(Nakanarusawa-cho 4-12-1, Hitachi, Ibaraki, 316-8511, Japan)The identification and control of large-scale structures are considered to be difficult due to structural complicacy and system uncertainties. In this paper, based on the concept of localized control and neural networks, a computational algorithm for earthquake response control of large-scale structures is proposed. In this algorithm, the control-structure interaction (CSI) and actuator dynamics are considered. Moreover, electro-hydraulic actuators as practical applications are designed to simulate the proposed control algorithm. Results from the numerical simulations have shown great promise for the control of large-scale civil engineering structures with localized control using neural networks.