Activities and Novel Applications of Secondary Metabolite Coumarins

Hussain, M. Iftikhar; Abbas, Syed Qamar; Reigosa, Manuel J.

doi:10.1590/s0100-83582018360100016

Cited by 25 publications

(19 citation statements)

References 73 publications

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“…Moreover, the cytotoxicity (of red blood cells) otherwise induced by amphotericin B was also prevented by the aqueous date extract [48]. Natural compounds such as phenolic acids, flavonoids, tannins, alkaloids, and steroids present in the plant extract are mostly responsible for herbicidal [49,50,51], antifungal [52], and antimicrobial activities [42]. The natural toxins might act individually as pharmaceutically active compounds or provide synergistic effect to exhibit the antimicrobial properties [42].…”

Section: Discussionmentioning

confidence: 99%

Phenolic Composition and Antimicrobial Activity of Different Emirati Date (Phoenix dactylifera L.) Pits: A Comparative Study

Hussain

Semreen

Shanableh

et al. 2019

Plants

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The biochemical composition, secondary metabolites (phenolic compounds, flavonoids) and antimicrobial potential of different varieties of Emirati date (Phoenix dactylifera L.) pits were investigated. Total phenolic acids (TPC) and total flavonoid contents (TFC) of the different date pits were measured using a Folin–Ciocalteau reagent. Different organic solvents [(n-hexane; H2O: EtOH (1:1); ethyl acetate; acetone: Water (1:1); and methanol: Chloroform (1:1)] were compared to evaluate the phytotoxicity of Ajwa, Fard, Khalas, Khodari, Abu Maan, Lulu, and Mabroom date pits. The antimicrobial activity of the date pit extracts were evaluated by means of agar-well diffusion assay on Staphylococcus aureus (ATCC 29123), Escherichia coli (ATCC 25922) and Candida albicans (ATCC 66027). Minimum inhibitory concentrations (MICs) were measured following clinical laboratory standardization institute (CLSI) protocol. The biochemical analyses of date pits indicate that TPC were ranged from 7.80 mg of equivalent gallic acid⁄100 g dry weight in Ajwa to 4.65 mg in Mabroom. The TFC were ranged between 1.6–4.54 mg of equivalent catechin⁄100 g dry weight. Ajwa pit extract showed good quality traits (higher protein, lower ash content, and intermediate dietary fiber). The results indicate that the ethyl acetate extract of Khalas and Khodari inhibited S. aureus with an inhibition zone diameter of 20 mm and MIC of 10 mg/mL. Abu Mann pit extract inhibited the S. aureus and also decreased the population of E. coli. The diameter of inhibition zone was 15, 16, and 18 mm after treatment with Ajwa extracts, while the MICs were 7.5 and 5 mg/mL. The MeOH: CFM extract of Abu Mann and Ajwa was more potent against E. coli bacteria than any other extract. This work demonstrates that the Emirati date pits extract has antimicrobial (antibacterial, antifungal) potential and can be used as phytotoxic natural compounds.

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Section: Discussionmentioning

confidence: 99%

Phenolic Composition and Antimicrobial Activity of Different Emirati Date (Phoenix dactylifera L.) Pits: A Comparative Study

Hussain

Semreen

Shanableh

et al. 2019

Plants

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“…Asteraceae are important for their recognized insecticidal activity described in the literature [36,37]. Alkalamides and coumarins showed insecticidal activity against Sitophylus oryzae and Rhyzopertha dominica [38], polyacetylenes and terpenes have proven insecticide and repellent activities against larvae and adults of A. aegypti [39][40][41].…”

Section: Plos Onementioning

confidence: 99%

Development of nano-emulsions based on Ayapana triplinervis essential oil for the control of Aedes aegypti larvae

