Active Type Sensors for Breath Gas Analysis

Pospelov, А. P.; Kushch, Ievgeniia; Alexandrov, Yu. L.; Pletnev, A. M.; Kamarchuk, G. V.

doi:10.18524/1815-7459.2007.2.113793

Cited by 10 publications

(8 citation statements)

References 3 publications

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“…Shortly after the beginning of the interaction with breath, the substance transits to a quasi-equilibrium state, where its electric conductivity remains constant or changes negligibly under breath action. This finding was demonstrated elsewhere in [39,40]. The reason for this behavior is as follows.…”

Section: Resultssupporting

confidence: 67%

Evidence for sensory effects of a 1D organic conductor under gas exposure

Pyshkin¹,

Kamarchuk²,

Yeremenko³

et al. 2011

J. Breath Res.

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This work describes the gas-sensitive properties of a one-dimensional organic conductor before and after exposure to carbon monoxide and human breath. A sensitive material, an anion-radical salt of tetracyanoquinodimethane, has been investigated by infrared spectroscopy and electrical resistivity measurements. Drastic spectral and electrical changes are found after gas exposure showing that the compound interacts strongly with human breath, carbon monoxide, and ammonia. Under breath action the resistance changes by more than three orders of magnitude while the adsorption of CO, one of the components of breath, results in a decrease in both IR absorption and electrical conductivity. The intensity of the IR absorption spectrum of the material in the CO medium decreases down to 30% in the 2180-2500 cm(-1) range. This absorption varies by about 10% between 750 and 2500 cm(-1) after breath action. Direct electrical measurements show that actions of donor or acceptor gas result in opposite changes of electric resistance. The electrical resistance of the sample can drop down to 0.4 MΩ due to the pulse action of ammonia at 4 ppm concentration, while it increases upon exposure to carbon monoxide media at concentrations of 6-25 ppm. The response signal of the investigated samples changes proportionally to the concentration of the acting gas. The results substantiate prominent gas sensitivity of the investigated material, which might find applications for breath analysis, in particular, for the development of noninvasive diagnosis of gastric diseases.

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Section: Resultssupporting

confidence: 67%

Evidence for sensory effects of a 1D organic conductor under gas exposure

Pyshkin¹,

Kamarchuk²,

Yeremenko³

et al. 2011

J. Breath Res.

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“…Similarly to the Yanson point-contact spectroscopy, this parameter reflects in an integrated way the interaction function between electrons in the contact and all components of the analyzed gaseous medium. This function is very sensitive to changes in the composition and state of the breath, as well as to the concentration of certain components that contribute significantly to the change in the conductance of the contact as they are adsorbed [37,38].…”

Section: Resultsmentioning

confidence: 99%

“…Sensor matrix is an energetically autonomous structure which contains an integrated galvanic element to ensure a precise correlation between all changes in its physicochemical properties during measurements and the response signal. To create this internal source of accumulated energy of the active sensing element, the process of electrochemical synthesis described in [37] was used. The presence of an internal source of energy was needed to ensure autonomy and a better durability (more than a year) of point-contact sensors without any external sources of energy, so that even experiments in the field conditions were possible.…”

Section: Methodsmentioning

confidence: 99%

“…This means that the energy information contained in the spectrum can be used to reliably identify the contribution of any substance. An alternative approach to analyzing point-contact spectral profiles of exhaled breath, which could be a powerful tool to obtain unique information in a different way, is using their characteristic parameters [23,37,38]. This approach was successfully applied, for example, to develop a new method for detection of carcinogenic strains of the bacterium H. pylori [23].…”

Section: Introductionmentioning

confidence: 99%

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Noninvasive real-time breath test for controlling hormonal background of the human body: detection of serotonin and melatonin with quantum point-contact sensors

