Activité antifalcémiante d’extraits de trois plantes médicinales du Bukina Faso: <i>Jatropha curcas</i>, <i>Khaya senegalensis</i> et <i>Dichrostachys cinerea</i>

Abstract

RESUMEDans cette étude, une évaluation rétrospective sur 3 ans de la prévalence de l'hémoglobine S dans le Centre médical urbain de Samadin a été faite. Ensuite, les effets d'extraits aqueux de trois plantes utilisées dans le traitement de la drépanocytose chez des malades ont été évalués. L'évaluation de prévalence sur les dossiers de malades ayant réalisé une électrophorèse sur les trois dernières années dans le centre donne 87% pour AS, 2,4% pour SS et 10,6% pour SC. Elle a été faite sur 2133 patients dont 208 présentaient l'hémoglobine S. Pour évaluation des effets antifalcémiante de Jatropha curcas, Antisickling activity of extracts of three medicinal plants of Bukina Faso:Jatropha curcas, Khaya senegalensis and Dichrostachys cinerea ABSTRACT In this study a retrospective evaluation of sickling hemoglobin prevalence has been carried out during the last three years in Samadin urban medical center. In the other way, the effects of aqueous extract of three plants using in traditional treatment of sickle-cell anemia in Burkina Faso were studied. The results of S. SAWADOGO et al. / Int. J. Biol. Chem. Sci. 11(5): 2016-2027, 2017 2017 prevalence in the sickle-cell disease, in Samdin urban center made on 2133 patients out of which 208 presenting hemoglobin S had given 87% of AS, 2.4% of SS and 10.6% for SC. For evaluating the antisickling activities Jatropha curcas, of Khaya senegalensis and Dichrostachys cinerea, we incubed for 30 minutes cells globin AS in the aqueous extracts of these three plants and counted the residual sickling cells in the Emmel test. The results expressed in percentage are compared with those of blank example. We obtained 97% with Jatropha curcas, 32% with Khaya senegalensis and 91% with Dichrostachys cinerea. The results of the study show that the aqueous extracts of these three plants have some components with antisickling activities and support the traditional use of these plants in management of sickle-cell disease.

Phytochemical investigation and antisickling properties of a Poly-herbal formula on the HBSS Red Blood Cells

“…The excellent antisickling activity of ZHm extracts is thought to be due to a combination of the effects of several factors including the presence of amino acids, polyphenols, and the antioxidant power of these extracts. According to (Nur et al, 2012;, 2017) [28,37] , the antioxidant properties of phenolic compounds present in plant extracts could prevent membrane lipid peroxidation and thus prevent erythrocyte lysis.…”

Assessment of Radical Scavenging and Sickling Inhibitory Activities of the Bark of Disthemonanthus Benthamianus (Caesalpiniaceae)

“…In a state of hypoxia, the oxidative stress occurring during sickle cell disease could increase methemoglobin level in red blood cells and weakened free radicals defense system (Nur et al, 2011). Also, this increased methemoglobin level would decrease hemoglobin oxygen (Sawadogo et al, 2017;Kitadi et al, 2015). The reducing power could allow EDB and DDB to change the iron from Fe 3+ to Fe 2+ .…”

“…One of the reasons is that many diseases are treated successfully by plants (Kamanyi et al, 1995). Indeed, plants are source of natural bioactive molecules with antiinflammatory (Gonzalez et al, 2011), antimicrobial (Daglia, 2012), antiviral (Chavez et al, 2006), antisickling (Sawadogo et al, 2017;Kitadi et al, 2015;Akakpo et al, 2018), and antioxidant (Pandey & Rizvi, 2009;Diomandé et al, 2018) properties. The cost of patient care is not always affordable for lowincome populations.…”

<i>Gomphrena celosioides</i> (Amaranthaceae) aqueous extract effects on vascular reactivity of rats subjected to myocardial ischemia for 7 and 14 days

“…This study purpose was to evaluate GC effects on the susceptibility of cardiac muscle subjected to chronic ischemia for 7 and 14 days. Indeed, it is well known that many African plants contain active compounds in various diseases treatment (Traore et al, 2004 ;Lagnika et al, 2005;(Sawadogo et al, 2017). Some of these herbs are effective in high blood pressure treatment because they contain antihypertensive compounds relaxing vessels via endothelium that releases compounds such as nitric oxide (NO), and in ischemia case, cardiac or arterial muscles may be impaired in endothelial function (Varin et al, 1999); there is sometimes a reduction in vascular tone.…”