1988
DOI: 10.1183/09031936.93.01090839
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Active sensitization of guinea-pig airways in vivo enhances in vivo and in vitro responsiveness

Abstract: A plethysmographic method was employed to assess the airway resistance of conscious, free-breathing guinea-pigs. Using this method animals sensitized by inhalation of ovalbumin and appropriate controls were assessed for their responsiveness to histamine and methacholine in vivo. The cough frequency on exposure to citric acid mist in the two groups was also assessed. Tracheal spirals from these animals were subsequently tested for their responsiveness to histamine, methacholine and prostaglandin D2 in vitro. Se… Show more

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Cited by 30 publications
(2 citation statements)
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“…and histamine. These results confirm previous findings from this laboratory [8,9,15] and are in agreement with those from other research groups [7,[10][11][12]19]. Differences with other reports [20][21][22] may be related to methodological differences, mainly in the immunization procedure, and have been discussed previously [9,15].…”
Section: Discussionsupporting
confidence: 93%
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“…and histamine. These results confirm previous findings from this laboratory [8,9,15] and are in agreement with those from other research groups [7,[10][11][12]19]. Differences with other reports [20][21][22] may be related to methodological differences, mainly in the immunization procedure, and have been discussed previously [9,15].…”
Section: Discussionsupporting
confidence: 93%
“…In vitro studies with tracheal and lung parenchyma! strips obtained from actively sensitized guinea-pigs demonstrate a nonspecific hyperresponsiveness to autonomic drugs, endogenous autacoids and other exogenous spasmogens [7][8][9][10][11][12]. This enhanced responsiveness has characteristics resembling those of post-junctional supersen itivity (9 13].…”
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confidence: 99%