Activin-A: active in inflammation in COPD

Tania, Navessa Padma; Schmidt, Martina; Gosens, Reinoud

doi:10.1183/09031936.00011414

Cited by 7 publications

(6 citation statements)

References 13 publications

(18 reference statements)

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“…Moreover, recent evidence suggested that Activin A activated signaling in the development and progression of muscle wasting via the ActRIIB, which may be regarded as a therapeutic target for cachexia 8. In line with the observation showing the upregulated expression of Act A in the airway epithelium, airway smooth muscle and alveolar macrophages of COPD patients 10,34, we found increased circulating levels of Act A in COPD patients. Furthermore, to the best of our knowledge, we established the first negative correlations between elevated serum levels of Act A and muscle mass index as BMI, SMM and FFMI in our study, which indicated the contributing role of Act A in muscle degradation in COPD.…”

Section: Discussionsupporting

confidence: 88%

Elevated serum Activin A in chronic obstructive pulmonary disease with skeletal muscle wasting

Zhou¹,

Gui²,

Chen³

et al. 2019

Clinics

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OBJECTIVE: Muscle wasting contributes to the reduced quality of life and increased mortality in chronic obstructive pulmonary disease (COPD). Muscle atrophy in mice with cachexia was caused by Activin A binding to ActRIIB. The role of circulating Activin A leading to muscle atrophy in COPD remains elusive. METHODS: In the present study, we evaluated the relationship between serum levels of Activin A and skeletal muscle wasting in COPD patients. The expression levels of serum Activin A were measured in 78 stable COPD patients and in 60 healthy controls via ELISA, which was also used to determine the expression of circulating TNF-α levels. Total skeletal muscle mass (SMM) was calculated according to a validated formula by age and anthropometric measurements. The fat-free mass index (FFMI) was determined as the fat-free mass (FFM) corrected for body surface area. RESULTS: Compared to the healthy controls, COPD patients had upregulated Activin A expression. The elevated levels of Activin A were correlated with TNF-α expression, while total SMM and FFMI were significantly decreased in COPD patients. Furthermore, serum Activin A expression in COPD patients was negatively associated with both FFMI and BMI. CONCLUSION: The above results showed an association between increased circulating Activin A in COPD patients and the presence of muscle atrophy. Given our previous knowledge, we speculate that Activin A contributes to skeletal muscle wasting in COPD.

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Section: Discussionsupporting

confidence: 88%

Elevated serum Activin A in chronic obstructive pulmonary disease with skeletal muscle wasting

Zhou¹,

Gui²,

Chen³

et al. 2019

Clinics

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“…Although in vitro experiments have uncovered neutrophils as an important source of activin A ll OPEN ACCESS (Chen et al, 2011) and elevated activin A levels occur in diseases characterized by neutrophil activation, which suggest that a relationship between neutrophils and activin A may be anything but coincidental (Sideras et al, 2013), it was only recently that our studies demonstrated an expression of activin signaling components in neutrophils and that activin A can in fact modulate neutrophil function in an autocrine and paracrine manner Xie et al, 2017). Moreover, elevated activin A levels and an impairment of neutrophil chemotaxis have previously been described in multiple inflammatory and infectious diseases, such as sepsis, chronic obstructive pulmonary disease, cancer, and diabetes (Bian et al, 2019;Brandau et al, 2011;Hoda et al, 2016;Tania et al, 2014;Trevelin et al, 2017;Yoshikawa et al, 2007;Zhang et al, 2016;Zhong et al, 2019). However, the relationship between these two phenomena has so far not been explored.…”

Section: Introductionmentioning

confidence: 53%

Activin A impairs ActRIIA+ neutrophil recruitment into infected skin of mice

Jiang

et al. 2021

iScience

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Summary Activin A levels are elevated during multiple severe infections and associated with an increased risk of death. However, the role of activin A in bacterial infection is still unclear. Here, we found that activin A levels were increased during S. aureus skin infection in mice. Administration of activin A increased the bacterial burden and promoted the spread of bacteria in vivo . Moreover, activin A inhibited neutrophil chemotaxis to N-formylmethionine-leucyl-phenylalanine via the type IIA activin receptor (ActRIIA) in vitro and impaired ActRIIA + neutrophil recruitment to infection foci in vivo . Additionally, we identified a novel subpopulation of neutrophils, ActRIIA + neutrophils, which exhibit superior phagocytic capacity compared to ActRIIA − neutrophils and possess an N2-like immunoregulatory activity via secreting IL-10 and TGF-β. Taken together, these findings indicate that activin A inhibits the recruitment of ActRIIA + neutrophils to infected foci, leading to the impairment of bacterial clearance, and thus may hamper early infection control.

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“…One of the pathogenic mechanisms of sepsis encephalopathy is the activation of inflammation and apoptosis, for which TNF-α and IL-6 are the two most important inflammatory cytokines, produced in the early stages of this disease (Sun et al, 2017 ). activin A promotes the expression of TNF-α, IL-6, and IL-1, in inflammatory and immune reactions, and eventually promotes the occurrence of inflammatory responses (Tania et al, 2014 ). In addition, studies have shown that serum activin A is elevated during acute and chronic inflammation, which may further increase the uninhibited inflammatory response leading to multiple organ failure and even death (Lee et al, 2016 ).…”

Section: Activin a And Brain Injurymentioning

confidence: 99%

Research Progress on the Role and Mechanism of Action of Activin A in Brain Injury

Huang

Xiao

et al. 2018

Front. Neurosci.

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Activin A belongs to the transforming growth factor superfamily and has a variety of biological functions. Studies have revealed that activin A can regulate the body's immune and inflammatory responses and participate in the regulation of cell death. In addition, activin A also has neurotrophic function and plays an important role in the repair of brain damage. This article summarizes recent advances in understanding the role and mechanism of action of activin A in brain injury and provides new hints into the application of activin A in the treatment of brain injury.

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Activin-A: active in inflammation in COPD

Cited by 7 publications

References 13 publications

Elevated serum Activin A in chronic obstructive pulmonary disease with skeletal muscle wasting

Elevated serum Activin A in chronic obstructive pulmonary disease with skeletal muscle wasting

Activin A impairs ActRIIA+ neutrophil recruitment into infected skin of mice

Research Progress on the Role and Mechanism of Action of Activin A in Brain Injury

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