Activity-dependent neuroprotector homeobox protein: A candidate protein identified in serum as diagnostic biomarker for Alzheimer's disease

Specific protein biomarker patterns for Alzheimer’s disease: improved diagnostics in progress

“…Another work collected human serum specimens from 45 early-stage AD patients (mean age 77.2 years) and 20 normal individuals (mean age 72.3 years) identified by similar technologies 5 up-regulated proteins, namely, actin, apolipoprotein A-IV (Apo A-IV), inter-alpha-trypsin inhibitor heavy chain H4 (ITIH4), alpha-1-antitrypsin (AAT), and antithrombin-III (AT-III); and one down-regulated protein, activity-dependent neuroprotecting protein (ADNP) in early AD patients [18]. Interestingly, not the same proteins were picked up as major blood players in the two studies cited above, suggesting potential impact for the disease status, non-demented elderly exhibiting amyloid plaques vs. early AD.…”

“…Furthermore, the possibility of personalized stratification is also tantalizing. Regardless, looking at ADNP in two geographically/ethically different groups, in one paper from Taiwan [18] and in one paper including a collaborative work between the USA and Israel [27], correlated serum ADNP levels with cognition/AD. Current and future studies are also looking at blood exosomes [30].…”

Theory and Practice of UHPLC and UHPLC–MS

“…Two types of efficient capillary zwitterionic organic-silica hybrid monolithic columns were synthesized in a single-step thermally induced polymerization, by using [2-(methacryloyloxy)-ethyl] dimethyl-(3-sulfopropyl)ammonium hydroxide or [2-(methacryloyloxy)-ethyl] phosphorylcholine as the organic monomers and [3-(methacryloxy)-propyl]trimethoxysilane. The columns were suitable for HILIC separations of various low-molecular-weight neutral, basic, and acidic analytes, as well as small peptides in tryptic digests (Lin et al, 2012).…”

Tau Diagnostics and Clinical Studies

“…A proteomic approach identified the tauinteracting activity-dependent neuroprotective protein (ADNP) (Oz et al 2012;Schirer et al 2014;IvashkoPachima et al 2017), as the only protein down-regulated in serum samples from early AD patients (Yang et al 2012). These studies were corroborated showing that blood borne expression of ADNP is correlated with premorbid intelligence, AD pathology, and clinical stage.…”