Activity-dependent neuroprotective protein (ADNP) expression level is correlated with the expression of the sister protein ADNP2: Deregulation in schizophrenia

Dresner, Efrat; Agam, Galila; Gozes, Illana

doi:10.1016/j.euroneuro.2010.06.004

Cited by 64 publications

(60 citation statements)

References 32 publications

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“…For further reference on ADNP and NAP, please refer to our previous reviews with some examples cited here, [18,[45][46][47][48][49][50] and to our recent studies extending ADNP biology and NAP efficacy to other neurotrophic and neurodegenerative disease models [50][51][52][53][54][55][56][57][58][59][60].…”

Section: Introductionmentioning

confidence: 99%

Protection Against Tauopathy by the Drug Candidates NAP (Davunetide) and D-SAL: Biochemical, Cellular and Behavioral Aspects

Shiryaev¹,

Pikman²,

Giladi³

et al. 2011

CPD

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Activity-dependent neuroprotective protein (ADNP) is essential for brain formation and partial deficiency in ADNP results in cognitive deficits coupled with tauopathy and neuronal cell death. Our previous results indicated that a peptide snippet from ADNP, NAPVSIPQ (NAP, generic name, davunetide) can restore in part ADNP deficiencies. NAP interacts with tubulin and this interaction is displaced by the NAP related peptide that is derived from activity-dependent neurotrophic factor (ADNF), SALLRSIPA (SAL) and its all D-amino acid peptide derivative (D-SAL, also known as AL-309). Both NAP and D-SAL were shown to protect neurons against amyloid beta toxicity however the mechanism of protection is still under investigation. In addition, NAP protects against tau hyperphosphorylation associated with ADNP deficiency, in vivo. To investigate whether the mechanism of in vitro neuroprotection relates to the in vivo protection against tauopathy and to draw potential additional parallelism between NAP and D-SAL, we asked if: 1]NAP and D-SAL protect against amyloid beta related tau hyperphosphorylation in vitro; and 2] D-SAL protects against haploinsufficiency in ADNP, inhibiting tauopathy in vivo. Assessment of NAP and D-SAL neuroprotection in primary cortical neuro-glial cultures treated with amyloid beta showed that both peptides reduced toxin-related neuronal damage and protected against tau hyperphosphorylation. In vivo, chronic D-SAL administration protected against tau hyperphosphorylation associated with ADNP deficiency (ADNP+/- mice), showing for the first time protection against deficits in odor discrimination and in social recognition. These studies associate neuroprotection in vivo and in vitro and provide a broad base for future drug development based on NAP and D-SAL against multiple neurodegenerative conditions.

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Section: Introductionmentioning

confidence: 99%

Protection Against Tauopathy by the Drug Candidates NAP (Davunetide) and D-SAL: Biochemical, Cellular and Behavioral Aspects

Shiryaev¹,

Pikman²,

Giladi³

et al. 2011

CPD

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“…3 days later, RNA was extracted, and mRNA levels of ADNP, ADNP2, band3, and ␤-globin were evaluated. RNA extraction and quantitative real time PCR were performed as described previously (supplemental material) (15). Primers (supplemental Table S2) were synthesized by Sigma Genosys.…”

Section: Fish Maintenance and Isolation Of Zebrafish Adnp And Adnp2mentioning

confidence: 99%

Novel Evolutionary-conserved Role for the Activity-dependent Neuroprotective Protein (ADNP) Family That Is Important for Erythropoiesis

Dresner¹,

Malishkevich²,

Arviv³

et al. 2012

Journal of Biological Chemistry

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Background: ADNP is vital for embryonic development. Is this function conserved for the homologous protein ADNP2? Results: Down-regulation/silencing of ADNP or ADNP2 in zebrafish embryos or mouse erythroleukemia cells inhibited erythroid maturation, with ADNP directly associating with the ␤-globin locus control region. Conclusion: ADNPs are novel molecular regulators of erythropoiesis. Significance: New regulators of globin synthesis are suggested.

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“…In the ADNP-deficient model (Vulih-Shultzman et al 2007) as well as in models of Alzheimer's disease (Matsuoka et al 2007;Matsuoka et al 2008) and frontotemporal dementia (Shiryaev et al 2009), we showed that intranasal administration of NAP ameliorated spatial memory impairments and inhibited tau-related pathology. It is interesting to note that ADNP and its related protein ADNP2, proteins that are important for cellular viability (Kushnir et al 2008) are both expressed in the human hippocampus (Bassan et al 1999;Dresner et al 2010;Zamostiano et al 2001) that is associated with short-term memory and Alzheimer's disease pathology. Importantly, our most recent studies show that ADNP/ADNP2 expression is deregulated in the hippocampus of schizophrenia patients (Dresner et al 2010).…”

Section: Editorial: From the Desk Of The Editor-in-chiefmentioning

confidence: 99%

“…It is interesting to note that ADNP and its related protein ADNP2, proteins that are important for cellular viability (Kushnir et al 2008) are both expressed in the human hippocampus (Bassan et al 1999;Dresner et al 2010;Zamostiano et al 2001) that is associated with short-term memory and Alzheimer's disease pathology. Importantly, our most recent studies show that ADNP/ADNP2 expression is deregulated in the hippocampus of schizophrenia patients (Dresner et al 2010). Furthermore, intranasal NAP treatment protects against learning and memory impairments in a mouse model associated with cytoskeletal dysfunctions that are related to schizophrenia (Merenlender-Wagner et al 2010).…”

Section: Editorial: From the Desk Of The Editor-in-chiefmentioning

confidence: 99%

Activity-dependent neuroprotective protein (ADNP) expression level is correlated with the expression of the sister protein ADNP2: Deregulation in schizophrenia

Cited by 64 publications

References 32 publications

Protection Against Tauopathy by the Drug Candidates NAP (Davunetide) and D-SAL: Biochemical, Cellular and Behavioral Aspects

Protection Against Tauopathy by the Drug Candidates NAP (Davunetide) and D-SAL: Biochemical, Cellular and Behavioral Aspects

Novel Evolutionary-conserved Role for the Activity-dependent Neuroprotective Protein (ADNP) Family That Is Important for Erythropoiesis

VIP–PACAP 2010: My Own Perspective on Modulation of Cognitive and Emotional Behavior

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