Active surveillance protocol in prostate cancer in Portugal

Gaspar, Sandro; Fernandes, M.; Castro, Ángel de; Oliveira, T.; Dias, Josiane Mourão; Reis, Jorge dos

doi:10.1016/j.acuroe.2022.01.002

Cited by 3 publications

(1 citation statement)

References 30 publications

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“…The primary methods for early PCa detection currently involve prostate-specific antigen (PSA) testing and targeted biopsies, which have significantly increased early diagnosis rates and reduced PCa mortality. However, concerns are rising regarding overdiagnosis and overtreatment [2], as numerous cases of PCa involve slow-growing tumors with a low likelihood of causing symptoms or mortality [3]. In clinically detected organ-confined low-risk PCa, radical prostatectomy has been associated with reduced mortality but at the expense of causing greater harm.…”

Section: Introductionmentioning

confidence: 99%

Multiparametric magnetic resonance imaging in the active surveillance of prostate cancer: protocol, risk stratification, and surveillance

2024

JOMH

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Active surveillance serves as a vital management strategy for patients diagnosed with low-risk, organ-confined prostate cancer and is aimed at reducing overtreatment, cost minimization and enhancing patients' quality of life. However, the comprehensive implementation of active surveillance faces various challenges necessitating improvement, such as refining screening criteria, optimizing surveillance procedures, and establishing clear guidelines for active intervention. Multiparametric magnetic resonance imaging (mp-MRI) has assumed an increasingly pivotal role in the context of active surveillance. It provides essential supplementary insights into the identification and characteristics of prostate cancer. mp-MRI improves the precision of risk stratification, thus enhancing patient selection and compliance. Furthermore, it facilitates continuous disease monitoring, thereby reducing the probability of missed treatment opportunities during follow-up. This review, characterized by its meticulous analysis, aims to comprehensively examine the utilization and advancements of mp-MRI in the active surveillance of prostate cancer.

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Section: Introductionmentioning

confidence: 99%

Multiparametric magnetic resonance imaging in the active surveillance of prostate cancer: protocol, risk stratification, and surveillance

2024

JOMH

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Multimorbidity patterns among patients hospitalized with prostate cancer in Portugal: a cluster analysis approach

Carvalho,

Souza,

Botelho

et al. 2024

Preprint

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Multimorbidity is a common condition among cancer patients, resulting in increased complexity of care and risk of negative outcomes. This study aims to use clustering analysis to identify and characterize multimorbidity patterns among hospitalized prostate cancer patients in Portugal. This is a retrospective observational study using inpatient data from the Portuguese National Hospital Morbidity Database. Data on hospital admissions with a diagnosis of prostate cancer occurring in all public hospitals in mainland Portugal during 2011–2017 were considered. Partitioning clustering algorithms, namely K-modes, PAM (Partitioning Around Medoids), and hierarchical clustering, were used to identify multimorbidity clusters. Results obtained from the different clustering approaches were compared and assessed in terms of clinical relevance. A total of 10394 inpatient episodes were analyzed, with 6091 (58%) reporting multimorbidity. Similar clusters were obtained through the different partitioning approaches, with PAM presenting a higher stability and the best quality results in terms of average silhouette. The analysis of the 6 clusters obtained with PAM reveals groups with a pattern of hypertension co-occurring with diabetes, obesity, and arrhythmia, in addition to cancer itself. In this study, the validity of cluster analysis as an exploratory method for identifying clusters of multimorbid conditions among prostate cancer patients in Portugal was demonstrated, identifying relevant patterns of disease co-occurrence, with potential impact on treatment decisions and outcomes. The identified clusters revealed conditions that typically co-occur with prostate of cancer and that can be controlled throughout all phases of cancer survivorship by means of healthier behaviors aligned with integrated and coordinated care.

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Anxiety and Depression in Patients with Prostate Cancer, at Cancer Diagnosis and after a One-Year Follow-Up

Duarte

Araújo

Lopes

et al. 2022

IJERPH

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Prostate cancer (PCa) is the most prevalent among men, and psychological symptoms may affect many patients. This study aims to describe the prevalence of probable anxiety and depression before PCa treatments and after one year and to identify sociodemographic and clinical factors associated with these outcomes. Between February 2018 and March 2020, 292 patients recently diagnosed with PCa were recruited at the Instituto Português de Oncologia—Porto. The Hospital Anxiety and Depression Scale (HADS) was used to define probable anxiety and depression (cutoff = 11). The prevalence of probable anxiety remained stable from baseline to one year (7.8% vs. 8.5%, p = 0.866) while there was an increase in probable depression (3.1% vs. 6.8%, p = 0.012). After one year, probable depression persisted in 55.6% of patients with probable depression at baseline and 47.8% of those with probable anxiety at the first assessment had normal anxiety scores. At baseline, anxiety was more frequent among dwellers in rural areas (adjusted odds ratio—aOR, 95%CI: 2.80, 0.91–8.58) and less frequent in patients with body mass index 25–29.9 kg/m2 (aOR, 95%CI: 0.33, 0.12–0.91) compared to 18.5–24.9 Kg/m2, while those living alone had higher odds of depression (aOR, 95%CI: 6.35, 1.43–28.30). The frequency of anxiety and depression fluctuated during the course of treatment. Monitoring these symptoms would identify the most affected patients, contributing for a better use of mental health services.

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Active surveillance protocol in prostate cancer in Portugal

Cited by 3 publications

References 30 publications

Multiparametric magnetic resonance imaging in the active surveillance of prostate cancer: protocol, risk stratification, and surveillance

Multiparametric magnetic resonance imaging in the active surveillance of prostate cancer: protocol, risk stratification, and surveillance

Multimorbidity patterns among patients hospitalized with prostate cancer in Portugal: a cluster analysis approach

Anxiety and Depression in Patients with Prostate Cancer, at Cancer Diagnosis and after a One-Year Follow-Up

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