Activity guided isolation of antioxidants from the leaves of Ricinus communis L.

Singh, Pradeep Pratap; Ambika, .; Chauhan, S. M. S.

doi:10.1016/j.foodchem.2008.10.020

Cited by 68 publications

(34 citation statements)

References 18 publications

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“…Hence the antioxidant activity of Ricinus communis leaves is probably due the presence of flavonoids and tannins in the 50 % methanolic extract. 32 The DPPH (1, 1-diphenyl-2-picryl hydrazyl)-mediated in vitro study reveals that gallic acid, quercetin, gentisic acid, rutin, epicatechin and ellagic acid are the major phenolic compounds responsible for the antioxidant activity of the dry leaves of Ricinus communis Linn 33 .…”

Section: Urubooka (Ricinus Communis Linn)mentioning

confidence: 99%

Antioxidant Activity of Madhuraprabhava Drugs Delineated in Madhuraskandha of Charaka's Materia Medica

Bhuvad¹,

Nishteswar²

2014

J Biol Sci Opin

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Acharya Charaka had mentioned Madhuraskandha in the context of Asthapana Basti dravya. There are total 85 drugs mentioned in the Madhuraskandha. The drugs included in Madhuraskandha usually possess Madhurarasa or Madhuravipaka and Madhuraprabhava. Madhuraprabhava is the phenomenon in which the drug shows the action attributed to Madhurarasa or Madhuravipaka though it does not contain either of them. In Madhuraskandha, there are in total 25 drugs which exercise their action through Madhuraprabhava. In Ayurvedic pharmacology, Prabhava is referred as inexplicable principle. But, basing upon the active constituents of the medicinal plants their respective activities can be explained. The active constituents of plants have been recently isolated. They have been divided into16 main groups viz. alkaloids, anthocyanin, anthraquinones, glycosides, minerals etc. The active constituents in plants are the chemicals that have a medicinal effect on the body. Rasayana dravyas mainly possess Madhurarasa. The Rasayana activity (antioxidant activity one of the indices of Rasayana Karma) is well explained in the light of presence of phenol compounds, triterpenoids, flavonoids, gallic acids etc. In the present study, the anti-oxidant activity of the Madhuraskandha dravyas who act through their Madhuraprabhava can be explained by the presence of terpenoid, flavonoids and total phenol content etc. A review of such reported researches have been made to explain the activities of drugs having Madhuraprabhava.

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Section: Urubooka (Ricinus Communis Linn)mentioning

confidence: 99%

Antioxidant Activity of Madhuraprabhava Drugs Delineated in Madhuraskandha of Charaka's Materia Medica

Bhuvad¹,

Nishteswar²

2014

J Biol Sci Opin

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“…The AF was subjected to column chromatography (CC) using silica gel and a gradient of dichloromethane-methanol (95:5 to 5:95) as eluent to yield the following compounds: benzoic acid (1), p-hydroxybenzoic acid (2), protocatechuic acid (3), and quercetin (4). The fractions were then subjected to further CC over the same system resulting in the isolation of two catechins: (-)-epiafzelechin protocatechuate (5) and (-)-epiafzelechin p-hydroxybenzoate (6). The late fractions of the previous separation were subjected to CC over cellulose using ethanol as eluent to give (-)-epicatechin (7).…”

Section: Plant Material Extraction and Isolationmentioning

confidence: 99%

“…The IC 50 was calculated from the Hill Plot (GraphPad Prism v4). Vol 15 No 6 Seccon et al Antioxidant activity and low cytotoxicity of extracts and isolated compounds from Araucaria angustifolia dead bark Lipoperoxidation induced by ascorbyl radical Lipid peroxidation was induced by the reaction system Fe/ascorbate, which generates the ascorbyl radical (Asc • •-). To the reaction medium containing 25 mg/ml liposomes in 0.1 M Tris-HCl (pH 7.4), FeSO 4 (25 µM) and ascorbate (500 µM) were added.…”

Section: Lipoperoxidation Induced By Uv Lightmentioning

confidence: 99%

Antioxidant activity and low cytotoxicity of extracts and isolated compounds fromAraucaria angustifoliadead bark

et al. 2010

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The antioxidant activities of the extract and its relevant fraction as well as isolated compounds from the dead bark of Araucaria angustifolia are presented. This tree represents the Mixed Ombrophile Forest, which is endangered due to extensive logging. The dead bark of Araucaria is naturally discarded by the tree, and its hydroalcoholic crude extract has exhibited protective qualities against stress induced by H(2)O(2) in cell culture. Using several in vitro models, here we describe the antioxidant potential of the crude extract and its component ethyl acetate fraction and also of some compounds isolated from the ethyl acetate fraction. We provide the first description of the isolation of two natural product afzelechin derivatives. The extract and isolated compounds, particularly epiafzelechin protocatechuate (5), displayed very high antioxidant activity, as did compound 4, quercetin, which is well known for its antioxidant properties. In a DPPH assay, compound 5 exhibited an IC(50) of 0.7 μM; in a lipid peroxidation assay; IC(50) values of 21 μM and 35 μM were obtained when the oxidation was induced by UV and ascorbate free radicals, respectively.

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“…In the Indian system of medicine, the leaf, root and seed oil of this plant have been used for the treatment of inflammation and liver disorders. The plant has been found to be useful in hepatoprotective [15], anti filarial [16], antioxidant [17], antiasthmatic [18] and antimicrobial [19] activities. Roots of this plant showed anti-inflammatory and free radical scavenging, anti-fertility, antidiabetic, and antimicrobial properties.…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial Activity of Some Folk Medicinal Plants Used in Rajasthan Against Selected Pathogenic Microorganisms

Verma

Kumar

2017

Int J Curr Pharm Sci

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Objective: To investigate the antibacterial efficacy of methanol extracts of leaves and roots of B. diffusa, Eclipta alba, Phyllanthus niruri and Ricinus communis. Methods:The antimicrobial efficacy of methanol extracts of some medicinal plants was evaluated by agar well diffusion method against selected pathogenic bacterial strains. Gram+ve strains (S. aureus, B. subtilis) were tested and Gram-ve strains tested were (E. coli, S. typhii and K. pneumoniae). Antifungal activity against was tested.Results: B. diffusa and P. niruri leaf extract showed highest antibacterial activity against S. aureus and S. typhii. Leaf extract of P. niruri and R. communis showed highest antifungal activity against A. niger and C. albicans respectively Conclusion:The methanolic leaf extracts of B. diffusa and P. niruri were highly active against S. aureus and S. typhii.

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Activity guided isolation of antioxidants from the leaves of Ricinus communis L.

Cited by 68 publications

References 18 publications

Antioxidant Activity of Madhuraprabhava Drugs Delineated in Madhuraskandha of Charaka's Materia Medica

Antioxidant Activity of Madhuraprabhava Drugs Delineated in Madhuraskandha of Charaka's Materia Medica

Antioxidant activity and low cytotoxicity of extracts and isolated compounds fromAraucaria angustifoliadead bark

Antimicrobial Activity of Some Folk Medicinal Plants Used in Rajasthan Against Selected Pathogenic Microorganisms

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