Activities of catabolic pathways and alkaloid biogenesis during submerged cultivation ofClaviceps sp. SD-58

Desai, J. D.; Desai, Anjana J.; Shah, Shruti

doi:10.1007/bf02877124

Cited by 6 publications

(5 citation statements)

References 15 publications

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“…Changes in NT-proBNP levels were described in prior studies of sacubitril/valsartan but in different patient populations. [5][6][7][8] The PARADIGM-HF study enrolled ambulatory patients with chronic HFrEF and patients with ADHF were excluded. 9,10 Patients randomized to receive sacubitril/valsartan vs enalapril had a greater reduction in NT-proBNP levels, and 48% vs 26% of patients had a reduction of more than 30% from baseline to 1 month after randomization.…”

Section: Discussionmentioning

confidence: 99%

Initiation of Angiotensin-Neprilysin Inhibition After Acute Decompensated Heart Failure

et al. 2020

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IMPORTANCE In PIONEER-HF, among stabilized patients with acute decompensated heart failure (ADHF), the in-hospital initiation of sacubitril/valsartan was well tolerated and led to improved outcomes compared with enalapril. However, there are limited data comparing the strategies of in-hospital vs postdischarge initiation of sacubitril/valsartan. OBJECTIVE To describe changes in N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels in patients recently hospitalized for ADHF and switching from taking enalapril to taking sacubitril/valsartan after discharge and compare clinical outcomes for patients randomized to receive in-hospital initiation of sacubitril/valsartan vs in-hospital initiation of enalapril who later switched to taking sacubitril/valsartan during an open-label extension phase. INTERVENTIONS Sacubitril/valsartan titrated to 97/103 mg twice daily. DESIGN, SETTING, AND PARTICIPANTS The PIONEER-HF trial was a multicenter, randomized, double-blind, active-controlled trial conducted at 129 US sites between May 2016 an May 2018 that compared the in-hospital initiation of sacubitril/valsartan vs enalapril (titrated to target dose, 10 mg twice daily) for 8 weeks among patients admitted for ADHF with reduced ejection fraction and hemodynamic stability. All patients were to continue in a 4-week, open-label study of sacubitril/valsartan; of 881 patients enrolled in PIONEER-HF, 832 (94%) continued in the open-label study. MAIN OUTCOMES AND MEASURES Changes in NT-proBNP levels from week 8 to 12 as well as the exploratory composite of heart failure rehospitalization or cardiovascular death from randomization through week 12. RESULTS Of 881 participants, 226 (27.7%) were women, 487 (58.5%) were white, 297 (35.7%) were black, 15 (1.8%) were Asian, and 73 (8.8%) were of Hispanic ethnicity; the mean (SD) age was 61 (14) years. For patients who continued to take sacubitril/valsartan, NT-proBNP levels declined −17.2% (95% CI, −3.2 to −29.1) from week 8 to 12. The NT-proBNP levels declined to a greater extent for those switching from taking enalapril to sacubitril/valsartan after the week 8 visit (−37.4%; 95% CI, −28.1 to −45.6; P < .001; comparing changes in 2 groups). Over the entire 12 weeks of follow-up, patients that began taking sacubitril/valsartan in the hospital had a lower hazard for the composite outcome compared with patients that initiated enalapril in the hospital and then had a delayed initiation of sacubitril/valsartan 8 weeks later (hazard ratio, 0.69; 95% CI 0.49-0.97). CONCLUSIONS AND RELEVANCE Switching patients' treatment from enalapril to sacubitril/valsartan at 8 weeks after randomization led to a further 37% reduction in NT-proBNP levels in patients with heart failure with reduced ejection fraction and a recent hospitalization for ADHF. TRIAL REGISTRATION ClinicalTrials.gov identifier: NCT02554890.

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Section: Discussionmentioning

confidence: 99%

Initiation of Angiotensin-Neprilysin Inhibition After Acute Decompensated Heart Failure

et al. 2020

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“…Senyawa tersebut terutama saponin dan tanin diharapkan dapat digunakan sebagai antelmintik. Saponin memiliki aktivitas antara lain sebagai hipolipidemik, menghambat pertumbuhan sel kanker, sebagai agen molluskisidal, antifungal, antiviral dan antibakterial (Taylor, 2004;Desai, 2009). Selain itu, Chapagain dan Wiesman (2005) menyatakan bahwa fraksi saponin merupakan agen larvisidal.…”

Section: Pendahuluanunclassified

“…Demikian pula pada konsentrasi 30%, 45%, dan 60% infusa rumput Kebar yang menunjukkan nilai R square model antara 0,737 -0,803 yang berarti bahwa variabel bebas lama perendaman dalam infusa rumput Kebar dapat menjelaskan Berdasarkan penelitian terdahulu, diketahui bahwa kandungan utama dari rumput Kebar, antara lain adalah tanin, flavonoid dan saponin (Mursyidi, 1989). Penelitian kali ini telah membuktikan efek antelmintik dari saponin yang terkandung dalam rumput kebar, sesuai dengan pendapat Desai, (2009), bahwa saponin mempunyai efek sebagai antelmintik.…”

Section: Hasil Dan Pembahasanunclassified

Test the Activity of the Juice and Infusion of Rumput Kebar (Biophytum petersianum Klotzsch) againts Ascaridia galli worms in Vitro

