Active zones for presynaptic plasticity in the brain

García-Junco-Clemente, Pablo; Linares-Clemente, Pedro; Fernández‐Chacón, Rafael

doi:10.1038/sj.mp.4001628

Cited by 22 publications

(13 citation statements)

References 174 publications

(216 reference statements)

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“…Therefore, our results suggest that CAPS2 is critical for the enhancement of regulated BDNF secretion but that CAPS2 is not essential for regulated secretion. Recent studies have shown that CAPS promotes trans-soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complex formation in DCV exocytosis (26), and an alternative pathway or proteins, such as mammalian homologue of C. elegans unc13-1 (Munc13-1) (27) and CAPS1 (4), could substitute for CAPS2 in CAPS2-KO neurons. In the latter study, CAPS2 was proposed to promote SV exocytosis.…”

Section: Discussionmentioning

confidence: 99%

Calcium-dependent activator protein for secretion 2 (CAPS2) promotes BDNF secretion and is critical for the development of GABAergic interneuron network

Shinoda

Sadakata

Nakao

et al. 2010

Proc. Natl. Acad. Sci. U.S.A.

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Calcium-dependent activator protein for secretion 2 (CAPS2) is a dense-core vesicle-associated protein that is involved in the secretion of BDNF. BDNF has a pivotal role in neuronal survival and development, including the development of inhibitory neurons and their circuits. However, how CAPS2 affects BDNF secretion and its biological significance in inhibitory neurons are largely unknown. Here we reveal the role of CAPS2 in the regulated secretion of BDNF and show the effect of CAPS2 on the development of hippocampal GABAergic systems. We show that CAPS2 is colocalized with BDNF, both synaptically and extrasynaptically in axons of hippocampal neurons. Overexpression of exogenous CAPS2 in hippocampal neurons of CAPS2-KO mice enhanced depolarization-induced BDNF exocytosis events in terms of kinetics, frequency, and amplitude. We also show that in the CAPS2-KO hippocampus, BDNF secretion is reduced, and GABAergic systems are impaired, including a decreased number of GABAergic neurons and their synapses, a decreased number of synaptic vesicles in inhibitory synapses, and a reduced frequency and amplitude of miniature inhibitory postsynaptic currents. Conversely, excitatory neurons in the CAPS2-KO hippocampus were largely unaffected with respect to field excitatory postsynaptic potentials, miniature excitatory postsynaptic currents, and synapse number and morphology. Moreover, CAPS2-KO mice exhibited several GABA system-associated deficits, including reduced late-phase long-term potentiation at CA3-CA1 synapses, decreased hippocampal theta oscillation frequency, and increased anxiety-like behavior. Collectively, these results suggest that CAPS2 promotes activity-dependent BDNF secretion during the postnatal period that is critical for the development of hippocampal GABAergic networks.dense-core vesicles | brain-derived neurotrophic factor | GABAergic synapse

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Section: Discussionmentioning

confidence: 99%

Calcium-dependent activator protein for secretion 2 (CAPS2) promotes BDNF secretion and is critical for the development of GABAergic interneuron network

Shinoda

Sadakata

Nakao

et al. 2010

Proc. Natl. Acad. Sci. U.S.A.

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“…The interaction of 14-3-3 proteins with RIMs is regulated by the phosphorylation status of RIMs as only RIM that is phosphorylated at serine 413 binds to 14-3-3 proteins (Lonart et al 2003). RIM mutants have been analyzed in C. elegans (Koushika et al 2001) and in mice in which RIM1α knockouts have been studied in great detail (for reviews, see Garcia-Junco-Clemente et al 2005;Kaeser and Sudhof 2005). UNC-10 mutants of C. elegans exhibit a five-fold reduction in fusion-competent vesicles at release sites (Koushika et al 2001).…”

Section: -3-3 (Simsek-duran Et Al 2004)mentioning

confidence: 99%

Molecular organization of the presynaptic active zone

2006

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The exocytosis of neurotransmitter-filled synaptic vesicles is under tight temporal and spatial control in presynaptic nerve terminals. The fusion of synaptic vesicles is restricted to a specialized area of the presynaptic plasma membrane: the active zone. The protein network that constitutes the cytomatrix at the active zone (CAZ) is involved in the organization of docking and priming of synaptic vesicles and in mediating use-dependent changes in release during short-term and long-term synaptic plasticity. To date, five protein families whose members are highly enriched at active zones (Munc13s, RIMs, ELKS proteins, Piccolo and Bassoon, and the liprins-alpha), have been characterized. These multidomain proteins are instrumental for the diverse functions performed by the presynaptic active zone.

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“…However, zinc, copper and magnesium have been reported to block the channel and causing antagonistic effects (Eby and Eby, 2006; Gass and Olive, 2008; Huggins and Grant, 2005; Rambo et al, 2012; Trombley et al, 1998). These receptors have been mostly found on presynaptic nerve-terminals and glial cells (Garcia-Junco-Clemente et al, 2005; Paoletti and Neyton, 2007), with an implication in neural plasticity (Coyle and Tsai, 2004; Malenka and Nicoll, 1993; Paoletti et al, 2013). …”

Section: Glutamate Receptors In Audmentioning

confidence: 99%

Metabotropic and ionotropic glutamate receptors as potential targets for the treatment of alcohol use disorder

Goodwani

Saternos

Alasmari

et al. 2017

Neuroscience & Biobehavioral Reviews

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Emerging evidence indicates that dysfunctional glutamate neurotransmission is critical in the initiation and development of alcohol and drug dependence. Alcohol consumption induced downregulation of glutamate transporter 1 (GLT-1) as reported in previous studies from our laboratory. Glutamate is the major excitatory neurotransmitter in the brain, which acts via interactions with several glutamate receptors. Alcohol consumption interferes with the glutamatergic signal transmission by altering the functions of these receptors. Among the glutamatergic receptors involved in alcohol-drinking behavior are the metabotropic receptors such as mGluR1/5, mGluR2/3, and mGluR7, as well as the ionotropic receptors, NMDA and AMPA. Preclinical studies using agonists and antagonists implicate these glutamatergic receptors in the development of alcohol use disorder (AUD). Therefore, the purpose of this review is to discuss the neurocircuitry involving glutamate transmission in animals exposed to alcohol and further outline the role of metabotropic and ionotropic receptors in the regulation of alcohol-drinking behavior. This review provides ample information about the potential therapeutic role of glutamatergic receptors for the treatment of AUD.

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Active zones for presynaptic plasticity in the brain

Cited by 22 publications

References 174 publications

Calcium-dependent activator protein for secretion 2 (CAPS2) promotes BDNF secretion and is critical for the development of GABAergic interneuron network

Calcium-dependent activator protein for secretion 2 (CAPS2) promotes BDNF secretion and is critical for the development of GABAergic interneuron network

Molecular organization of the presynaptic active zone

Metabotropic and ionotropic glutamate receptors as potential targets for the treatment of alcohol use disorder

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