Activity diversity structure-activity relationship of polysaccharides from lotus root varieties

Yi, Yang; Lamikanra, Olusola; Sun, Jie; Wang, Limei; Min, Ting; Wang, Hongxun

doi:10.1016/j.carbpol.2017.11.090

Cited by 53 publications

(29 citation statements)

References 35 publications

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“…In particular, Wikiera et al [ 44 ] found a close relationship between the binding of the DPPH radical and the content of phenolics, fucose and proteins (R 2 = 0.94, 0.80 and 0.80, respectively) in apple pectins. In [ 45 ] and [ 46 ], it was shown that antioxidant activity towards the DPPH radical was positively related to the content of arabinose and negatively related to the content of uronic acids (galacturonic and glucuronic) in polysaccharides of various structures. However, these authors did not include phenolics in their analysis, which explains the lower efficiency of their regression models (R 2 = 0.28–0.46 [ 45 ], 0.70 [ 47 ], 0.81 [ 46 ], compared with the present study (R 2 = 0.90).…”

Section: Resultsmentioning

confidence: 99%

“…In [ 45 ] and [ 46 ], it was shown that antioxidant activity towards the DPPH radical was positively related to the content of arabinose and negatively related to the content of uronic acids (galacturonic and glucuronic) in polysaccharides of various structures. However, these authors did not include phenolics in their analysis, which explains the lower efficiency of their regression models (R 2 = 0.28–0.46 [ 45 ], 0.70 [ 47 ], 0.81 [ 46 ], compared with the present study (R 2 = 0.90). The content of phenolics in fireweed pectin was determined to be more strongly associated with the content of glucose (R 2 = 0.76, p = 0.000) and xylose (R 2 = 0.57, p = 0.004) than arabinose and galactose (R 2 = 0.19 and 0.12, p > 0.1).…”

Section: Resultsmentioning

confidence: 99%

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Isolation, Chemical Characterization and Antioxidant Activity of Pectic Polysaccharides of Fireweed (Epilobium angustifolium L.)

Popov¹,

Смирнов²,

Kvashninova³

et al. 2021

Molecules

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The aim of this study was to isolate pectins with antioxidant activity from the leaves of Epilobium angustifolium L. Two pectins, EA-4.0 and EA-0.8, with galacturonic acid contents of 88 and 91% were isolated from the leaves of E. angustifolium L. by the treatment of plant raw materials with aqueous hydrochloric acid at pH 4.0 and 0.8, respectively. EA-4.0 and EA-0.8 were found to scavenge the DPPH radical in a concentration-dependent manner at 17–133 μg/mL, whereas commercial apple pectin scavenged at 0.5–2 mg/mL. The antioxidant activity of EA-4.0 was the highest and exceeded the activity of EA-0.8 and a commercial apple pectin by 2 and 39 times (IC50—0.050, 0.109 and 1.961 mg/mL), respectively. Pectins EA-4.0 and EA-0.8 were found to possess superoxide radical scavenging activity, with IC50s equal to 0.27 and 0.97 mg/mL, respectively. Correlation analysis of the composition and activity of 32 polysaccharide fractions obtained by enzyme hydrolysis and anionic exchange chromatography revealed that the antioxidant capacity of fireweed pectins is mainly due to phenolics and is partially associated with xylogalacturonan chains. The data obtained demonstrate that pectic polysaccharides appeared to be bioactive components of fireweed leaves with high antioxidant activity, which depend on pH at their extraction.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Isolation, Chemical Characterization and Antioxidant Activity of Pectic Polysaccharides of Fireweed (Epilobium angustifolium L.)

Popov¹,

Смирнов²,

Kvashninova³

et al. 2021

Molecules

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“…The levels of galactose, rhamnose, arabinose, and galacturonic acid were maximum in JSP-1 compared to JSP-2. As per available findings that the antioxidant and the hypoglycemic activities of polysaccharides were linked with rhamnose, arabinose, and galacturonic acid, it makes a reasonable justification for the higher antioxidant and hypoglycemic activities of JSP-1 [28,29].…”

Section: Monosaccharide Composition and Molecular Weightmentioning

confidence: 80%

Novel Antioxidant and Hypoglycemic Water-Soluble Polysaccharides from Jasmine Tea

Tang

Sheng

et al. 2021

Foods

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There have been few studies dealing with chemical elucidation and pharmacological potentials of water-soluble polysaccharides from jasmine tea, limiting their use in functional foods. In this study, water-soluble polysaccharides (named as JSP) were extracted from Jasminum sambac (L.) Aiton tea and fractionated to afford two sub-fractions (JSP-1 and JSP-2). The main structural characteristics of novel JSP sub-fractions were determined by high performance gel permeation chromatography, ultra-performance liquid chromatography-tandem mass spectrometry, Fourier transform infrared, and nuclear magnetic resonance analysis. Physiologically, the abilities of JSP-1 and JSP-2 to reduce ferric ions, scavenge DPPH and hydroxyl radicals, as well as protect islet cells were confirmed in vitro. JSP-1 exhibited better antioxidant and hypoglycemic activities than JSP-2. The molecular weights of JSP-1 and JSP-2 were 18.4 kDa and 14.1 kDa, respectively. JSP-1 was made up of glucose, galactose, rhamnose, xylose, arabinose, and galacturonic acid with molar ratios 1.14:4.69:1.00:9.92:13.79:4.09, whereas JSP-2 with a triple helical structure was composed of galactose, rhamnose, xylose, arabinose, and galacturonic acid as 3.80:1.00:8.27:11.85:5.05 of molar ratios. JSP-1 contains →1)-α-Galƒ-(3→, →1)-α-Galƒ-(2→, →1)-α-Araƒ-(5→, →1)-α-Araƒ-(3→, →1)-α-Araƒ-(3,5→, →1)-β-Xylp-(2→ and →1)-β-Xylp-(3→ residues in the backbone. These results open up new pharmacological prospects for the water-soluble polysaccharides extracted from jasmine tea.

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“… 26 Fingerprint-based multivariate statistical analysis of LRPs has been applied to explore the crucial characteristics contributing to their antioxidant, cancer cell growth inhibitory and immunostimulatory activities, providing new insights in the structure–activity relationship of polysaccharides. 27 Those characteristics are probably regarded as a guarantee of effective activities.…”

Section: Resultsmentioning

confidence: 99%

Fingerprint profiling of polysaccharides from different parts of lotus root varieties

Wang

Sun

et al. 2018

RSC Adv.

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Activity diversity structure-activity relationship of polysaccharides from lotus root varieties

Cited by 53 publications

References 35 publications

Isolation, Chemical Characterization and Antioxidant Activity of Pectic Polysaccharides of Fireweed (Epilobium angustifolium L.)

Isolation, Chemical Characterization and Antioxidant Activity of Pectic Polysaccharides of Fireweed (Epilobium angustifolium L.)

Novel Antioxidant and Hypoglycemic Water-Soluble Polysaccharides from Jasmine Tea

Fingerprint profiling of polysaccharides from different parts of lotus root varieties

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