Activin gene expression increases after stroke injury: Modulation by estradiol

Böttner, Martina; Dubal, DB; Rau, SW; Wise, P. M.

doi:10.1055/s-2004-819199

Cited by 2 publications

(3 citation statements)

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“…We have begun to identify the repertoire of downstream genomic targets of estradiol action through ERs and, to date, have reported that estradiol modulates the expression of a several players in ischemic brain injury including the bcl‐2 family of genes that influence the extent of apoptotic cell death,21 (Fig. 3), immediate early genes,22 neuropeptides,23 and trophic factors 24…”

Section: An Animal Model Of Stroke: Middle Cerebral Artery Occlusionmentioning

confidence: 99%

Estrogens and Cerebrovascular Stroke: What Do Animal Models Teach Us?

Wise¹

2005

Annals of the New York Academy of Sciences

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Recent findings from the Women's Health Initiative (WHI) suggest that hormone therapy (HT) and estrogen therapy (ET) increase the risk of stroke in postmenopausal women. These results were unexpected based upon many previous clinical, observational, and epidemiological studies and a large body of evidence that come from studies performed in animal models. Before we assume that these results are widely applicable to other hormone preparations and to all older postmenopausal women, we should consider whether the particular hormone preparations, the doses that were used, the age of the women, the length of time that they were postmenopausal prior to the initiation of treatment, and/or their health status may have been important factors in the results of this clinical trial. We believe that results of studies using animal models provide insights into why the result of the WHI should have been expected. Furthermore, results of basic science studies provide a strong rationale for the design of future clinical studies that will more accurately test the effects of ET/HT on the risk and outcomes of cerebrovascular stroke in middle-aged perimenopausal and early postmenopausal women. We will review data, predominantly from our laboratory, gathered over the past six years that lead us to this conclusion.

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Section: An Animal Model Of Stroke: Middle Cerebral Artery Occlusionmentioning

confidence: 99%

Estrogens and Cerebrovascular Stroke: What Do Animal Models Teach Us?

Wise¹

2005

Annals of the New York Academy of Sciences

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“…estradiol modulates the expression of a several players in ischemic brain injury including survival factors, 139 immediate early genes, 141 neuropeptides, 142 and trophic factors. 143 Estrogen receptor-independent mechanisms and actions…”

Section: Molecular Mechanisms Of Estrogen-mediated Neuroprotectionmentioning

confidence: 99%

“…We have begun to identify the repertoire of downstream genomic targets of estradiol action through ERs and, to date, have reported that estradiol modulates the expression of a several players in ischemic brain injury including survival factors, 139 immediate early genes, 141 neuropeptides, 142 and trophic factors. 143 …”

Section: Molecular Mechanisms Of Estrogen-mediated Neuroprotectionmentioning

confidence: 99%

Estrogen and neuroprotection: from clinical observations to molecular mechanisms

Dubal

Wise

2002

Dialogues in Clinical Neuroscience

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We now appreciate that estrogen is a pleiotropic gonadal steroid that exerts profound effects on the plasticity and cell survival of the adult brain. Over the past century, the life span of women has increased, but the age of the menopause remains constant. This means that women may now live over one third of their lives in a hypoestrogenic, postmenopausal state. The impact of prolonged hypoestrogenicity on the brain is now a critical health concern as we realize that these women may suffer an increased risk of cognitive dysfunction and neurodegeneration due to a variety of diseases. Accumulating evidence from both clinical and basic science studies indicates that estrogen exerts critical protective actions against neurodegenerative conditions such as Alzheimer's disease and stroke. Here, we review the discoveries that comprise our current understanding of estrogen action against neurodegeneration. These findings carry far-reaching possibilities for improving the quality of life in our aging population.

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Activin gene expression increases after stroke injury: Modulation by estradiol

Cited by 2 publications

References 0 publications

Estrogens and Cerebrovascular Stroke: What Do Animal Models Teach Us?

Estrogens and Cerebrovascular Stroke: What Do Animal Models Teach Us?

Estrogen and neuroprotection: from clinical observations to molecular mechanisms

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