Activities of Tobramycin and Amikacin Against Gentamicin-Resistant Gram-Negative Bacilli

Houang, Elizabeth T.; Mckay-Ferguson, Edward

doi:10.1016/s0140-6736(76)90253-1

Cited by 5 publications

(1 citation statement)

References 10 publications

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“…Escherichia, Klebsiella, Enterobacter, Pseudomonas, and Serratia nqw account for well over half of all hospital-acquired infections (5). The aminoglycosides are among the most useful drugs currently available for treating serious infections due to these genera, but the problems associated with their use, that is, development of resistant strains (10,14,15,20) and potential toxicity (2,3,6,9,11,12,13,19,21), are well known.…”

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confidence: 99%

In Vitro Activity of Netilmicin Compared with Gentamicin, Tobramycin, Amikacin, and Kanamycin

Eickhoff¹,

Ehret²

1977

Antimicrob Agents Chemother

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The in vitro activity of netilmicin was compared with that of gentamicin, tobramycin, amikacin, and kanamycin against 636 strains of bacteria recently isolated from clinical sources. Gentamicin was the most active antibiotic, but netilmicin and tobramycin closely paralleled it. Netilmicin was generally fourto eightfold less active than gentamicin against Serratia and group A streptococci, and was twofold less active against Pseudomonas aeruginosa. When effects of inoculum size and concentration of divalent cations in the media were evaluated, netilmicin was shown to be similar to gentamicin in vitro. Minimum inhibitory concentrations for P. aeruginosa were increased as much as 18-fold when the Mg2+ and Ca2+ concentrations were increased to physiological levels in Mueller-Hinton broth.

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