Activin and Activin Receptor Expression Changes in Liver Regeneration in Rat

Takamura, Kazuhito; Tsuchida, Kunihiro; Miyake, Hidenori; Tashiro, Seiki; Sugino, Hiromu

doi:10.1016/j.jss.2005.01.002

Cited by 49 publications

(42 citation statements)

References 34 publications

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“…By immunohistochemistry, significant activin beta C expression has been detected in cells from additional organs, including the prostate, ovary, testes, and pituitary gland [10,77] . After partial hepatectomy, a transient downregulation of activin beta C expression was observed by several studies [42,44,78,79] . We have found reduced activin beta C expression in HepG2 and Hep3B hepatoma cells versus normal liver tissue [80] and a drop of beta C expression was also described in rat hepatocytes during primary culture with and without EGF treatment [44] .…”

Section: Beta C and Beta Ementioning

confidence: 92%

Activins and follistatins: Emerging roles in liver physiology and cancer

Kreidl

Öztürk²,

Metzner³

et al. 2009

WJH

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Activins are secreted proteins belonging to the TGF-β family of signaling molecules. Activin signals are crucial for differentiation and regulation of cell proliferation and apoptosis in multiple tissues. Signal transduction by activins relies mainly on the Smad pathway, although the importance of crosstalk with additional pathways is increasingly being recognized. Activin signals are kept in balance by antagonists at multiple levels of the signaling cascade. Among these, follistatin and FLRG, two members of the emerging family of follistatin-like proteins, can bind secreted activins with high affinity, thereby blocking their access to cell surface-anchored activin receptors. In the liver, activin A is a major negative regulator of hepatocyte proliferation and can induce apoptosis. The functions of other activins expressed by hepatocytes have yet to be more clearly defined. Deregulated expression of activins and follistatin has been implicated in hepatic diseases including inflammation, fibrosis, liver failure and primary cancer. In particular, increased follistatin levels have been found in the circulation and in the tumor tissue of patients suffering from hepatocellular carcinoma as well as in animal models of liver cancer. It has been argued that up-regulation of follistatin protects neoplastic hepatocytes from activin-mediated growth inhibition and apoptosis. The use of follistatin as biomarker for liver tumor development is impeded, however, due to the presence of elevated follistatin levels already during preceding stages of liver disease. The current article summarizes our evolving understanding of the multi-faceted activities of activins and follistatins in liver physiology and cancer.

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Section: Beta C and Beta Ementioning

confidence: 92%

Activins and follistatins: Emerging roles in liver physiology and cancer

Kreidl

Öztürk²,

Metzner³

et al. 2009

WJH

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“…Formation of homodimeric activin C as well as heterodimeric activins AC, BC, CE, as well as inhibin C has been demonstrated by ectopic expression of the respective subunits in different cell models [14,70,71] . After partial hepatectomy a transient down-regulation of activin βC expression was observed by several studies [50,52,72,73] . A decrease of activin βC expression has also been observed in HepG2 and Hep3B hepatoma cells versus normal liver tissue [74] and in rat hepatocytes during primary culture with and without EGF treatment [52] .…”

Section: Antagonists In Liver Cancermentioning

confidence: 96%

“…Formation of homodimeric activin E as well as heterodimeric activins AE and CE has been demonstrated after ectopic co-expression of the respective subunits [14,16] . Activin βE mRNA expression was transiently up-regulated after partial hepatectomy or portal vein branch ligation [73,76] and in response to lipopolysaccharide treatment [81] . Increased βE expression has also been observed in hepatic fibrosis induced by CCl4 [75] .…”

Section: Activin βCmentioning

confidence: 99%

Activins and activin antagonists in hepatocellular carcinoma

Deli

Kreidl²,

Santifaller³

et al. 2008

WJG

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“…Activin not only play an important role in regulating secretion of hor mone, but also ser ves as autocrine and paracrine factors to regulate the differentiation, p r o l i f e r a t i o n , a p o p t o s i s o f c e l l s a n d e m b r yo n i c development [17][18][19][20][21] . The latest studies have reported that as an important regulator, activin also has effects on inducing liver fibrosis, suppressing hepatocyte growth and so on [21][22][23][24][25][26] .…”

Section: Discussionmentioning

confidence: 99%

Regulation of activin receptor-interacting protein 2 expression in mouse hepatoma Hepa1-6 cells and its relationship with collagen type IV

Zhou

Tai²,

Zhou³

et al. 2007

WJG

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AIM:To investigate the regulation of activin receptorinteracting protein 2 (ARIP2) expression and its possible relationships with collagen type Ⅳ (collagen Ⅳ) in mouse hepatoma cell line Hepal-6 cells. METHODS:The ARIP2 mRNA expression kinetics in Hepal-6 cells was detected by RT-PCR, and its regulation fa c t o r s w e re a n a l y ze d by t re a t m e n t w i t h s i g n a l transduction activators such as phorbol 12-myristate 13-acetate (PMA), forskolin and A23187. After pcDNA3-ARIP2 was transfected into Hepal-6 cells, the effects of ARIP2 overexpression on activin type Ⅱ receptor (ActRII) and collagen Ⅳ expression were evaluated. RESULTS:The expression levels of ARIP2 mRNA in Hapel-6 cells were elevated in time-dependent manner 12 h after treatment with activin A and endotoxin LPS, but not changed evidently in the early stage of stimulation (2 or 4 h). The ARIP2 mRNA expression was increased after stimulated with signal transduction activators such as PMA and forskolin in Hepal-6 cells, whereas decreased after treatment with A23187 (25.3% ± 5.7% vs 48.1% ± 3.6%, P < 0.01). ARIP2 overexpression could remarkably suppress the expression of ActRIIA mRNA in dose-dependent manner, but has no effect on ActRIIB in Hepal-6 cells induced by activin A. Furthermore, we have found that overexpression of ARIP2 could inhibit collagen Ⅳ mRNA and protein expressions induced by activin A in Hapel-6 cells. CONCLUSION:

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Activin and Activin Receptor Expression Changes in Liver Regeneration in Rat

Cited by 49 publications

References 34 publications

Activins and follistatins: Emerging roles in liver physiology and cancer

Activins and follistatins: Emerging roles in liver physiology and cancer

Activins and activin antagonists in hepatocellular carcinoma

Regulation of activin receptor-interacting protein 2 expression in mouse hepatoma Hepa1-6 cells and its relationship with collagen type IV

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