Activité anti-inflammatoire de l'extrait aqueux des feuilles de &lt;i&gt;Elaeis guineensis&lt;/i&gt; Jacq. (ARECACEAE) sur l'oedème aigu de la patte de rat induit par la carraghènine

Sene, Madièye; Mamadou, Ndiaye; Barboza, Firmin Sylva; Sène, Mbaye; Diatta, William; Sarr, Abdou; Ndiaye-Sy, Awa; Diéye, Amadou Moctar; Sy, Guata Yoro

doi:10.4314/ijbcs.v10i6.13

Cited by 9 publications

(8 citation statements)

References 19 publications

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“…Analysis of the phytochemical compounds of the leaves of Elaeis guineensis showed the presence of tannins, heterosides, saponins, flavonoids, steroids, reducing compound, coumarin, anthracenic derivatives, terpenoids and alkaloids. These results are similar to those found by (Assogba et al, 2015); (Sene et al, 2016); (Yin et al, 2013) and (Sasidharan et al, 2010) confirming the presence of the same chemical compounds in the leaves of Elaeis guineensis. Moreover, (Assogba et al, 2015) state that the aqueous extract of the leaves of Elaeis guineensis is very rich in tannins and saponosides.…”

Section: Phytochemical Screening Of the Stem Bark Of Khaya Senegalensis And Leaves Of Elaeis Guineensissupporting

confidence: 91%

Larval Cytotoxicity and Acute Oral Toxicity of Aqueous Extracts of Elaeis Guineensis Leaves and Khaya Senegalensis Stem Bark in Wistar Rats.

Soha¹

2019

IJAR

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Section: Phytochemical Screening Of the Stem Bark Of Khaya Senegalensis And Leaves Of Elaeis Guineensissupporting

confidence: 91%

Larval Cytotoxicity and Acute Oral Toxicity of Aqueous Extracts of Elaeis Guineensis Leaves and Khaya Senegalensis Stem Bark in Wistar Rats.

Soha¹

2019

IJAR

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“…The fact that the extracts inhibits very signi cantly (p <0.001) this chemical pain such as ASA at 200 mg/kg suggests that these extracts may interfere with these mediators like salicylics. Same observations were made in Uche et al [27] studies.…”

Section: Discussionsupporting

confidence: 78%

Anti-inflammatory, analgesic and antipyretic properties of ethanolic extracts of three plants of Benin pharmacopoeia: Euphorbia hirta, Citrus aurantifolia and Heterotis rotundifolia

Roko

Dougnon

Klotoé

et al. 2019

Preprint

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Objective Euphorbia hirta , Citrus aurantifolia and Heterotis rotundifolia are commonly used in Benin in the treatment of infectious diseases. The aim of this study is to evaluate the anti-in ammatory, analgesic and antipyretic properties of ethanolic extracts of these plants. The study was performed on wistar rats with 200 mg/kg b.w.Results Administration of these extracts prevents edema in ammatory induced by 2% formalin in rat paw. Inhibition percentages of edema vary between 23.67% and 86.76% for the three extracts. These extracts have similar anti-in ammatory activity (p> 0.05) to that of diclofenac at 50 mg/kg. Analgesic activity show that these extracts inhibit very signi cantly (p<0.001) the pain induced by 3% acetic acid and the highest inhibition percentage is 60.34% (Citrus aurantifolia ). This percentage is like to that of acetylsalicylic acid (67.35%) administered at the same dose. Likewise, these extracts attenuate signi cantly (p <0.05) the thermal pain induced by tail immersion of each rat in hot water at 50°C. Indeed, these extracts, reduces very signi cantly (p <0.001) pyrexia induced by 20% beer yeast suspension in rats and they have similar effect (p> 0.05) to that of acetylsalicylic acid at the fourth hour. These results prove, some traditional therapeutic indications of these plants.