Widayati

Nurhayati

Baaka

2021

Jurnal Sain Veteriner

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Kebar grass contains active compounds that can be used as herbal ingredients in the treatment of diseases. This study was conducted to test the anthelmintic activity of grass kebar against worms Ascaridia galli in vitro. This study uses Kebar grass juice and infusion with a concentration of 15%, 30%, 45%, and 60%, and 4 repetitions. Each level of the experiment is placed in each cup containing 25 ml of solution and 5 worms. Worm mortality is recorded every 2 hours. The results showed that the juice and infusion of kebar grass were concentrations of 15%, 30%, 45%, 60% capable of killing worms with a mean time on the juice of Kebar grass respectively 9.5; 8; 7.5; 7 hours, and the average time for Kebar grass infusion is 9.5; 8.5; 8; 7.5 hours. The immersion time is a good variable to explain the variable of worm death at each concentration of treatment. There is an anthelmintic effect on grass juice and infuse kebar grass against worms Ascaridia galli in vitro. The duration of soaking and the concentration of juice and infusion of Kebar grass in this study had a significant effect on the mortality of worms. It was concluded that the juice and grass infuse kebar(Biophytum Petersianum Klotzsch) have anthelmintic effect against worms Ascaridia galli in vitro. Concentration Kebar grass juice and infuse kebar is increasing, then the shorter the time it takes to kill the worms Ascaridia galli in vitro.

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“…43 A significant reduction in blood glucose levels with some plant extracts might be due to their antioxidant properties or the hypoglycemic activity of phytochemical constituents. 44,45 An oral glucose tolerance test is a standard procedure that measures the clearance of an oral glucose load from the body or how quickly exogenous glucose can be cleared from the blood and is used in diagnosing diabetes mellitus. 46 It is also used to monitor temporal blood glucose fluctuations in response to an oral glucose challenge.…”

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confidence: 99%

“…Saponins in V. sinaiticum may have reduced blood glucose levels in diabetic mice by activating beta cells, suppressing glucose transfer from the stomach to the small intestine, and inhibiting glucose transport across the small intestine's brush boundary. 44 The presence of flavonoids, saponins, and tannins in V. sinaiticum may prevent the loss of beta cells via one or more of the aforementioned processes because the induction of diabetes mellitus involves the destruction of https://doi.org/10.2147/JEP.S437991…”

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confidence: 99%

Antidiabetic Activities of 80% Methanol Extract and Solvent Fractions of Verbascum Sinaiticum Benth (Scrophulariaceae) Leaves in Mice

Dereje,

Nardos,

Abdela

et al. 2023

JEP

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Background Because of the scarcity, high cost, and severe side effects of current medications, it is necessary to discover novel, safe, and affordable anti-diabetic drugs. The current study was conducted to evaluate the antidiabetic activities of Verbascum sinaiticum Benth leaves in mice. Methods Leaf coarse powder was extracted with 80% methanol and then fractionated with n-hexane, ethyl acetate, and distilled water. The glucose-lowering effects of V. sinaiticum at 100, 200, and 400mg/kg were then studied. Glibenclamide was used as a positive control at a dose of 5 mg/kg. For oral glucose tolerance tests and hypoglycemia tests, Tween 2% was used as a negative control, while citrate buffer was used as a negative control for antihyperglycemic investigations. The results from the study were evaluated using one-way ANOVA, and then Tukey’s post hoc multiple comparison test was performed. Results Blood glucose levels were significantly reduced by the V. sinaiticum 80% methanol extract at 400 mg/kg (p<0.05). The blood glucose levels were significantly lowered by the aqueous residue at 400 mg/kg (p<0.05) and the ethyl acetate fractions at 200 mg/kg (p<0.01) and 400 mg/kg (p<0.001); however, none of the fraction extracts resulted in hypoglycemic shock in healthy mice. Higher glucose tolerance was seen in orally glucose-loaded mice after exposure to 80% methanol extracts at 200 and 400 mg/kg (p<0.05), the aqueous residual fraction at 200 mg/kg (p<0.01), and the ethyl acetate fraction at 200 and 400 mg/kg (p<0.05). The ethyl acetate fraction at 200 and 400 mg/kg (p<0.01), the 80% methanol extract at 400 mg/kg (p<0.05) and the aqueous residue at 400 mg/kg (p 0.01) significantly lowered blood glucose levels in streptozotocin-induced diabetic mice. Conclusion The results of this study revealed that the 80% methanol extract and solvent fractions of V. sinaiticum Benth leaves are endowed with antidiabetic activity.

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Activities of catabolic pathways and alkaloid biogenesis during submerged cultivation ofClaviceps sp. SD-58

Cited by 6 publications

References 15 publications

Initiation of Angiotensin-Neprilysin Inhibition After Acute Decompensated Heart Failure

Initiation of Angiotensin-Neprilysin Inhibition After Acute Decompensated Heart Failure

Test the Activity of the Juice and Infusion of Rumput Kebar (Biophytum petersianum Klotzsch) againts Ascaridia galli worms in Vitro

Antidiabetic Activities of 80% Methanol Extract and Solvent Fractions of Verbascum Sinaiticum Benth (Scrophulariaceae) Leaves in Mice

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