactive balance recovery scales with perturbation difficulty and individual balance ability

Ghosn

Palmer

Borich

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…These authors interpreted the multifocal theta power enhancement as activity of a cortical network that is involved in detecting postural threats and initiating adequate postural responses. Moreover, Varghese et al (2019) speculated upon the existence of a cortical balance control network. Their assumption was based on widespread topological rearrangements in functional cortical connectivity within delta, theta, alpha, and beta frequency bands during the performance of reactive balance tasks.…”

Section: Theta Frequency Bandmentioning

confidence: 99%

“…Moreover, Solis-Escalante et al (2019) reported that broadband power increases were accompanied by concomitant multifocal increases in theta frequency band power. Accordingly, the current state of postural stability/instability could be reflected in the activity level of a cortical network that is involved in postural control (Solis-Escalante et al 2019;Varghese et al 2019). There is evidence that changes in the EEG power spectrum due to postural instability occur predominantly in the theta and alpha frequency bands.…”

Section: Introductionmentioning

confidence: 99%

Balance task difficulty affects postural sway and cortical activity in healthy adolescents

2020

View full text Add to dashboard Cite

Electroencephalographic (EEG) research indicates changes in adults' low frequency bands of frontoparietal brain areas executing different balance tasks with increasing postural demands. However, this issue is unsolved for adolescents when performing the same balance task with increasing difficulty. Therefore, we examined the effects of a progressively increasing balance task difficulty on balance performance and brain activity in adolescents. Thirteen healthy adolescents aged 16-17 year performed tests in bipedal upright stance on a balance board with six progressively increasing levels of task difficulty. Postural sway and cortical activity were recorded simultaneously using a pressure sensitive measuring system and EEG. The power spectrum was analyzed for theta (4-7 Hz) and alpha-2 (10-12 Hz) frequency bands in pre-defined frontal, central, and parietal clusters of electrocortical sources. Repeated measures analysis of variance (rmANOVA) showed a significant main effect of task difficulty for postural sway (p < 0.001; d = 6.36). Concomitantly, the power spectrum changed in frontal, bilateral central, and bilateral parietal clusters. RmANOVAs revealed significant main effects of task difficulty for theta band power in the frontal (p < 0.001, d = 1.80) and both central clusters (left: p < 0.001, d = 1.49; right: p < 0.001, d = 1.42) as well as for alpha-2 band power in both parietal clusters (left: p < 0.001, d = 1.39; right: p < 0.001, d = 1.05) and in the central right cluster (p = 0.005, d = 0.92). Increases in theta band power (frontal, central) and decreases in alpha-2 power (central, parietal) with increasing balance task difficulty may reflect increased attentional processes and/or error monitoring as well as increased sensory information processing due to increasing postural demands. In general, our findings are mostly in agreement with studies conducted in adults. Similar to adult studies, our data with adolescents indicated the involvement of frontoparietal brain areas in the regulation of postural control. In addition, we detected that activity of selected brain areas (e.g., bilateral central) changed with increasing postural demands.

show abstract

Graph‐theoretical analysis of EEG functional connectivity during balance perturbation in traumatic brain injury: A pilot study

Handiru

Alivar

Hoxha

et al. 2021

Human Brain Mapping

View full text Add to dashboard Cite

Traumatic brain injury (TBI) often results in balance impairment, increasing the risk of falls, and the chances of further injuries. However, the underlying neural mechanisms of postural control after TBI are not well understood. To this end, we conducted a pilot study to explore the neural mechanisms of unpredictable balance perturbations in 17 chronic TBI participants and 15 matched healthy controls (HC) using the EEG, MRI, and diffusion tensor imaging (DTI) data. As quantitative measures of the functional integration and segregation of the brain networks during the postural task, we computed the global graph‐theoretic network measures (global efficiency and modularity) of brain functional connectivity derived from source‐space EEG in different frequency bands. We observed that the TBI group showed a lower balance performance as measured by the center of pressure displacement during the task, and the Berg Balance Scale (BBS). They also showed reduced brain activation and connectivity during the balance task. Furthermore, the decrease in brain network segregation in alpha‐band from baseline to task was smaller in TBI than HC. The DTI findings revealed widespread structural damage. In terms of the neural correlates, we observed a distinct role played by different frequency bands: theta‐band modularity during the task was negatively correlated with the BBS in the TBI group; lower beta‐band network connectivity was associated with the reduction in white matter structural integrity. Our future studies will focus on how postural training will modulate the functional brain networks in TBI.

show abstract

Activity in Functional Cortical Networks Temporally Associated with Postural Instability

Cited by 40 publications

References 65 publications

Cortical beta oscillatory activity evoked during reactive balance recovery scales with perturbation difficulty and individual balance ability

Cortical beta oscillatory activity evoked during reactive balance recovery scales with perturbation difficulty and individual balance ability

Balance task difficulty affects postural sway and cortical activity in healthy adolescents

Graph‐theoretical analysis of EEG functional connectivity during balance perturbation in traumatic brain injury: A pilot study

Contact Info

Product

Resources

About