2003
DOI: 10.1046/j.1365-2672.2003.01825.x
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Activity and mechanisms of action of selected biocidal agents on Gram-positive and -negative bacteria

Abstract: Aims: This study investigates the antimicrobial activity and mode of action of two natural products, eugenol and thymol, a commonly utilized biostatic agent, triclocarban (TCC), and two surfactants, didecyldimethylammonium chloride (DDDMAC) and C 10 -C 16 alkyldimethyl amine N-oxides (ADMAO). Methods and Results: Methods used included: determination of minimum inhibitory concentrations (MICs), lethal effect studies with suspension tests and the investigation of sub-MIC concentrations on growth of E. coli, Stap… Show more

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Cited by 432 publications
(272 citation statements)
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“…The significant antimicrobial activity of all these tested oils could be attributed to its major components. Indeed, the obtained results showed that Origanum compactum was dominated by phenols (thymol 19.21% et carvacrol 22.29%), which are known responsible of bactericidal activity of essential oils [32,33]. Thymol is also present at high concentration (42.01%) in Thymus vulgaris which would also explain the potent antimicrobial activity of this tested oil, as reported in an anterior study [34].…”
Section: Discussionsupporting
confidence: 59%
See 1 more Smart Citation
“…The significant antimicrobial activity of all these tested oils could be attributed to its major components. Indeed, the obtained results showed that Origanum compactum was dominated by phenols (thymol 19.21% et carvacrol 22.29%), which are known responsible of bactericidal activity of essential oils [32,33]. Thymol is also present at high concentration (42.01%) in Thymus vulgaris which would also explain the potent antimicrobial activity of this tested oil, as reported in an anterior study [34].…”
Section: Discussionsupporting
confidence: 59%
“…This may be probably related to chemical composition relative to each tested oils. Indeed, as we mentioned above, phenols, as major compound of Origanum compactum and Thymus vulgaris (but not found in Cymbopogon martinii), are well known responsible of bactericidal activity of essential oils [32,33].…”
Section: Discussionmentioning
confidence: 91%
“…This essential oil also presented strong to moderate inhibition (MIC and MBC 2.5mg mL -1 ) of the microorganisms used in the microdilution test, and was the second most active of the essential oils evaluated. Basil essential oil was characterized by the presence of linalool, 1,8-cineole and eugenol, which are active against both Grampositive and Gram-negative bacteria (WALSH et al, 2003;SOKOVIC et al, 2007). RUNYORO et al (2010) reported weak to moderate activity of that essential oil (MIC between 10.7 and 12.5mg mL -1 against S. aureus and between 3.14 and 4.25mg mL -1 against E. coli) for two evaluated basil samples that were poor in linalool and eugenol.…”
Section: Resultsmentioning
confidence: 99%
“…Increased membrane permeability is a major factor in the mechanism of antimicrobial action, where compounds may disrupt membranes and cause a loss of cellular integrity and eventual cell death [29]. Despite this information, the antimicrobial potential of the phenolic acids may be different against several microorganisms due to the number and position of substitutions in the benzene ring of phenolic acids and the saturated side-chain and length [30].…”
Section: Resultsmentioning
confidence: 99%