This paper presents a deep analysis of different feed-forward (FF) techniques combined with two different proportional-integral-derivative (PID) control to guide a real piezoelectric actuator (PEA). These devices are well known for a non-linear effect called “hysteresis” which generates an undesirable performance during the device operation. First, the PEA was analysed under real experiments to determine the response with different frequencies and voltages. Secondly, a voltage and frequency inputs were chosen and a study of different control approaches was performed using a conventional PID in close-loop, adding a linear compensation and a FF with the same PID and an artificial neural network (ANN). Finally, the best result was contrasted with an adaptive PID which used a single neuron (SNPID) combined with Hebbs rule to update its parameters. Results were analysed in terms of guidance, error and control signal whereas the performance was evaluated with the integral of the absolute error (IAE). Experiments showed that the FF-ANN compensation combined with an SNPID was the most efficient.