Activity based proteome profiling of serum serine hydrolases: application in pediatric abusive head trauma
Estelle Maret,
Kim Wiskott,
Tobias Shipley
et al.
Abstract:Purpose: Traumatic brain injury (TBI), including pediatric abusive head trauma (AHT), is the leading cause of death and disability in children and young adults worldwide. The current understanding of trauma-induced molecular changes in the brain of human subjects with intracranial haemorrhage (ICH) remains inadequate and requires further investigation to improve the outcome and management of TBI in the clinic. Calcium-mediated damage at the site of brain injury has been shown to activate several catalytic enzy… Show more
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