Active Transport of Nitrofurantoin into Human Milk

Gerk, Phillip M.; Kuhn, Robert J.; Desai, Nirmala S.; McNamara, Patrick J.

doi:10.1592/phco.21.7.669.34574

Cited by 69 publications

(39 citation statements)

References 27 publications

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“…The ability of the mammary gland to concentrate pharmaceuticals such as nitrofurantoin and cimetidine in human breast milk has been recognized (Oo et al, 1995;Gerk et al, 2001). More recently, it was hypothesized that drug transporters may be important in the active transport of chemicals into breast milk.…”

Section: Mammary Glandsmentioning

confidence: 99%

Xenobiotic, Bile Acid, and Cholesterol Transporters: Function and Regulation

2010

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Section: Mammary Glandsmentioning

confidence: 99%

Xenobiotic, Bile Acid, and Cholesterol Transporters: Function and Regulation

2010

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“…209 Mothers who breastfeed infants with known or suspected G6PD deficiency should not ingest fava beans or medications such as nitrofurantoin, primaquine phosphate, or phenazopyridine hydrochloride, which are known to induce hemolysis in deficient individuals. 210,211 …”

Section: Additional Recommendations For High-risk Infantsmentioning

confidence: 99%

Breastfeeding and the Use of Human Milk

2005

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ABSTRACT. Considerable advances have occurred in recent years in the scientific knowledge of the benefits of breastfeeding, the mechanisms underlying these benefits, and in the clinical management of breastfeeding. This policy statement on breastfeeding replaces the 1997 policy statement of the American Academy of Pediatrics and reflects this newer knowledge and the supporting publications. The benefits of breastfeeding for the infant, the mother, and the community are summarized, and recommendations to guide the pediatrician and other health care professionals in assisting mothers in the initiation and maintenance of breastfeeding for healthy term infants and high-risk infants are presented. The policy statement delineates various ways in which pediatricians can promote, protect, and support breastfeeding not only in their individual practices but also in the hospital, medical school, community, and nation. Pediatrics 2005;115:496-506; breast, breastfeeding, breast milk, human milk, lactation.ABBREVIATIONS. AAP, American Academy of Pediatrics; WIC, Supplemental Nutrition Program for Women, Infants, and Children; CMV, cytomegalovirus; G6PD, glucose-6-phosphate dehydrogenase. INTRODUCTIONE xtensive research using improved epidemiologic methods and modern laboratory techniques documents diverse and compelling advantages for infants, mothers, families, and society from breastfeeding and use of human milk for infant feeding. 1 These advantages include health, nutritional, immunologic, developmental, psychologic, social, economic, and environmental benefits. In 1997, the American Academy of Pediatrics (AAP) published the policy statement Breastfeeding and the Use of Human Milk. 2 Since then, significant advances in science and clinical medicine have occurred. This revision cites substantial new research on the importance of breastfeeding and sets forth principles to guide pediatricians and other health care professionals in assisting women and children in the initiation and maintenance of breastfeeding. The ways pediatricians can protect, promote, and support breastfeeding in their individual practices, hospitals, medical schools, and communities are delineated, and the central role of the pediatrician in coordinating breastfeeding management and providing a medical home for the child is emphasized. 3 THE NEED Child Health BenefitsHuman milk is species-specific, and all substitute feeding preparations differ markedly from it, making human milk uniquely superior for infant feeding. 12 Exclusive breastfeeding is the reference or normative model against which all alternative feeding methods must be measured with regard to growth, health, development, and all other short-and long-term outcomes. In addition, human milk-fed premature infants receive significant benefits with respect to host protection and improved developmental outcomes compared with formula-fed premature infants. [13][14][15][16][17][18][19][20][21][22] From studies in preterm and term infants, the following outcomes have been documented. Infectious Dise...

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“…ABCG2 is expressed on the apical surface of lactating mammary epithelial cells and facilitates the accumulation of substrate drugs in milk, including nitrofurantoin, cimetidine, topotecan, acyclovir, dietary carcinogens, ranitidine, and ciprofloxicin (Oo et al, 1995(Oo et al, , 2001McNamara et al, 1996;Gerk et al, 2001;Jonker et al, 2005;Merino et al, 2005Merino et al, , 2006van Herwaarden et al, 2007;Vlaming et al, 2009). Although diffusion plays a major role in drug appearance in milk, ABCG2 clearly contributes to the accumulation of its substrates in milk.…”

Section: Introductionmentioning

confidence: 99%