2014
DOI: 10.1093/chemse/bju015
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Activity-Dependent Genes in Mouse Olfactory Sensory Neurons

Abstract: Activity-dependent survival of olfactory sensory neurons (OSNs) may allow animals to tune their olfactory systems to match their odor environment. Activity-dependent genes should play important roles in this process, motivating experiments to identify them. Both unilateral naris occlusion of mice for 6 days and genetic silencing of OSNs decreased S100A5, Lrrc3b, Kirrel2, Slc17a6, Rasgrp4, Pcp4l1, Plcxd3, and Kcnn2 while increasing Kirrel3. Naris occlusion also decreased Eml5, Ptprn, and Nphs1. OSN number was u… Show more

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Cited by 30 publications
(40 citation statements)
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“…Lastly, Figure 4 presents the p -values of an experiment by Fischl et al [ 3 ] where paired t -tests were used to compare dependent samples. From the histogram, it appears as though something has gone wrong: there is an abundance not of low p -values but of p -values near 0.3.…”
Section: Introductionmentioning
confidence: 99%
“…Lastly, Figure 4 presents the p -values of an experiment by Fischl et al [ 3 ] where paired t -tests were used to compare dependent samples. From the histogram, it appears as though something has gone wrong: there is an abundance not of low p -values but of p -values near 0.3.…”
Section: Introductionmentioning
confidence: 99%
“…With a binwidth of 0.05, this amounts to checking 20 bins, and therefore using a corrected significance threshold of 0.05/20=0.0025, or equivalently, a frequency threshold of F .9975 (m, b). For the data from the study by Fischl et al [3] in Figure 4, m = 23, 332 and b = 0.05, so the frequency threshold is 1261.…”
Section: Quality Controlmentioning
confidence: 98%
“…The other issue is that permutation approaches cannot be applied to very small samples. For example, we cannot use a permutation approach to investigate the Fischl et al [3] data from Figure 6, which involves a one-sample t-test with only 3 pairs of subjects. Although the idea can be extended to paired data (by randomly assigning signs to the differences rather than permuting rows), in this case there are only Preprints (www.preprints.org) | NOT PEER-REVIEWED | Posted: 5 August 2018 doi:10.20944/preprints201808.0091.v1…”
Section: Incorrect Distributional Assumptionsmentioning
confidence: 99%
“…S100A5 is expressed primarily in the olfactory bulb and olfactory sensory neurons (OSNs). Its expression is dramatically upregulated by odor stimulation [ 8 10 ]. It has been proposed that S100A5 is actively involved in olfactory signalling due to its expression profile [ 9 ].…”
Section: Introductionmentioning
confidence: 99%