“…This effect of blocking activin A by follistatin was consistent with studies that have shown that activin A stimulates production of these cytokines, and other proinflammatory genes, in human, rat, and mouse mononuclear phagocytes in vitro (22,23,42). These data indicate a crucial role for activin A, and, consequently, for endogenous follistatin, in controlling the severity of acute inflammation and its subsequent actions.…”