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“…The highest edema inhibition percentages of extracts of these plants are 79.80% (EE-Eh), 86.75% (EE-Ca) and 83.07% (EE-Hr) obtained at fifth hour. These percentages are greater than 67.17% obtained with aqueous extract of Elaeis guineensis at 500ml/kg in Sene et al [27] studies. On the other hand, they are less than 98% and 90% obtained respectively with aqueous extracts of Sterculia setigera and the mixture Aframomum melegueta -Citrus aurantifolia at 1500 mg/kg in Gbénou et al [17] studies.…”

Section: Discussioncontrasting

confidence: 53%

Anti-inflammatory, Analgesic and Antipyretic Properties of Ethanolic Extracts of Three Plants of Beninese’s Pharmacopoeia: Euphorbia hirta, Citrus aurantifolia and Heterotis rotundifolia

Roko

Dougnon

Hounkpatin

et al. 2020

AJOB

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Background/Objective: Euphorbia hirta, Citrus aurantifolia and Heterotis rotundifolia are commonly used in Benin in the treatment of infectious diseases. The aim of this study is to evaluate the anti-inflammatory, analgesic and antipyretic properties of ethanolic extracts of these plants. Materials and Methods: The study was carried out on 30 wistar rats placed in 6 work lots. A positive control lot having received diclofenac and a negative control lot having received physiological water were used. The ethanolic extract of the plants was used at a dose of 200 mg / kg bw. The model of inflammatory edema of the rat paw induced by 2% formalin was used. Analgesic activity was assessed by the pain method induced by 3% acetic acid and the tail immersion method with wistar rats. The antipyretic effect was evaluated on pyrexia induced by brewer's yeast at 20% with wistar rats. Results: After injection of formalin to animals, inflammatory reaction was almost immediate with appearance of classic signs of acute local inflammation (Redness, pain, heat and edema) at the five experimental groups. This inflammatory reaction occurs in two phases. The first phase occurs between 0 and 2 hours after injection of phlogogenic agent and the second phase, initiated after two hours extending to the fifth hour and even beyond. Administration of these extracts prevents edema inflammatory and inhibition percentages of edema vary between 23.67% and 86.76% for the three extracts. These extracts have similar anti-inflammatory activity (p> 0.05) to that of diclofenac at 50 mg/kg. Analgesic activity show that these extracts inhibit very significantly (p<0.001) chemical pain induced by acetic acid and the highest inhibition percentage is 60.34% (Citrus aurantifolia). This percentage is like to that of acetylsalicylic acid (67.35%) administered at the same dose. Likewise, these extracts attenuate significantly (p <0.05) thermal pain induced by tail immersion of each rat in hot water at 50°C. Indeed, these extracts, reduces very significantly (p <0.001) pyrexia induced by 20% beer yeast suspension in rats and they have similar effect (p> 0.05) to that of acetylsalicylic acid at the fourth hour. Conclusion: These results show that the plants studied have the pharmacological properties evaluated. These results justify the use of these plants in traditional medicine.

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Activité anti-inflammatoire de l'extrait aqueux des feuilles de <i>Elaeis guineensis</i> Jacq. (ARECACEAE) sur l'oedème aigu de la patte de rat induit par la carraghènine

Cited by 9 publications

References 19 publications

Larval Cytotoxicity and Acute Oral Toxicity of Aqueous Extracts of Elaeis Guineensis Leaves and Khaya Senegalensis Stem Bark in Wistar Rats.

Larval Cytotoxicity and Acute Oral Toxicity of Aqueous Extracts of Elaeis Guineensis Leaves and Khaya Senegalensis Stem Bark in Wistar Rats.

Anti-inflammatory, analgesic and antipyretic properties of ethanolic extracts of three plants of Benin pharmacopoeia: Euphorbia hirta, Citrus aurantifolia and Heterotis rotundifolia

Anti-inflammatory, Analgesic and Antipyretic Properties of Ethanolic Extracts of Three Plants of Beninese’s Pharmacopoeia: Euphorbia hirta, Citrus aurantifolia and Heterotis rotundifolia

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