Activities of Chromatin Remodeling Factors and Histone Chaperones and Their Effects in Root Apical Meristem Development

Kang, Huijia; Wu, Di; Fan, Tianyi; Zhu, Yan

doi:10.3390/ijms21030771

Cited by 14 publications

(11 citation statements)

References 99 publications

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“…Compounds 1−4 represent a new type of natural furancarboxylic acids featuring an unprecedented thiophene moiety. From a biogenetic point of view, aspertetronin A (10) 9,15 and cysteine 16 were assumed to be the biosynthetic precursor of compounds 1−4 (Scheme S1). Aspertetronin A (10) could undergo the thio conjugation with mercaptopyruvate to produce the thio intermediate (A), 16 which by a series of reactions including decarboxylation, cyclization, enolization, oxidation, and reduction would generate 1 with a 2,3disubsituted thiophene moiety.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

Antimicrobial Furancarboxylic Acids from a Penicillium sp.

Chang

Zhou

et al. 2020

J. Nat. Prod.

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Ten novel (1, 2, 3a, 3b, 4a, 4b, 5a, 5b, 6a, and 6b) furancarboxylic acids including four pairs of epimers (3a, 3b; 4a, 4b; 5a, 5b; 6a, 6b), together with seven known analogues (7a, 7b, 8a, 8b, 9a, 9b, and 10), were isolated from the fermentation of the soil-derived fungus Penicillium sp. sb62. Their structures were established on the basis of spectroscopic data analysis, and the absolute configurations were determined by time-dependent density functional theory electronic circular dichroism calculations, comparison of the specific optical rotation values, and modified Mosher's method. Compounds 1−4 represent the first class of natural furancarboxylic acids featuring a thiophene moiety. Compounds 1−7 showed antimicrobial inhibitory activities against Escherichia coli, Staphylococcus aureus, and Candida albicans with MIC values ranging from 0.9 to 7.0 μg/mL, from 1.7 to 3.5 μg/mL, and from 3.3 to 7.0 μg/mL, respectively.

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Section: ■ Results and Discussionmentioning

confidence: 99%

Antimicrobial Furancarboxylic Acids from a Penicillium sp.

Chang

Zhou

et al. 2020

J. Nat. Prod.

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“…Histone modification could favor chromatin "opening," thereby giving ways to a selective portion of DNA, which in turn recruit RNA polymerase II. Various histone modifications have been correlated to chromatin activation [149,151,160,161].…”

Section: Chromatin Remodeling In Cancermentioning

confidence: 99%

Reviewing cancer’s biology: an eclectic approach

Karidio

Şanlıer

2021

J Egypt Natl Canc Inst

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Background Cancer refers to a group of some of the worldwide most diagnosed and deadliest pathophysiological conditions that conquered researchers’ attention for decades and yet begs for more questions for a full comprehension of its complex cellular and molecular pathology. Main body The disease conditions are commonly characterized by unrestricted cell proliferation and dysfunctional replicative senescence pathways. In fact, the cell cycle operates under the rigorous control of complex signaling pathways involving cyclins and cyclin-dependent kinases assumed to be specific to each phase of the cycle. At each of these checkpoints, the cell is checked essentially for its DNA integrity. Genetic defects observed in these molecules (i.e., cyclins, cyclin-dependent kinases) are common features of cancer cells. Nevertheless, each cancer is different concerning its molecular and cellular etiology. These could range from the genetic defects mechanisms and/or the environmental conditions favoring epigenetically harbored homeostasis driving tumorigenesis alongside with the intratumoral heterogeneity with respect to the model that the tumor follows. Conclusions This review is not meant to be an exhaustive interpretation of carcinogenesis but to summarize some basic features of the molecular etiology of cancer and the intratumoral heterogeneity models that eventually bolster anticancer drug resistance for a more efficient design of drug targeting the pitfalls of the models.

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“…Chromatin remodeling results from the action of ATP-dependent complexes that change the association of DNA with core histones and from modifications of histone proteins, affecting the availability of DNA ( Kang et al 2020 ). The remodeling complexes change the structure of chromatin by repositioning, evicting or restructuring the nucleosome.…”

Section: Introductionmentioning

confidence: 99%

“…Chromatin remodelers include several sub-families of ATP-dependent enzymes. Each of these subfamilies has a specific composition of domains and subunits that are involved in histone exchange, assembly and repositioning of nucleosomes ( Kang et al 2020 ).…”

Section: Introductionmentioning

confidence: 99%

The epigenetic regulation of centromeres and telomeres in plants and animals

Achrem

Szućko

Kalinka

2020

CCG

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The centromere is a chromosomal region where the kinetochore is formed, which is the attachment point of spindle fibers. Thus, it is responsible for the correct chromosome segregation during cell division. Telomeres protect chromosome ends against enzymatic degradation and fusions, and localize chromosomes in the cell nucleus. For this reason, centromeres and telomeres are parts of each linear chromosome that are necessary for their proper functioning. More and more research results show that the identity and functions of these chromosomal regions are epigenetically determined. Telomeres and centromeres are both usually described as highly condensed heterochromatin regions. However, the epigenetic nature of centromeres and telomeres is unique, as epigenetic modifications characteristic of both eu- and heterochromatin have been found in these areas. This specificity allows for the proper functioning of both regions, thereby affecting chromosome homeostasis. This review focuses on demonstrating the role of epigenetic mechanisms in the functioning of centromeres and telomeres in plants and animals.

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Activities of Chromatin Remodeling Factors and Histone Chaperones and Their Effects in Root Apical Meristem Development

Cited by 14 publications

References 99 publications

Antimicrobial Furancarboxylic Acids from a Penicillium sp.

Antimicrobial Furancarboxylic Acids from a Penicillium sp.

Reviewing cancer’s biology: an eclectic approach

The epigenetic regulation of centromeres and telomeres in plants and animals

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