et al. 2021

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Ayapana triplinervis is a plant species used in traditional medicine and in mystical-religious rituals by traditional communities in the Amazon. The aim of this study are to develop a nano-emulsion containing essential oil from A. triplinervis morphotypes, to evaluate larvicidal activity against Aedes aegypti and acute oral toxicity in Swiss albino mice (Mus musculus). The essential oils were extracted by steam dragging, identified by gas chromatography coupled to mass spectrometry, and nano-emulsions were prepared using the low energy method. Phytochemical analyses indicated the major compounds, expressed as area percentage, β-Caryophyllene (45.93%) and Thymohydroquinone Dimethyl Ether (32.93%) in morphotype A; and Thymohydroquinone Dimethyl Ether (84.53%) was found in morphotype B. Morphotype A essential oil nano-emulsion showed a particle size of 101.400 ± 0.971 nm (polydispersity index = 0.124 ± 0.009 and zeta potential = -19.300 ± 0.787 mV). Morphotype B essential oil nano-emulsion had a particle size of 104.567 ± 0.416 nm (polydispersity index = 0.168 ± 0.016 and zeta potential = -27.700 ± 1.307 mV). Histomorphological analyses showed the presence of inflammatory cells in the liver of animals treated with morphotype A essential oil nano-emulsion (MAEON) and morphotype B essential oil nano-emulsion (MBEON). Congestion and the presence of transudate with leukocyte infiltration in the lung of animals treated with MAEON were observed. The nano-emulsions containing essential oils of A. triplinervis morphotypes showed an effective nanobiotechnological product in the chemical control of A. aegypti larvae with minimal toxicological action for non-target mammals.

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“…Asteraceae are important for their recognized insecticidal activity described in the literature [34, 35]. Alkalamides and coumarins showed insecticidal activity against Sitophylus oryzae and Rhyzopertha dominica [36], polyacetylenes and terpenes have proven insecticide and repellent activities against larvae and adults of A. aegypti [37–39].…”

Section: Resultsmentioning

confidence: 99%

Development of nano-emulsions based onAyapana triplinervisfor the control ofAedes aegyptilarvae

Rodrigues

Lopes

Rabelo

et al. 2020

Preprint

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AbstractAyapana triplinervis is a plant species used in traditional medicine and in mystical-religious rituals by traditional communities in the Amazon. The aim of this study is to evaluate the larvicidal activity against A. aegypti of nano-emulsions containing essential oils from A. triplinervis morphotypes, and acute oral toxicity in non-target organism. Essential oils were identified and nano-emulsions were prepared using the low energy method. The mortality test of A. aegypti larvae was performed according to the protocol recommended by the World Health Organization, and toxicity in non-target mammals was performed according to the OECD. Phytochemical analyses indicated the major compounds (E)-Caryophyllene (45.93%) and Thymohydroquinone Dimethyl Ether (32.93%) in morphotype A, and in morphotype B, Thymohydroquinone Dimethyl Ether (84.53%) was found. Morphotype A essential oil nano-emulsion showed a particle size of 101.400 ± 0.971 nm (PdI = 0.124 ± 0.009 and ZP = −19,300 ± 0.787 mV). Morphotype B essential oil nano-emulsion had a particle size of 104.567 ± 0.416 nm (PdI = 0.168 ± 0.016 and ZP = −27,700 ± 1,307 mV). Histomorphological analyses showed the presence of inflammatory cells in the liver of animals treated with morphotype A essential oil nano-emulsion (MAEON) and morphotype B essential oil nano-emulsion (MBEON). Congestion and the presence of transudate with leukocyte infiltration in the lung of animals treated with MAEON were observed. The nano-emulsions containing essential oils of A. triplinervis morphotypes showed an effective nanobiotechnological product in the chemical control of A. aegypti larvae and safe for non-target mammals.

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Activities and Novel Applications of Secondary Metabolite Coumarins

Abstract: Planta Daninha 2018; v36:e018174040 HUSSAIN, M.I., QAMAR ABBAS, S., and REIGOSA, M.J. Activities and novel applications of secondary metabolite coumarins 1 151103- PD-2016 (9 páginas) PROVA GRÁFICA

Cited by 25 publications

References 73 publications

Phenolic Composition and Antimicrobial Activity of Different Emirati Date (Phoenix dactylifera L.) Pits: A Comparative Study

Phenolic Composition and Antimicrobial Activity of Different Emirati Date (Phoenix dactylifera L.) Pits: A Comparative Study

Development of nano-emulsions based on Ayapana triplinervis essential oil for the control of Aedes aegypti larvae

Development of nano-emulsions based onAyapana triplinervisfor the control ofAedes aegyptilarvae

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