Active vaccination in patients with common variable immunodeficiency (CVID)

Goldacker, Sigune; Draeger, Ruth; Warnatz, Klaus; Huzly, Daniela; Salzer, U; Thiel, Jens; Eibel, Hermann; Schlesier, Michael; Peter, Hans‐Hartmut

doi:10.1016/j.clim.2007.04.011

Cited by 94 publications

(86 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, recent evidence indicates that ϳ20% of patients with CVID have positive response to both protein and polysaccharide vaccines and ϳ58% have single positive antibody response after immunization (38). Therefore, the positive response to vaccines is not contradictory to the diagnosis of CVID (38,39). We demonstrated that in children with CVID, in contrary to THI, the development of memory B-cell subsets is disturbed.…”

Section: Discussionmentioning

confidence: 70%

The B-cell Compartment in the Peripheral Blood of Children With Different Types of Primary Humoral Immunodeficiency

et al. 2009

View full text Add to dashboard Cite

ABSTRACT:The aim of this study was to evaluate the B-cell compartment in the peripheral blood of children with different types of hipogammaglobulinemia: common variable immunodeficiency (CVID), transient hypogammaglobulinemia of infancy (THI), and selective IgA deficiency (SIgAD). We analyzed by flow cytometry the changes in the B-cell subsets with age and showed that children with an early-onset CVID develop similar pattern of B-cell subsets as adult patients with CVID with age, as the levels of memory B cells (CD19 ϩ /CD27 ϩ ) and class-switched memory B cells (, in contrast to age-matched control group, did not increase with age. Children with SIgAD displayed similar changes as patients with CVID only within the class-switched memory B-cell subpopulation. No significant differences in the level of memory B cells and class-switched memory B cells in children with THI in comparison to age-matched control group were observed. There were no differences in the percentage of immature B cells (CD19 ϩ /CD21 low ) among all studied groups. As B-cell subsets in children with THI were normal during entire period of hypogammaglobulinemia, the persistence of low levels of memory B-cell subsets in some children may facilitate the diagnosis of CVID. (5), or primary B-cell defects (6,7) have been reported. In some patients with CVID, defects in B-cell receptors signaling and B cell development have been described, especially mutations in CD19 (8), B-cell activating factor of the tumor necrosis factor family receptor (BAFF-R) (9), inducible costimulator of activated T cells (ICOS) (10), and transmembrane activator and CAML interactor (TACI) (11-14), which are required for maturation of B cells and generation of antibody diversity. Disease is usually diagnosed in the second or third decade of life after a history of recurrent pyogenic sinopulmonary infections (15), but some cases of CVID are diagnosed in the childhood as an early-onset CVID.Selective IgA deficiency (SIgAD) is the most prevalent primary humoral immunodeficiency. The clinical picture of SIgAD may vary from absence of clinical manifestations to fully symptomatic form (16). A variety of pathologic mechanisms of SIgAD have been postulated, which include the occurrence of IgA-specific T suppressor cells, inadequate T helper (Th) cell function, an intrinsic B-cell defects (17), or decreased expression of CD40 on monocytes (18). In most cases, the molecular defect is unknown, although in some patients with SIgAD, mutations in TACI gene have been identified (11,12). SIgAD is considered to be genetically linked with CVID, as the latter may develop from SIgAD (19 -21) and occasionally vice versa (22). Familial studies have implicated the existence of an allelic relationship between SIgAD and CVID, indicating that these disorders have the same molecular defect (23).Transient hypogammaglobulinemia of infancy (THI) is defined by decreased level of IgG (below 2 SD for the agematched healthy children) and in some cases low level of IgA and intact cell-mediated immunity. Prod...

show abstract

Section: Discussionmentioning

confidence: 70%

The B-cell Compartment in the Peripheral Blood of Children With Different Types of Primary Humoral Immunodeficiency

et al. 2009

View full text Add to dashboard Cite

show abstract

“…However, there appear to be subgroups of patients capable of at least transiently generating adequate antibody responses to the antigens of polysaccharide or protein-based vaccines [107][108][109][110]. Due to the high degree of uncertainty surrounding the degree of IMD risk of IMD, the NNV was not estimated for this patient group.…”

Section: Potential Efficacy Of a 4cmenb Vaccination In Antibody Deficmentioning

confidence: 99%

Background Paper for the update of meningococcal vaccination recommendations in Germany: use of the serogroup B vaccine in persons at increased risk for meningococcal disease

Hellenbrand

Koch

Harder

et al. 2015

Bundesgesundheitsbl.

View full text Add to dashboard Cite

“…The cells were investigated before (day 0) and on day 7 after vaccination. HC -healthy control; CVID -CVID patient, PB27 ++ and PB38 ++ -plasmablasts classifications of CVID (Goldacker et al 2007;). Our group of CVID patients was arranged according to the Freiburg (Warnatz et al 2002) and EUROclass classification (Wehr et al 2008).…”

Section: Hypogammaglobulinaemic Patients and Diagnostic Vaccinationmentioning

confidence: 99%

“…Goldacker et al (Goldacker et al 2007) measured specific antibodies in serum by ELISA assay. The contribution of parallel immunoglobulin substitution on antibody titers was difficult to correct and required a relatively complicated vaccination formula.…”

Section: Hypogammaglobulinaemic Patients and Diagnostic Vaccinationmentioning

confidence: 99%

Flow Based Enumeration of Plasmablasts in Peripheral Blood After Vaccination as a Novel Diagnostic Marker for Assessing Antibody Responses in Patients with Hypogammaglobulinaemia

Thon¹,

Vlková²,

Chovancová³

et al. 2012

Clinical Flow Cytometry - Emerging Applications

View full text Add to dashboard Cite

Active vaccination in patients with common variable immunodeficiency (CVID)

Cited by 94 publications

References 34 publications

The B-cell Compartment in the Peripheral Blood of Children With Different Types of Primary Humoral Immunodeficiency

The B-cell Compartment in the Peripheral Blood of Children With Different Types of Primary Humoral Immunodeficiency

Background Paper for the update of meningococcal vaccination recommendations in Germany: use of the serogroup B vaccine in persons at increased risk for meningococcal disease

Flow Based Enumeration of Plasmablasts in Peripheral Blood After Vaccination as a Novel Diagnostic Marker for Assessing Antibody Responses in Patients with Hypogammaglobulinaemia

Contact Info

Product

Resources

About