2007
DOI: 10.1111/j.1365-2796.2006.01746.x
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Active sugar transport in health and disease

Abstract: Secondary active glucose transport occurs by at least four members of the SLC5 gene family. This review considers the structure and function of two premier members, SGLT1 and SGLT2, and their role in intestinal glucose absorption and renal glucose reabsorption. Genetics disorders of SGLTs include GlucoseGalactose Malabsorption, and Familial Renal Glucosuria. SGLT1 plays a central role in Oral Rehydration Therapy used so effectively to treat secretory diarrhoea such as cholera. Increasing attention is being foc… Show more

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Cited by 571 publications
(517 citation statements)
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“…There is growing evidence that targeting SGLT-mediated renal glucose transport using phlorizin-like inhibitors may be useful in treating diabetes [32]. Two sodium-dependent transporters are produced in the kidney: the bulk of the filtered glucose is reabsorbed in the S1 segment by the lowaffinity, high-capacity transporter, SGLT2; whereas the high-affinity, low-capacity transporter, SGLT1, scavenges the remaining glucose more distally (reviewed in [17]).…”
Section: Discussionmentioning
confidence: 99%
“…There is growing evidence that targeting SGLT-mediated renal glucose transport using phlorizin-like inhibitors may be useful in treating diabetes [32]. Two sodium-dependent transporters are produced in the kidney: the bulk of the filtered glucose is reabsorbed in the S1 segment by the lowaffinity, high-capacity transporter, SGLT2; whereas the high-affinity, low-capacity transporter, SGLT1, scavenges the remaining glucose more distally (reviewed in [17]).…”
Section: Discussionmentioning
confidence: 99%
“…Under normal conditions,~180 g of glucose are filtered by the kidney glomerulus per day, and virtually the entire amount is reabsorbed in the proximal tubule [6]. The absorption of glucose in the small intestine and the reabsorption in the kidney occurs passively by glucose transporters (GLUTs) and actively by sodium-glucose cotransporters (SGLTs) [7].…”
mentioning
confidence: 99%
“…The SGLT2 and GLUT2 are expressed predominantly in cells of the proximal tubule of the kidney on the S1 segment, where the majority of glucose reabsorption (~90%) is accomplished [7]. Meanwhile,~10% is reabsorbed in the S3 regimen, where SGLT1 and GLUT1 are located [7].…”
mentioning
confidence: 99%
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