Active surveillance of bat rabies in France: A 5-year study (2004–2009)

Picard-Meyer, Evelyne; Dubourg-Savage, Marie-Jo; Arthur, Laurent; Barataud, Michel; Bécu, David; Bracco, Sandrine; Borel, Christophe; Larcher, Gérald; Meme-Lafond, Benjamin; Moinet, Marie; Robardet, Emmanuelle; Wasniewski, Marine; Cliquet, Florence

doi:10.1016/j.vetmic.2011.03.034

Cited by 40 publications

(54 citation statements)

References 28 publications

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“…French passive bat rabies surveillance in particular should be improved with regard to targeted bat species such as serotines, Natterer's bats and Daubenton's bats. These results, complemented by active surveillance data [47], will help clarify the dynamics of EBLV-1 transmission and improve understanding of the cross-species infection process. To date, two cases of natural transmission of EBLV-1 to domestic cats have been reported in France [49], demonstrating that the two subtypes, a and b, of EBLV-1 are able to cross the species barrier.…”

Section: Discussionmentioning

confidence: 92%

“…We previously reported the presence of EBLV-1 neutralising antibodies in six indigenous bat species throughout France, mainly in E. serotinus and M. myotis , suggesting previous infection with the EBLV-1 rabies virus [47]. However, no EBLV-1 RNA was detected in the RT-PCRs performed on oropharyngeal swabs collected from these six apparently healthy bats [47]. Similarly, a high percentage of seropositive bat species (65%) was recently found in Spain, suggesting that most species of bats are exposed to EBLV-1 [32].…”

Section: Discussionmentioning

confidence: 93%

“…It is clear that bats can experience either a lethal or non-lethal rabies virus infection, with in the latter case the development of specific neutralising antibodies [46]. We previously reported the presence of EBLV-1 neutralising antibodies in six indigenous bat species throughout France, mainly in E. serotinus and M. myotis , suggesting previous infection with the EBLV-1 rabies virus [47]. However, no EBLV-1 RNA was detected in the RT-PCRs performed on oropharyngeal swabs collected from these six apparently healthy bats [47].…”

Section: Discussionmentioning

confidence: 99%

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Bat Rabies in France: A 24-Year Retrospective Epidemiological Study

et al. 2014

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Since bat rabies surveillance was first implemented in France in 1989, 48 autochthonous rabies cases without human contamination have been reported using routine diagnosis methods. In this retrospective study, data on bats submitted for rabies testing were analysed in order to better understand the epidemiology of EBLV-1 in bats in France and to investigate some epidemiological trends. Of the 3176 bats submitted for rabies diagnosis from 1989 to 2013, 1.96% (48/2447 analysed) were diagnosed positive. Among the twelve recognised virus species within the Lyssavirus genus, two species were isolated in France. 47 positive bats were morphologically identified as Eptesicus serotinus and were shown to be infected by both the EBLV-1a and the EBLV-1b lineages. Isolation of BBLV in Myotis nattereri was reported once in the north-east of France in 2012. The phylogenetic characterisation of all 47 French EBLV-1 isolates sampled between 1989 and 2013 and the French BBLV sample against 21 referenced partial nucleoprotein sequences confirmed the low genetic diversity of EBLV-1 despite its extensive geographical range. Statistical analysis performed on the serotine bat data collected from 1989 to 2013 showed seasonal variation of rabies occurrence with a significantly higher proportion of positive samples detected during the autumn compared to the spring and the summer period (34% of positive bats detected in autumn, 15% in summer, 13% in spring and 12% in winter). In this study, we have provided the details of the geographical distribution of EBLV-1a in the south-west of France and the north-south division of EBLV-1b with its subdivisions into three phylogenetic groups: group B1 in the north-west, group B2 in the centre and group B3 in the north-east of France.

