Activity Anti-Inflammatory and in silico Study of New Thiazolidinedione Derivatives

Anti-inflammatory and ulcerogenic activities of thiazolidine-4-ones in rats

“…In-vitro and in-vivo studies of PPARα agonists shown to have antiinflammatory activity through inhibition of expression of COX-2 genes induced by IL-1B and inhibition of production of interleukin IL-6, IL-8, PGs, cytokines resulting in reduction of cell influx, edema and thermal allodynia. 8 Considering the results of this study, we can conclude that thia-2 exhibited its anti-inflammatory activity in both acute and chronic models. Possible mechanism of action may be attributed to inhibition of release of histamine, serotonin, kinins and PGs in acute inflammation and also inhibition of chronic inflammatory responses like transudation, synthesis of collagen and mucopolysaccharides, proliferation of fibroblasts and formation of granuloma.…”

“…2,5,6 Thiazolidine derivatives (TZDs) are reported to alter various physiological processes such as inflammation, cell proliferation, angiogenesis and glucose metabolism with significant beneficial effects as anti-diabetic, antimicrobial, anti-chagasic, anti-HIV, anti-inflammatory, anti-atherosclerotic and anti-cancer agents. [7][8][9][10] TZDs are reported to act through Peroxisome proliferator-activated receptors (PPARs). The three types of PPARs namely PPARα, PPARδ and PPARγ, are encoded by different genes.…”

“…Some TZDs like rosiglitazone, pioglitazone and troglitazone were clinically and commercially available as antidiabetic drugs. 8 As discussed above, currently available NSAIDS are associated with unwanted side effects and have their own limitations. Hence there is a need for better anti-inflammatory drugs with fewer side effects.…”