Activity Evaluation and Toxicological Profile of New Potential Metal Protein Attenuating Compounds in Biological Models of Alzheimer S Disease

Development of Electro-Analytical Methods Using Sensors Modified With Nanomaterials for Determination of Primaquine, Inhhq, Thiomersal and Creatinine

“…5.1) has demonstrated in vitro metal protein attenuating activity in recent works [101][60] as it was capable of blocking the interactions of Zn 2+ and Cu 2+ with the Ab protein. In vivo studies have showed no lethality in acute exposure at high doses, up to 300 mg per kg of body weight in healthy rats [101], and suggested that an innocuous dose of 1mg per kg of body weight that was intraperitoneally injected in physiologic solution containing 10% dimethyl sulfoxide is adequate to prevent memory loss in an Alzheimer's disease mouse model [102]. In addition to the 8hydroxyquinoline group, INHHQ also contains an isoniazid group, resulting in a ligand capable of coordinating metal ions of biological importance through different donor atoms including nitrogen and oxygen [103].…”