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Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 99%

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Bat Rabies in France: A 24-Year Retrospective Epidemiological Study

et al. 2014

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“…These conclusions may differ from that found by other authors in other countries where the lack of findings suggests the absence of an active rabies infection (Mani et al, 2017). Thereby, active bat surveillance for RABV in other countries has also reported a very low prevalence of viral antigen or nucleic acid in healthy bat populations (Picard-Meyer et al, 2011;Nokireki et al, 2013;Ellison et, 2014;Schatz et al, 2014) The lack of a sampling with longer duration and/ or with greater expansion of the search area could be a limiting factor of this study for the lack of positive results. Also as a limitation of the study, a larger number of specimens could have been sent for diagnosis, which would increase the chance of detection.…”

Section: Carollia Perspicillata D Rotundus and A Lituratusmentioning

confidence: 94%

Serological Survey of Rabies Virus Infection among Bats in Brazil

Horta

Oliveira

Miranda

et al. 2018

VR&R

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Rabies is a disease caused by a virus belonging to the family Rhabdoviridae, genus Lyssavirus (RABV), and is characterized as a progressive and acute encephalitis that presents high lethality. Between 2002 and 2012, 2149 wild animals were found positive for RABV in Brazil where 79% were associated with the aerial cycle of the disease. As part of the active surveillance of rabies in Brazil, the objective of this study was to investigate the presence of RABV infection in bats captured in the metropolitan region of Rio de Janeiro city. Forty-four bats were tested for RABV at Institute Jorge Vaitsman (IJV), reference laboratory for rabies in Rio de Janeiro State. Of the individuals captured and sent for the diagnosis of rabies, a total of 15 were identified as being hematophagous, all of them belonging to the species Desmodus rotundus. Twenty-four individuals were considered as frugivorous, four as insectivores and one individual (Lonchophylla peracchii) identified as having a pollen/ nectar feeding habit. All specimen sent to RABV diagnosis presented negative results. Considering the active surveillance for RABV in Brazil, studies of fauna survey with serological characterization are important in the strengthening of epidemiological surveillance and protection of human life.

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“…For instance, multi-site cross-sectional data could be integrated with single-site longitudinal data (e.g., Picard-Meyer et al 2011, Robardet et al 2017 to overcome the need of a priori knowledge on the host kinetics of the immune response, which is likely conserved within a species sampled across sites. The cross-sectional estimator can nonetheless be accurate for hosts with short lifespan and/or short antibody level persistence or when informed with reliable a priori knowledge on these parameters.…”

Section: Discussionmentioning

confidence: 99%

Next‐generation serology: integrating cross‐sectional and capture–recapture approaches to infer disease dynamics

Gamble¹,

Garnier

Chambert

et al. 2020

Ecology

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Two approaches have been classically used in disease ecology to estimate epidemiological parameters from field studies: cross-sectional sampling from unmarked individuals and longitudinal capture-recapture setups, which generally involve more limited numbers of marked individuals due to cost and logistical constraints. Although the benefits of longitudinal setups are increasingly acknowledged in the disease ecology community, cross-sectional data remain largely overrepresented in the literature, probably because of the inherent costs of longitudinal surveys. In this context, we used simulated data to compare the performances of cross-sectional and longitudinal designs to estimate the force of infection (i.e., the rate at which susceptible individuals become infected). Then, inspired from recent method developments in quantitative ecology, we explore the benefits of integrating both cross-sectional (seroprevalences) and longitudinal (individuals histories) data sets. In doing so, we investigate the effects of host species life history, antibody persistence, and degree of a priori knowledge and uncertainty on demographic and epidemiological parameters, as those are expected to affect in different ways the level of inference possible from the data. Our results highlight how those elements are important to consider in determining optimal sampling designs. In the case of long-lived species exposed to infectious agents resulting in persistent antibody responses, integrated designs are especially valuable as they benefit from the performances of longitudinal designs even with relatively small longitudinal sample sizes. As an illustration, we apply this approach to a combination of empirical and simulated data inspired from a case of bats exposed to a rabies virus. Overall, this work highlights that serology field studies could greatly benefit from the opportunity of integrating cross-sectional and longitudinal designs.

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Active surveillance of bat rabies in France: A 5-year study (2004–2009)

Cited by 40 publications

References 28 publications

Bat Rabies in France: A 24-Year Retrospective Epidemiological Study

Bat Rabies in France: A 24-Year Retrospective Epidemiological Study

Serological Survey of Rabies Virus Infection among Bats in Brazil

Next‐generation serology: integrating cross‐sectional and capture–recapture approaches to infer disease dynamics

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