Activin A inhibits growth-inhibitory signals by TGF-β1 in differentiated human endometrial adenocarcinoma cells

Tanaka, Tetsuji; Toujima, Saori; Umesaki, Naohiko

doi:10.3892/or.11.4.875

Cited by 10 publications

(11 citation statements)

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“…In prostate cancers, overproduction of activin A by tumor cells leads to increased angiogenesis, decreased immune surveillance, and increased epithelial-to-mesenchymal transition of the tumor cells, favoring tumor progression. 19 Overexpression of activin A in endometrial and esophageal carcinomas and malignant pleural mesotheliomas was associated with an induction of the proliferation via regulation of cyclin D. [20][21][22] Furthermore, activin A in the serum of patients with breast and prostate cancer with bone metastases are significantly higher than those of patients without bone metastases. 23 In addition, the activin A mRNA level was significantly associated with lymph node metastasis and clinical stage in esophageal carcinoma, and patients with high expression of activin A had a poor prognosis compared to those with low expression levels.…”

Section: Discussionmentioning

confidence: 99%

Activin A immunoexpression as predictor of occult lymph node metastasis and overall survival in oral tongue squamous cell carcinoma

et al. 2014

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Section: Discussionmentioning

confidence: 99%

Activin A immunoexpression as predictor of occult lymph node metastasis and overall survival in oral tongue squamous cell carcinoma

et al. 2014

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“…Since activin A has the ability to enhance proliferation in certain cancer cell lines (26), a role for activin A in endometrial tumorigenesis has been suggested (8,27). It has also been indicated that the increased activin A production in human endometrial adenocarcinoma cells in vitro may not stimulate carcinoma cell proliferation or inhibit apoptotic signaling in carcinoma cells, suggesting that the insensitivity to the usual growth suppression signals induced by activin A could instead be a mechanism of the immortality of human endometrial adenocarcinoma cells (28).…”

Section: Discussionmentioning

confidence: 99%

Expression of the inhibin/activin subunits (-α, -βA and -βB) in normal and carcinogenic endometrial tissue: Possible immunohistochemical differentiation markers

Worbs¹,

Shabani²,

Mayr³

et al. 2007

Oncol Rep

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Abstract. Inhibins (INH) are dimeric glycoproteins, composed of an alpha-subunit (INH-·) and one of two possible betasubunits (INH-ßA or -ßB), with substantial roles in human reproduction and in endocrine-responsive tumors. The aims of this study were to determine the frequency and tissue distribution of INH-·, -ßA and -ßB in normal and malignant endometria. Samples were obtained from normal (n=46), atrophic (n=8) and endometrioid carcinoma tissue (EC; G1=93; G2=32; G3=14). INH-· was significantly higher in normal compared to malignant endometrial tissue, showing a cyclical variation throughout the menstrual cycle. EC G3 did not express this subunit. INH-ßA and -ßB showed specific staining reactions within the tumor cells. The highest intensity of INH-ßA was observed in the normal secretory phase compared to adenocarcinomas (p<0.05). For INH-ßB, the significantly highest expression was noted in EC G3 compared to EC G2 (p<0.05) and atrophic endometrial tissue. In conclusion, INH-·, -ßA and -ßB were immunolabeled in normal and malignant endometria. INH-· was expressed in a declining relationship in the transition from normal to tumor tissue, suggesting a tumor suppressive function in EC. A high expression of INH-ßB was observed in EC G3 compared to G2, suggesting an important role in the progression of endometrial carcinogenesis. However, the utilization of these subunits as specific tumor markers still remains unclear.

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“…However, other reports indicate that activin A has no effect on proliferation in a clear cell adenocarcinoma cell line (27) and a negative effect on proliferation in an endometrioid adenocarcinoma cell line (28). Another study using three endometrioid adenocarcinoma cell lines reports that activin A has no effect on proliferation but can reverse the growth inhibitory effects of TGF-␤ (29).…”

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confidence: 94%

The Role of Activin A and Akt/GSK Signaling in Ovarian Tumor Biology

Kubba

Antenos

et al. 2008

Endocrinology

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Elevated activin A levels in serum, cyst fluid, and peritoneal fluid of ovarian cancer patients suggest a role for this peptide hormone in disease development. We hypothesize that activin A plays a role in ovarian tumor biology, and analyzed activin-mediated pro-oncogenic signaling in vitro and the expression of activin signaling pathway molecules in vivo. Activin A regulation of Akt and GSK, and the effects of repressing the activities of these molecules (with pharmacological inhibitors) on cellular proliferation were assessed in the cell line, OVCA429. Activin A activated Akt, which phosphorylated GSK, repressing GSK activity in vitro. Activin A stimulated cellular proliferation and repression of GSK augmented activin-regulated proliferation. To validate in vitro observations, immunostaining of the betaA-subunit of activin A and phospho-GSKalpha/beta (Ser9/21) was performed, and the correlation between immunoreactivity levels of these markers and survival was evaluated in benign serous cystadenoma, borderline tumor, and cystadenocarcinoma microarrays. Analysis of tissue microarrays revealed that betaA expression in epithelia did not correlate with survival or malignancy, but expression was elevated in stromal cells from carcinomas when compared with benign tumors. Phospho-GSKalpha/beta (Ser9/21) staining was more intense in mitotically active carcinoma cells and exhibited a polarized localization in benign neoplasms that was absent in carcinomas. Notably, lower phospho-GSKalpha/beta (Ser9/21) immunoreactivity correlated with better survival for carcinoma patients (P=0.046). Our data are consistent with a model in which activin A may mediate ovarian oncogenesis by activating Akt and repressing GSK to stimulate cellular proliferation.

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Activin A inhibits growth-inhibitory signals by TGF-β1 in differentiated human endometrial adenocarcinoma cells

Cited by 10 publications

References 0 publications

Activin A immunoexpression as predictor of occult lymph node metastasis and overall survival in oral tongue squamous cell carcinoma

Activin A immunoexpression as predictor of occult lymph node metastasis and overall survival in oral tongue squamous cell carcinoma

Expression of the inhibin/activin subunits (-α, -βA and -βB) in normal and carcinogenic endometrial tissue: Possible immunohistochemical differentiation markers

The Role of Activin A and Akt/GSK Signaling in Ovarian Tumor Biology

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