Kamarchuk¹,

Pospelov²,

Harbuz³

et al. 2021

J. Breath Res.

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Significant progress in development of noninvasive diagnostic tools based on breath analysis can be expected if one employs a real-time detection method based on finding a spectral breath profile which would contain some energy characteristics of the analyzed gas mixture. Using the fundamental energy parameters of a quantum system, it is possible to determine with a high accuracy its quantitative and qualitative composition. Among the most efficient tools to measure energy characteristics of quantum systems are sensors based on Yanson point contacts. This paper reports the results of serotonin and melatonin detection as an example of testing the human hormonal background with point-contact sensors, which have already demonstrated their high efficiency in detecting carcinogenic strains of Helicobacter pylori and selective detection of complex gas mixtures. When comparing the values of serotonin and melatonin with the characteristic parameters of the spectral profile of the exhaled breath of each patient, high correlation dependences of the concentration of serotonin and melatonin with a number of characteristic parameters of the response curve of the point-contact sensor were found. The performed correlation analysis was complemented with the regression analysis. As a result, empiric regression relations were proposed to realize in practice the new non-invasive breath test for evaluation of the human hormonal background. Registration of the patient’s breath profile using point-contact sensors makes it possible to easily monitor the dynamics of changes in the human hormonal background and perform a quantitative evaluation of serotonin and melatonin levels in the human body in real time without invasive interventions (blood collection) and expensive equipment or reagents.

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“…The mesoscopic point-contact sensor matrix has a small integrated source of energy, which is manufactured with a special technique during the synthesis of this nanostructure. The production of the energy source and the matrix as a whole is based on electrochemical processes described previously [ 34 , 37 – 38 ]. The applied technology guaranteed high reliability and longevity to the sensor elements.…”

Section: Methodsmentioning

confidence: 99%

Selective detection of complex gas mixtures using point contacts: concept, method and tools

Pospelov¹,

Belan²,

Harbuz³

et al. 2020

Beilstein J. Nanotechnol.

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Of all modern nanosensors using the principle of measuring variations in electric conductance, point-contact sensors stand out in having a number of original sensor properties not manifested by their analogues. The nontrivial nature of point-contact sensors is based on the unique properties of Yanson point contacts used as the sensing elements. The quantum properties of Yanson point contacts enable the solution of some of the problems that could not be solved using conventional sensors measuring conductance. In the present paper, we demonstrate this by showing the potential of quantum point-contact sensors to selectively detect components of a gas mixture in real time. To demonstrate the high efficiency of the proposed approach, we analyze the human breath, which is the most complex of the currently known natural gas mixtures with extremely low concentrations of its components. Point-contact sensors allow us to obtain a spectroscopic profile of the mixture. This profile contains information about the complete set of energy interactions occurring in the point contact/breath system when the breath constituents adsorb to and desorb from the surface of the point-contact conduction channel. With this information we can unambiguously characterize the analyzed system, since knowing the energy parameters is key to successfully identifying and modeling the physicochemical properties of various quantum objects. Using the point-contact spectroscopic profile of a complex gas mixture it is possible to get a functional dependence of the concentration of particular breath components on the amplitude of the sensor output signal. To demonstrate the feasibility of the proposed approach, we analyze the point-contact profiles from the breath of several patients and compare them with the concentrations of serotonin and cortisol in the body of each patient. The obtained results demonstrate that the proposed methodology allows one to get an effective calibration function for a non-invasive analysis of the level of serotonin and cortisol in the human body using the point-contact breath test. The present study indicates some necessary prerequisites for the design of fast detection methods using differential sensor analysis in real time, which can be implemented in various areas of science and technology, among which medicine is one of the most important.

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Active Type Sensors for Breath Gas Analysis

Cited by 10 publications

References 3 publications

Evidence for sensory effects of a 1D organic conductor under gas exposure

Evidence for sensory effects of a 1D organic conductor under gas exposure

Noninvasive real-time breath test for controlling hormonal background of the human body: detection of serotonin and melatonin with quantum point-contact sensors

Selective detection of complex gas mixtures using point contacts: concept, method and tools

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