To tackle the active control problem of the heavy platform-struts structure, this paper designs a kind of hydraulic servo actuator that can withstand large static load and generate high-precision, small-amplitude dynamic forces as well, and develops a multi-channel cross-coupling suppression control algorithm that can consider the strong coupling effect in structure. Subsequently, combining the designed actuators with the control algorithm, this paper puts forward an active heavy platform-struts structure vibration control method. By embedding the designed actuators into the support struts, a platform-struts structure experimental system is constructed to assess the vibration suppression effect of the proposed method. Excited by the amplitude-varying disturbing force, four different kinds of experiments are conducted. The experimental results show that the distributed multi-channel adaptive active control method without considering the coupling effect will lead to the instability, and the vibration attenuation of the proposed method in this paper exceeds 90%. The proposed method therefore has an important potential in addressing the problem of vibration suppression in the practical engineering. In addition, it has strong convergence and robustness.