Activities and toxicological significance of hepatic microsomal enzymes of the kestrel (Falco tinnunculus) and sparrowhawk (Accipiter nisus)

Walker, C.H.; Newton, Ian; Hallam, S.D.; Ronis, Martin J. J.

doi:10.1016/0742-8413(87)90099-5

Cited by 15 publications

(8 citation statements)

References 12 publications

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“…An inverse relationship between hepatic MFO activity and xeiiobiotic half-life has been demonstrated over a wide range of vertebrates 141. For example, low MFO activity in seabirds [17] and in the European sparrowhawlc (Accipiternisus) [18] is suggested io be a contributing factor to the accumulation of organochlorine pesticides in these species.…”

Section: Components Fiiiiction and Phylogeiietic Trendsmentioning

confidence: 99%

Use of Mixed-Function Oxygenases to Monitor Contaminant Exposure in Wildlife

Rattner¹,

Hoffman²,

Marn³

1989

Environ Toxicol Chem

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This overview examines the utility of mixed-function oxygenase (MFO) enzymes as a bioeffects monitor for wildlife (amphibians, reptiles, birds and mammals) i n view of their widespread use as indicators of contaminant exposure in aquatic invertebrates and fish. Phylogenetic trends i n MFO activity, toxicological implications of induction and the relationship between contaminant exposure and MFO activity are discussed. Field studies using avian embryos and hatchlings suggest that MFO induction has utility for documenting contaminant exposure; however, findings in adult birds and mammals are equivocal. Age, sex and season are sources of variation that require consideration when undertaking field trials. Further understanding of MFO inducibility among species and application of recently developed analytical techniques including quantification of specific cytochrome P-450 isozymes are warranted.

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Section: Components Fiiiiction and Phylogeiietic Trendsmentioning

confidence: 99%

Use of Mixed-Function Oxygenases to Monitor Contaminant Exposure in Wildlife

Rattner¹,

Hoffman²,

Marn³

1989

Environ Toxicol Chem

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“…Catalytic activity of MFOs has been studied to varying degrees in all vertebrate classes [4,5]. For example, low MFO activity in seabirds [17] and in the European sparrowhawlc (Accipiternisus) [18] is suggested io be a contributing factor to the accumulation of organochlorine pesticides in these species. Although these enzymes are distributed in many tissues, comparison of activity has utilized the liver, due to its relatively large size and its high MFO activity.…”

Section: Components Fiiiiction and Phylogeiietic Trendsmentioning

confidence: 99%

Use of mixed‐function oxygenases to monitor contaminant exposure in wildlife

Rattner

Hoffman

Marn

1989

Enviro Toxic and Chemistry

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This overview examines the utility of mixed‐function oxygenase (MFO) enzymes as a bio‐effects monitor for wildlife (amphibians, reptiles, birds and mammals) in view of their widespread use as indicators of contaminant exposure in aquatic invertebrates and fish. Phylogenetic trends in MFO activity, toxicological implications of induction and the relationship between contaminant exposure and MFO activity are discussed. Field studies using avian embryos and hatchlings suggest that MFO induction has utility for documenting contaminant exposure; however, findings in adult birds and mammals are equivocal. Age, sex and season are sources of variation that require consideration when undertaking field trials. Further understanding of MFO inducibility among species and application of recently developed analytical techniques including quantification of specific cytochrome P‐450 isozymes are warranted.

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“…. Such species require only a limited detoxifying function of this kind, because the potentially harmful xenobiotics in their food are limited in variety and/or quantity" [36]. On the other hand, species like the black-headed gull come into contact with a wide range of natural detoxifying systems.…”

Section: Discussionmentioning

confidence: 99%

Modulation of Mixed-Function Oxidase Activity in Black-Headed Gulls Living in Anthropic Environments: Biochemical Acclimatization or Adaptation?

Fossi¹,

Leonzio²,

Focardi³

et al. 1991

Environ Toxicol Chem

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This study was conducted to explore the role of the mixed-function oxidase (MFO) detoxication system in the "biochemical acclimatization" or adaptation of gulls to anthropic environments. In three different populations of black-headed gull (Larus ridibundus) feeding in a lagoon, in municipal and industrial landfills, MFO microsomal hepatic activities (aldrin epoxidase, 7-ethoxyresorufin-0-deethylase, NADPH-cytochrome c reductase, NADH-cytochrome c reductase, and NADH-ferricyanide reductase), microsomal a-naphthylacetate esterase activity, cytochrome P-450 forms, and chlorinated hydrocarbon residues were determined. Induction tests and in vitro comparative kinetics studies were completed between the different populations of gulls. The detoxicant activities of the MFO system were much higher in the landfill gulls, especially those of the industrial landfill, than in lagoon gulls. Lineweaver-Burk plots for aldrin epoxidase show an apparent K, four to five times lower in the gulls of the industrial landfill than in the other two populations.The origin of the potentiated detoxication activities in landfill gulls is investigated and the hypotheses of biochemical acclimatization and genetic adaptation are discussed.

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Activities and toxicological significance of hepatic microsomal enzymes of the kestrel (Falco tinnunculus) and sparrowhawk (Accipiter nisus)

Cited by 15 publications

References 12 publications

Use of Mixed-Function Oxygenases to Monitor Contaminant Exposure in Wildlife

Use of Mixed-Function Oxygenases to Monitor Contaminant Exposure in Wildlife

Use of mixed‐function oxygenases to monitor contaminant exposure in wildlife

Modulation of Mixed-Function Oxidase Activity in Black-Headed Gulls Living in Anthropic Environments: Biochemical Acclimatization or Adaptation?

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