Active tissue adhesive activates mechanosensors and prevents muscle atrophy

Nam, Sungmin; Seo, Bo Ri; Najibi, Alexander J.; McNamara, Stephanie L.; Mooney, David J.

doi:10.1038/s41563-022-01396-x

Cited by 36 publications

(25 citation statements)

References 57 publications

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“…It offers local activity, avoids pleiotropic effects, and simplifies the regulatory approval process. [12] There have been many studies on the treatment of muscle atrophy by mechanical stimulation. [58][59][60] The use of hydrogels for the treatment of muscle atrophy has also been studied in recent years.…”

Section: Discussionmentioning

confidence: 99%

“…[9][10][11] The purpose of exercise or electrical stimulation is to actively or passively stretch the muscle fibers, stimulate the muscle cells to express proteins related to muscle growth in response to changes in external force, and facilitate the recovery of atrophied muscles. [12,13] Studies have shown that the muscles can sense external stimuli and react accordingly by exchanging tensional stress through close association and cooperation with fascial structures, which is described as myofascial force transmission. [14,15] Therefore, the fascia plays an important role in the treatment of muscle atrophy.…”

Section: Introductionmentioning

confidence: 99%

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Interstitial Injection of Hydrogels with High‐Mechanical Conductivity Relieves Muscle Atrophy Induced by Nerve Injury

Li,

Zhu,

Zhang

et al. 2023

Adv Healthcare Materials

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Injectable hydrogels have been extensively used in tissue engineering where high mechanical properties are key for their functionality at sites of high physiological stress. In this study, an injectable, conductive hydrogel is developed exhibiting remarkable mechanical strength that can withstand a pressure of 500 kPa (85% deformation rate) and display good fatigue resistance, electrical conductivity, and tissue adhesion. A stable covalent cross‐linked network with a slip‐ring structure by threading amino β‐cyclodextrin is formed onto the chain of a four‐armed (polyethylene glycol) amino group, and then reacted with the four‐armed (polyethylene glycol) maleimide under physiological conditions. The addition of silver nanowires enhances the hydrogel's electrical conductivity, enabling it to act as a good conductor in vivo. The hydrogel is injected into the fascial space, and the results show that the weight and muscle tone of the atrophied gastrocnemius muscle improve, subsequently alleviating muscle atrophy. Overall, this study provides a simple method for the preparation of a conductive hydrogel with high mechanical properties. In addition, the interstitial injection provides a strategy for the use of hydrogels in vivo.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Interstitial Injection of Hydrogels with High‐Mechanical Conductivity Relieves Muscle Atrophy Induced by Nerve Injury

Li,

Zhu,

Zhang

et al. 2023

Adv Healthcare Materials

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show abstract

“…158 Therefore, it is very difficult for bioelectronics to be in safe contact with the brain and spinal cord, which limits the treatment or regeneration of the nervous system. To address these issues of conventional electronics in the brain and spinal cord, several strategies have been suggested, such as direct drug release at the site of a tumor or lesion, 158 the use of biodegradable electronics to reduce surgical risk, 159 BCI 160 and electrical stimulation to muscles 161 Representatively, Neuralink (owned by Elon Musk) reported a brain-machine interface platform, which links the brain to a thin film chip via thousands of microchannels. 162 Likewise, microscale electronics and biocompatible multifunctional materials are being utilized more in research.…”

Section: Target-specific Key Parameters and Bioelectronic System Designmentioning

confidence: 99%

Wearable and implantable bioelectronics as eco‐friendly and patient‐friendly integrated nanoarchitectonics for next‐generation smart healthcare technology

Kim

Baek

Sluyter

et al. 2023

EcoMat

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Since the beginning of human history, the demand for effective healthcare systems for diagnosis and treatment of health problems has grown steadily. However, traditional centralized healthcare requires hospital visits, making in‐time and long‐term healthcare challenging. Bioelectronics has shown potential in patient‐friendly healthcare owing to the rapid advances in diverse fields of biology and electronics. In particular, wearable and implantable bioelectronics have emerged as an alternative or adjunct to conventional healthcare. To develop into next‐generation healthcare systems, however, custom designs for biological targets with a deepened understanding of the intrinsic features of the target are essential. In addition, bioelectronic systems must be designed eco‐friendly for sustainable healthcare. In this review, bioelectronics as eco‐friendly and patient‐friendly integrated nanoarchitectonics as next‐generation smart healthcare technology are described. For an in‐depth understanding of biological targets and guidelines for target‐tailored design, we discuss target‐specific considerations and relevant key parameters of bioelectronic systems with the representative examples.

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“…In response, various types of biomaterials are being developed that are engineered to provide desired mechanical stiffness or viscoelasticity necessary to provide enhanced functionality, and promising results have been obtained in preclinical models. For example, active biomaterials that can mechanically stimulate mechanosensory pathways in cells within living tissues have been developed and used to prevent muscle atrophy [ 76 ].…”

Section: Mechanobiology and Mechanotherapeuticsmentioning

confidence: 99%

From tensegrity to human organs-on-chips: implications for mechanobiology and mechanotherapeutics

Ingber

2023

Biochemical Journal

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The field of mechanobiology, which focuses on the key role that physical forces play in control of biological systems, has grown enormously over the past few decades. Here, I provide a brief personal perspective on the development of the tensegrity theory that contributed to the emergence of the mechanobiology field, the key role that crossing disciplines has played in its development, and how it has matured over time. I also describe how pursuing questions relating to mechanochemical transduction and mechanoregulation can lead to the creation of novel technologies and open paths for development of new therapeutic strategies for a broad range of diseases and disorders.

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Active tissue adhesive activates mechanosensors and prevents muscle atrophy

Cited by 36 publications

References 57 publications

Interstitial Injection of Hydrogels with High‐Mechanical Conductivity Relieves Muscle Atrophy Induced by Nerve Injury

Interstitial Injection of Hydrogels with High‐Mechanical Conductivity Relieves Muscle Atrophy Induced by Nerve Injury

Wearable and implantable bioelectronics as eco‐friendly and patient‐friendly integrated nanoarchitectonics for next‐generation smart healthcare technology

From tensegrity to human organs-on-chips: implications for mechanobiology and mechanotherapeutics

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