Activity changes during a conditioned aversive stimulus in rats with septal lesions

Mattingly, Bruce A.; Osborne, Francis H.; Gotsick, James E.

doi:10.1016/0031-9384(79)90019-2

Cited by 6 publications

(1 citation statement)

References 15 publications

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“…Along similar lines, the present study demonstrates a reduction in postshock freezing after MS lesions. This is not only consistent with earlier reports of the effects of septal lesions (Duncan, 1971; Mattingley, Osborne, & Gotsick, 1979; Trafton, 1967; but see also Brady & Nauta, 1953), but also resembles the reduction in postshock freezing seen after ventral hippocampal lesions using a similar testing procedure in this laboratory (Bannerman, Grubb, et al, 2002). As in this recent ventral hippocampal lesion study using an unsignaled shock delivery, although there was a reduction in postshock freezing during acquisition, there was no effect of either lesion during the retention test conducted 24 hr later.…”

Section: Discussionsupporting

confidence: 91%

Medial Septal Lesions Mimic Effects of Both Selective Dorsal and Ventral Hippocampal Lesions.

Bannerman¹,

Matthews²,

Deacon³

et al. 2004

Behavioral Neuroscience

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Electrolytic medial septal (MS) lesions, which depleted acetylcholinesterase staining in both dorsal and ventral hippocampus, produced a constellation of behaviors, combining aspects of both selective dorsal and ventral hippocampal lesion effects. MS lesions impaired spatial working memory on the T maze, thus resembling the effects of dorsal hippocampal lesions. In addition, MS lesions reduced anxiety during successive alleys (a modified form of the elevated plus-maze), social interaction, and hyponeophagia tests. MS lesions also reduced postshock freezing. These effects more closely resemble those of ventral hippocampal lesions. Therefore, the effects of electrolytic MS lesions derive from the resulting combined deafferentation of dorsal and ventral hippocampal regions, suggesting that previously reported effects of cytotoxic dorsal hippocampal lesions are unlikely to be due to a demyelination of fibers of passage coursing through the septal pole.

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