Activité unitaire corticocérébelleuse et mouvements oculaires: Modifications associées aux saccades du sommeil et de la veille

Harlay, F.; Pellet, J; Tardy, M.; Dubrocard, S

doi:10.1016/0031-9384(74)90141-3

Cited by 15 publications

(2 citation statements)

References 19 publications

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“…Previous studies have described similar phasic events in the cerebellum and attributed them to propagation of PGO waves (Farber et al, 1980;Velluti et al, 1985). In keeping with our observations, PGO waves are found to be highly concentrated in REM epochs across multiple brain regions (Harlay et al, 1974;Marks et al, 1980;Pellet and Harley, 1977;Tsunematsu et al, 2020). Furthermore, PGO-waves are known to phase-lock to hippocampal theta rhythms during REM and modulate its frequency (increasing the preferred theta frequency; Karashima et al, 2007Karashima et al, , 2002.…”

Section: Cerebello-hippocampal Coherence During Sleepsupporting

confidence: 90%

“…Consistent with observations made in humans, during REM sleep a significant increase in the firing rate of Purkinje cells was observed in the cerebellar cortex of cats (Hobson and McCarley, 1972;Marchesi and Strata, 1970) and monkeys (Mano, 1970). The presence of large amplitude, phasic events in the cerebellum of cats (Harlay et al, 1974;Pellet and Harley, 1977) and rats (Marks et al, 1980), mainly during REM sleep epochs, has also been attributed to the transmission of pontogeniculo-occipital waves (PGO waves; Farber et al, 1980;Velluti et al, 1985). Finally, recent studies have highlighted cerebellar roles in the generation of sleep spindles in monkeys (Xu et al, 2020) and sleep-wake transitions in mice (Zhang et al, 2020).…”

Section: Introductionsupporting

confidence: 84%

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Delta Oscillations Coordinate Intracerebellar and Cerebello-Hippocampal Network Dynamics during Sleep

2022

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During sleep, the widespread coordination of neuronal oscillations across both cortical and subcortical brain regions is thought to support various physiological functions. However, how sleep-related activity within the brain's largest sensorimotor structure, the cerebellum, is multiplexed with well-described sleep-related mechanisms in regions such as the hippocampus remains unknown. We therefore simultaneously recorded from the dorsal hippocampus and three distinct regions of the cerebellum (Crus I, lobule VI, and lobules II/III) in male mice during natural sleep. Local field potential (LFP) oscillations were found to be coordinated between these structures in a sleep stage-specific manner. During non-REM sleep, prominent δ frequency coherence was observed between lobule VI and hippocampus, whereas non-REM-associated hippocampal sharp-wave ripple activity evoked discrete LFP modulation in all recorded cerebellar regions, with the shortest latency effects in lobule VI. We also describe discrete phasic sharp potentials (PSPs), which synchronize across cerebellar regions and trigger sharp-wave ripple suppression. During REM, cerebellar δ phase significantly modulated hippocampal theta frequency, and this effect was greatest when PSPs were abundant. PSPs were phase-locked to cerebellar δ oscillation peak and hippocampal theta oscillation trough, respectively. Within all three cerebellar regions, prominent LFP oscillations were observed at both low (δ, <4 Hz) and very high frequencies (∼250 Hz) during non-REM and REM sleep. Intracerebellar cross-frequency analysis revealed that δ oscillations modulate those in the very high-frequency range. Together, these results reveal multiple candidate physiological mechanisms to support “offline,” bidirectional interaction within distributed cerebello-hippocampal networks.SIGNIFICANCE STATEMENTSleep is associated with widespread coordination of activity across a range of brain regions. However, little is known about how activity within the largest sensorimotor region of the brain, the cerebellum, is both intrinsically organized and links with higher-order structures, such as the hippocampus, during sleep. By making multisite local field potential recordings in naturally sleeping mice, we reveal and characterize multiple sleep stage-specific physiological mechanisms linking three distinct cerebellar regions with the hippocampus. Central to these physiological mechanisms is a prominent δ (<4 Hz) oscillation, which temporally coordinates both intracerebellar and cerebello-hippocampal network dynamics. Understanding this distributed network activity is important for gaining insight into cerebellar contributions to sleep-dependent processes, such as memory consolidation.

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Section: Cerebello-hippocampal Coherence During Sleepsupporting

confidence: 90%

Section: Introductionsupporting

confidence: 84%

Delta Oscillations Coordinate Intracerebellar and Cerebello-Hippocampal Network Dynamics during Sleep

2022

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Functional linkage between the electrical activity in the vermal cerebellar cortex and saccadic eye movements

Llinás

Wolfe

1977

Exp Brain Res

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The temporal relation between the onset of electrical activity of Purkinje cells and the occurrence of rapid eye movements was studied. Experiments were performed in unanesthetized animals, the recordings being made under direct vision through the use of a chronically implanted teflon sleeve. The following results were obtained. 1. Correlation between the activity of Purkinje cells and eye movements indicates that Purkinje cell firing in vermal lobules VI and VII precedes eye movement by 11-12 msec, peak activity corresponding to the time of onset of eye movement. 2. This eye movement related activity of Purkinje cells occurred regardless of the direction of the eye movements but some cells showed directional biases. Best correlation between eye movement and Purkinje cell activity was found with fast eye movements toward the right regardless of recording side. 3. Electrical activity of Purkinje cells was mainly related to saccades. Slow eye movement modulation, although probably present, was not studied in detail. 4. In those cells where an extensive set of measurements could be made, Purkinje cell firing was found to be inversely proportional to the amplitude of the eye movement, small movements being preceded by highest Purkinje cell activity. The present results suggest that cerebellar vermis responds prior to the generation of eye movement and may probably serve to control eye movements in a ballistic manner.

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Nystagmic modulation of neuronal activity in rabbit cerebellar flocculus

1976

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1. The responses of neuronal elements in the flocculus of the awake, restrained rabbit were recorded during horizontal vestibular nystagmus in the dark. 2. Purkinje cells showed both vestibular (Types I and II) and eye movement modulation of simple spike activity. Type I Purkinje cells most commonly were inhibited in association with the ipsilaterally directed fast phase of nystagmus and excited during contralaterally directed fast phases. Type II Purkinje cells had a similar modulation but in the opposite direction. Variations on this pattern included an increase in firing during fast phases in both directions. 3. Presumed mossy fibers and granule cells also exhibited both vestibular and nystagmic modulation in various combinations. The nystagmic modulation often began during the fast phase and continued into the early part of the slow phase. Mossy fibers showing both vestibular and nystagmic modulation probably arise from the vestibular nuclei and/or the perihypoglossal nuclei. 4. Floccular control of brain stem nuclei utilizes not only vestibular but also eye movement signals and probably all sensory and internal signals involved in the regulation of gaze.

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Activité unitaire corticocérébelleuse et mouvements oculaires: Modifications associées aux saccades du sommeil et de la veille

Cited by 15 publications

References 19 publications

Delta Oscillations Coordinate Intracerebellar and Cerebello-Hippocampal Network Dynamics during Sleep

Delta Oscillations Coordinate Intracerebellar and Cerebello-Hippocampal Network Dynamics during Sleep

Functional linkage between the electrical activity in the vermal cerebellar cortex and saccadic eye movements

Nystagmic modulation of neuronal activity in rabbit cerebellar flocculus

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