Activin A levels are raised during human tuberculosis and blockade of the activin signaling axis influences murine responses to
M. tuberculosis
infection
Natalie E. Nieuwenhuizen,
Geraldine Nouailles,
Jayne S. Sutherland
et al.
Abstract:Activin A strongly influences immune responses; yet, few studies have examined its role in infectious diseases. We measured serum activin A levels in two independent tuberculosis (TB) patient cohorts and in patients with pneumonia and sarcoidosis. Serum activin A levels were increased in TB patients compared to healthy controls, including those with positive tuberculin skin tests, and paralleled severity of disease, assessed by X-ray scores. In pneumonia patients, serum activin A levels were also raised, but i… Show more
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