Activity changes of glyoxalase system enzymes and glutathione-S-transferase in the bivalve mollusc Scapharca inaequivalvis exposed to the organophosphate chlorpyrifos

Antognelli, Cinzia; Baldracchini, Francesca; Andrea, Piazzoli; Frosini, Roberta; Talesa, Vincenzo; Giovannini, Elvio

doi:10.1016/j.pestbp.2006.01.007

Cited by 29 publications

(8 citation statements)

References 27 publications

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“…The GST activity was usually increased because of metabolism with xenobiotic pollutants. Similar results were present in many present studies, confirming that the induction of GST activity is closely related to the exposure time and concentrations (Antognelli et al, 2006). In the current assay, the GST activity increased markedly, except for the 5 mg L À 1 treatment group on day 21.…”

Section: Oxidative Stress and Ros Levelssupporting

confidence: 92%

Toxic effects of nitenpyram on antioxidant enzyme system and DNA in zebrafish (Danio rerio) livers

Yan

Wang

Zhu

et al. 2015

Ecotoxicology and Environmental Safety

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Section: Oxidative Stress and Ros Levelssupporting

confidence: 92%

Toxic effects of nitenpyram on antioxidant enzyme system and DNA in zebrafish (Danio rerio) livers

Yan

Wang

Zhu

et al. 2015

Ecotoxicology and Environmental Safety

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“…The GST activity was expected to reflect the exposure to chemical contaminants present in the environment. Most studies report a raised GST activity in response to environmental or laboratory exposure to contaminants (Antognelli et al, 2006; Camargo and Martinez 2006; Richardson et al, 2008). On the contrary, in this study, a significant decrease was observed for mussels transplanted to the most contaminated site.…”

Section: Discussionmentioning

confidence: 99%

Lessons from a transplantation of zebra mussels into a small urban river: An integrated ecotoxicological assessment

Bourgeault¹,

Gourlay-Francé²,

Vincent-Hubert³

et al. 2010

Environmental Toxicology

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It is often difficult to evaluate the level of contamination in small urban rivers because pollution is mainly diffuse, with low levels of numerous substances. The use of a coupled approach using both chemical and biological measurements may provide an integrated evaluation of the impact of micro-pollution on the river. Zebra mussels were transplanted along a metal and organic pollution gradient in spring 2008. For two months, mussels and water samples were collected from two sites every two weeks and analyzed for metal and PAH content as well as water physicochemical parameters. Diffusive gradients in thin film (DGT) were also used to assess levels of labile metals. Exposure of mussels to contaminants and potential impact were evaluated using physiological indices and various biomarkers including condition index (CI), defense mechanisms (glutathione-S-transferase: GST), digestive enzymes (amylase and cellulase) and genotoxicity (micronucleus test: MN and comet assay: CA). For most contaminants, the water contamination was significantly higher downstream. Bioaccumulation in zebra mussels was related to water contamination in the framework of the biodynamic model, which allowed us to take into account the biological dilution that was caused by the growth of soft tissue downstream. Thus, metal influxes were on average two times higher downstream than upstream in particular for Zn, Cr, Cu and Cd. Significant differences in condition index were observed (final CI was 0.42 ± 0.03 downstream and 0.31 ± 0.03 upstream) reflecting a better food availability downstream. Moreover a significant decrease of GST activity and digestive enzymes activity in the cristalline style was observed downstream. Interpreting this decrease requires considering not only micro-pollution but also the trophic status related to the water's physicochemistry. The MN test and the CA on gill cells highlighted genotoxicity in mussels transplanted downstream compared to upstream.

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“…In addition to these effects, CPF can also trigger a response from the detoxifying and antioxidant enzymes glutathione transferases (GST) in animals. As a consequence, GST activity generally increases upon exposure to contaminants in order to eliminate the xenobiotics (Hayes et al, 2005) and has been widely used to measure xenobiotics toxicity in aquatic organisms (Antognelli et al, 2006;Wang et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Effects of chlorpyrifos on cholinesterase activity and stress markers in the tropical reef fish Acanthochromis polyacanthus

Botté

Jerry

King

et al. 2012

Marine Pollution Bulletin

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Activity changes of glyoxalase system enzymes and glutathione-S-transferase in the bivalve mollusc Scapharca inaequivalvis exposed to the organophosphate chlorpyrifos

Cited by 29 publications

References 27 publications

Toxic effects of nitenpyram on antioxidant enzyme system and DNA in zebrafish (Danio rerio) livers

Toxic effects of nitenpyram on antioxidant enzyme system and DNA in zebrafish (Danio rerio) livers

Lessons from a transplantation of zebra mussels into a small urban river: An integrated ecotoxicological assessment

Effects of chlorpyrifos on cholinesterase activity and stress markers in the tropical reef fish Acanthochromis polyacanthus

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