Activité Anti-Inflammatoire Et Études Phytochimiques De L’extrait Aqueux Des Écorces Distemonanthus Benthamianus Baill. (Caesalpiniaceae : Leguminosae - Caesalpinioideae)

John, Kouadio Kouakou; Shcherazade, Ouattara-Soro Fatou; Abizi, Georges; Ernest, Zougrou N’guessan; Roger, Kouakou Koffi; Emile, Begbin Kouassi; Mireille, Kplé Tatiana Kangah; Jean-Jacques, Kablan Kassi; Koffi, Séverin

doi:10.19044/esj.2021.v17n7p74

Cited by 2 publications

(5 citation statements)

References 22 publications

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“…The progression of edema after Carrageenan administration is a biphasic event, dependent on age and weight. Histamine, serotonin, and bradykinin are the first mediators to be detected in the early phase [28] and a late prostaglandinsupported phase is mediated by bradykinin, leukotrienes, and polymorphonuclear cells [29]. The significant inhibition of inflammation by ZHm extracts after 2 hours of edema induction, suggests the ability of the extracts to act on both the initial phases of acute inflammation.…”

Section: Discussionmentioning

confidence: 99%

The Impact of the Recipe from Zanthoxylum leprieurii Bark, Harungara madagascariensis Leaves and Xylopia aethiopica Fruits on Nociception and Inflammation in Wistar Rats

Kple

Akakpo-Akue²,

Ouattara³

et al. 2023

IJBcRR

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Inflammation has a major role in the pathophysiology of sickle cell disease, in fact when it is recurrent, it contributes more to the obstruction of blood vessels through several biochemical mechanisms by provoking vaso-occlusive crises. In order to mitigate these adverse effects in sickle cell patients, the analgesic and anti-inflammatory potentials of extracts of a combination of organs of three plants were evaluated in this study. The analgesic and anti- inflammatory activities of the aqueous (DZHm) and hydroethanolic (EZHm) extracts (200, 400 and 800 mg/kg) were evaluated in rats as models of acetic acid-induced torsion and Carrageenan-induced hind paw edema, using Diclofenac and Ibuprofen as reference molecules. Oral administration of ZHm extracts at doses of 200, 400 and 800 mg/kg produced anti-inflammatory and analgesic effects. These extracts significantly reduced edema and pain. These effects are time and dose dependent. In terms of analgesic effect, the dose of 800 mg/kg bw generated a high inhibition rate of 84.51% and 73.06% for DZHm and EZHm respectively, while the inhibition percentage of Ibuprofen was 78.3 ± 2.09 at the dose of 100 mg/kg bw. The anti-inflammatory effect was 60, 55% for DZHm, 56.08% for EZHm and 62.91% for Diclofenac at 10 mg/kg Pc. Diclofenac and Ibuprofen used for these two tests generated similar activities with ZHm extracts at the dose of 800 mg/kg Pc. The tested extracts (DZHm and EZHm) have analgesic and peripheral anti-inflammatory potentials justifying the use of this recipe in the traditional environment.

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Section: Discussionmentioning

confidence: 99%

The Impact of the Recipe from Zanthoxylum leprieurii Bark, Harungara madagascariensis Leaves and Xylopia aethiopica Fruits on Nociception and Inflammation in Wistar Rats

Kple

Akakpo-Akue²,

Ouattara³

et al. 2023

IJBcRR

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“…The anti-inflammatory activity test was carried out according to the method of Winter et al [2,12,13] with some modifications. It was carried out by induction of oedema in the right hind leg of the rat using carrageenan (1%).30 rats weighing between 120 g and 190 g were fasted for 12 h. These rats were divided into 5 groups of 6 rats each.…”

Section: Anti-inflammatory Activity Of Asthpadose Aqueous Extract (Eaa)mentioning

confidence: 99%

“…As for batches 4 and 5 (test batches), they received EAA at respective doses of 250 mg and 500 mg/kg bw 1 hour after administration of distilled water, Diclofenac and EAA by gavage, the 1% carrageenan, was injected cutaneously into the plantar aponeurosis of the right hind paw of each rat at a volume of 0.1 ml. The evolution of the oedema of the right paw was then determined at 1 h, 2 h, 3 h, 4 h, and 5 h [14] then the increase in oedema was assessed by determining the average percentage increase (%AUG) in the volume of the rat paw according to the formula: %AUG = ((Vt -V0) / V0) x 100 % AUG: Percentage increase of the paw Vt: Volume of the paw at time t V0: Initial volume of the paw [2,14] The anti-inflammatory activity was finally evaluated by calculating the percentage of inhibition (% INH) of oedema according to the formula:…”

Section: Anti-inflammatory Activity Of Asthpadose Aqueous Extract (Eaa)mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…Inflammation is a defense mechanism of the body against attacks of physical, chemical, biological or infectious origin [1,2]. This protective immune response can sometimes be harmful, linked to the pathogen and its persistence, to abnormalities in the regulation and production of pro-inflammatory cells [2,3]. As for coughing, it represents a means of sudden expulsion of air coming from the lungs thanks to the contraction of the expiratory muscles in order to rid the respiratory tract of foreign bodies and excessive secretions.…”

Section: Introductionmentioning

confidence: 99%

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Anti-Inflammatory and Antitussive Activity of Asthpadose, a Phytomedicine used in the Treatment of Asthma in Côte d'Ivoire

Léonce,

Bognan,

Raoul

et al. 2024

Asian J. Res. Biochem.

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Introduction: The aim of this study is to contribute to the valorisation of an anti- asthmatic phytomedicine (Asthpadose) traditionally used in Côte d'Ivoire. Aims: Evalute antiasthma’s activity of the aqueous extract of Asthpadose (EAA) was. Methodology: The antiasthma’s activity of the aqueous extract of Asthpadose (EAA) was evaluated by the determining of its anti-inflammatory activity using the carrageenan oedema induction method. This anti-asthmatic activity was also evaluated by its antitussive action on the frequency of cough induced in rats exposed to liquid ammonia. Results: The results revealed that EAA showed a very significant strong anti- inflammatory activity with an oedema inhibition rate ranging from 34.29% to 70.9 5%. This activity was much better than that of diclofenac sodium (a reference molecule against inflammation) with an oedema inhibition rate ranging from 12.24% to 58.39%. As for its antitussive activity, the results also showed good antitussive activity of the extract. EAA presented a cough inhibition rate of 74.22% compared to 58.76% for dextrometaphan which is also a reference molecule against cough. Conclusion: This observed activity could therefore justify the use of Asthpadose in the treatment of asthma which is a disease manifested by inflammation and cough. In view of the very promising results of this study, it would therefore be necessary to continue studies on this phytomedicine to understand its mechanism of action on asthma.

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Activité Anti-Inflammatoire Et Études Phytochimiques De L’extrait Aqueux Des Écorces Distemonanthus Benthamianus Baill. (Caesalpiniaceae : Leguminosae - Caesalpinioideae)

Cited by 2 publications

References 22 publications

The Impact of the Recipe from Zanthoxylum leprieurii Bark, Harungara madagascariensis Leaves and Xylopia aethiopica Fruits on Nociception and Inflammation in Wistar Rats

The Impact of the Recipe from Zanthoxylum leprieurii Bark, Harungara madagascariensis Leaves and Xylopia aethiopica Fruits on Nociception and Inflammation in Wistar Rats

Anti-Inflammatory and Antitussive Activity of Asthpadose, a Phytomedicine used in the Treatment of Asthma in Côte d'Ivoire

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