Activity-Dependent Plasticity of Spike Pauses in Cerebellar Purkinje Cells

Grasselli, Giorgio; He, Qionger; Wan, Vivian; Adelman, John P.; Ohtsuki, Gen; Hansel, Christian

doi:10.1016/j.celrep.2016.02.054

Cited by 62 publications

(79 citation statements)

References 35 publications

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“…On the other hand, intrinsic plasticity may affect neuronal spike output independent from synaptic plasticity. For example, SK channel-dependent intrinsic plasticity reduces the duration of spike pauses in Purkinje cells and may thus alter the spike output of the cerebellar cortex without any synaptic involvement in the expression phase of this plasticity mechanism (Grasselli et al, 2016; Fig. 3).…”

Section: Intrinsic Plasticity: Cellular Mechanisms and Relevance To Lmentioning

confidence: 99%

“…On a final note, we would like to point out that changes in intrinsic excitability can also be part of the memory trace without any involvement of synapses (other than in the induction phase). We have recently shown that intrinsic plasticity can alter the duration of spike pauses in Purkinje cells, thus changing the spike burst - pause sequence that is characteristic for the output from cerebellar cortex (Grasselli et al, 2016; Fig. 3).…”

Section: The Synapse Versus the Neuron As The Critical Site In Memorymentioning

confidence: 99%

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Toward a Neurocentric View of Learning

Titley

Brunel

Hansel

2017

Neuron

Self Cite

184

177

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Synaptic plasticity (e.g. long-term potentiation; LTP) is considered as the cellular correlate of learning. Recent optogenetic studies on memory engram formation assign a critical role in learning to suprathreshold activation of neurons and their integration into active engrams (‘engram cells’). Here we review evidence that ensemble integration may result from LTP, but also from cell-autonomous changes in membrane excitability. We propose that synaptic plasticity determines synaptic connectivity maps, while intrinsic plasticity – possibly separated in time – amplifies neuronal responsiveness and acutely drives engram integration. Our proposal marks a move away from an exclusively synaptocentric toward a non-exclusive, neurocentric view of learning.

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Section: Intrinsic Plasticity: Cellular Mechanisms and Relevance To Lmentioning

confidence: 99%

Section: The Synapse Versus the Neuron As The Critical Site In Memorymentioning

confidence: 99%

Toward a Neurocentric View of Learning

Titley

Brunel

Hansel

2017

Neuron

Self Cite

184

177

View full text Add to dashboard Cite

show abstract

“…As SK2 channels have been shown to underlie the medium AHP in Purkinje cells (Kakizawa et al, 2007;Grasselli et al, 2016), we looked at the AHP following a burst of 10 parallel fiber stimuli at 100 Hz. Figure 3 shows example traces for Purkinje cells from a pseudoconditioned ( Figure 3A) and a conditioned animal ( Figure 3B) following a burst of parallel fiber stimulation.…”

Section: Decreased Amplitudes Of Ahps Following Parallel Fiber Burstsmentioning

confidence: 99%

Intrinsic Excitability Increase in Cerebellar Purkinje Cells Following Delay Eyeblink Conditioning in Mice

Titley

Watkins

Lin

et al. 2018

Preprint

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Cerebellar learning is canonically thought to rely on synaptic plasticity, particularly at synaptic inputs to Purkinje cells. Recently, however, other complementary mechanisms have been identified. Intrinsic plasticity is one such mechanism, and depends in part on the down-regulation of calcium-dependent SK-type K channels, which is associated with an increase in neuronal excitability. In the hippocampus, SK-mediated intrinsic plasticity has been shown to play a role in trace eyeblink conditioning; however, it is not yet known how intrinsic plasticity contributes to a cerebellar learning task such as delay eyeblink conditioning. Whole cell recordings were obtained from acute cerebellar slices from mice ~48 hours after learning a delay eyeblink conditioning task. Over a period of repeated training sessions mice received either distinctly paired trials of a tone co-terminating with a periorbital shock (conditioned mice) or trials in which these stimuli were presented in an unpaired manner (pseudoconditioned mice). Conditioned mice show a significantly reduced afterhyperpolarization (AHP) following trains of parallel fiber stimuli.Moreover, we find that SK-dependent intrinsic plasticity is occluded in conditioned, but not pseudoconditioned mice. These findings show that excitability is enhanced in Purkinje cells after delay eyeblink conditioning and point toward a downregulation of SK channels as a potential underlying mechanism.

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“…More recent evidence has suggested that post-complex spike pauses are regulated in an activity-dependent manner [92], which could affect the rate of CN plasticity. These findings support the idea that post-complex spike pauses train circuit changes in CN by selectively enhancing plasticity at MF to CN synapses.…”

Section: Contribution Of Climbing Fibers To Cerebellar Cortex and Cermentioning

confidence: 99%

The Roles of the Olivocerebellar Pathway in Motor Learning and Motor Control. A Consensus Paper

et al. 2016

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For many decades the predominant view in the cerebellar field has been that the olivocerebellar system's primary function is to induce plasticity in the cerebellar cortex, specifically, at the parallel fiber-Purkinje cell synapse. However, it has also long been proposed that the olivocerebellar system participates directly in motor control by helping to shape ongoing motor commands being issued by the cerebellum. Evidence consistent with both hypotheses exists; however, they are often investigated as mutually exclusive alternatives. In contrast, here we take the perspective that the olivocerebellar system can contribute to both the motor learning and motor control functions of the cerebellum, and might also play a role in development. We then consider the potential problems and benefits of its having multiple functions. Moreover, we discuss how its distinctive characteristics (e.g., low firing rates, synchronization, variable complex spike waveform) make it more or less suitable for one or the other of these functions, and why its having a dual role makes sense from an evolutionary perspective. We did not attempt to reach a consensus on the specific role(s) the olivocerebellar system plays in different types of movements, as that will ultimately be determined experimentally; however, collectively, the various contributions highlight the flexibility of the olivocerebellar system, and thereby suggest it has the potential to act in both the motor learning and motor control functions of the cerebellum.

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Activity-Dependent Plasticity of Spike Pauses in Cerebellar Purkinje Cells

Cited by 62 publications

References 35 publications

Toward a Neurocentric View of Learning

Toward a Neurocentric View of Learning

Intrinsic Excitability Increase in Cerebellar Purkinje Cells Following Delay Eyeblink Conditioning in Mice

The Roles of the Olivocerebellar Pathway in Motor Learning and Motor Control. A Consensus Paper

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